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Advanced Search Results For "LIBRARIES"

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 "LIBRARIES"
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On-DNA Synthesis of Functionalized 4 H -Pyran Scaffolds for Focused DNA-Encoded Chemical Libraries.

Publication Type:Academic Journal

Source(s):Organic letters [Org Lett] 2022 Sep 16; Vol. 24 (36), pp. 6664-6669. Date of Electronic Publication: 2022 Sep 02.

Abstract:The functionalized 4 H -pyran scaffold has aroused synthetic attention because it is widely found in many interesting pharmacologically relevant compounds. We here disclose its incorporation into DNA-encoded chemical libraries, combining this scaffold ...

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On-DNA Hydroalkylation to Introduce Diverse Bicyclo[1.1.1]pentanes and Abundant Alkyls via Halogen Atom Transfer.

Publication Type:Academic Journal

Source(s):Journal of the American Chemical Society [J Am Chem Soc] 2022 Jul 13; Vol. 144 (27), pp. 12184-12191. Date of Electronic Publication: 2022 Jun 27.

Abstract:DNA-encoded libraries have proven their tremendous value in the identification of new lead compounds for drug discovery. To access libraries in new chemical space, many methods have emerged to transpose traditional mol-scale reactivity to nmol-scale, o...

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Insights and opinions of readers of the Journal of the Medical Library Association .

Publication Type:Editorial & Opinion

Source(s):Journal of the Medical Library Association : JMLA [J Med Libr Assoc] 2022 Apr 01; Vol. 110 (2), pp. 156-158.

Abstract:The Journal of the Medical Library Association (JMLA) conducted a readership survey in 2020 to gain a deeper understanding of our readers, their reading habits, and their satisfaction with JMLA 's content, website functionality, and overall quality. A ...

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N-Alkyl Linkers for DNA-Encoded Chemical Libraries.

Publication Type:Academic Journal

Source(s):Chemistry, an Asian journal [Chem Asian J] 2022 Apr 01; Vol. 17 (7), pp. e202200016. Date of Electronic Publication: 2022 Mar 07.

Abstract:A series of novel N-alkyl linkers that connect small-molecule library members with their encoding DNA oligonucleotides has been developed. In comparison with the standard amide linker (usually constructed with oligo-AOP-NH 2 ), the N-alkyl linker is no...

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Supporting the Spectrum Scholarship Program: perspectives from the Northern California and Nevada Medical Library Group.

Publication Type:Academic Journal

Source(s):Journal of the Medical Library Association : JMLA [J Med Libr Assoc] 2022 Apr 01; Vol. 110 (2), pp. 243-246.

Abstract:The immediate past presidents and current president of the Northern California and Nevada Medical Library Group write to raise awareness of the American Library Association Spectrum Scholarship Program, share their approach to supporting Scholars in th...

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Visible Light-Promoted Divergent Benzoheterocyclization from Aldehydes for DNA-Encoded Chemical Libraries.

Publication Type:Academic Journal

Source(s):Organic letters [Org Lett] 2022 May 06; Vol. 24 (17), pp. 3291-3296. Date of Electronic Publication: 2022 Apr 25.

Abstract:Benzoheterocyclics have been widely adopted as drug-like core scaffolds that can be incorporated into DNA-encoded chemical library technology for high-throughput hit discovery. Here, we present a visible light-promoted divergent synthesis of on-DNA ben...

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Health Libraries Group at 75.

Publication Type:Editorial & Opinion

Source(s):Health information and libraries journal [Health Info Libr J] 2022 Mar; Vol. 39 (1), pp. 1-5.

Abstract:Celebrating its 75th year in 2022, Lynsey Hawker and Imrana Ghumra, Co-Chairs of the Health Libraries Group (HLG) look back on its origins, celebrate key activities and achievements. From its humble beginnings as the Medical Section of the UK Library A...

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Analysis of DNA-Encoded Library Screening Data: Selection of Molecules for Synthesis.

Publication Type:Academic Journal

Source(s):Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2541, pp. 195-205.

Abstract:DNA-encoded library (DEL) screens are used to discover novel chemical matter capable of modulating the activity of pharmaceutically interesting protein targets. DEL selections are accomplished by immobilizing a target protein on a resin and capturing l...

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Initiating DNA-Encoded Library Synthesis with a Hexathymidine DNA Oligonucleotide.

Publication Type:Academic Journal

Source(s):Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2541, pp. 89-104.

Abstract:Libraries of DNA-encoded compounds (DELs) are a validated screening technology for drug discovery. Here we describe a library synthesis strategy that starts with a solid phase-bound, chemically very stable hexathymidine DNA sequence "hexT." Different h...

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Selection Method of DNA-Encoded Chemical Library for Irreversible Covalent Binders.

Publication Type:Academic Journal

Source(s):Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2541, pp. 165-172.

Abstract:Compounds acting through irreversible covalent interactions with therapeutic targets represent an important mechanism of drug action. Here I describe a selection method for DNA-encoded libraries to discover irreversible covalent binders to target prote...

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