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CD40-CD40 ligand interaction between periodontal ligament cells and cementoblasts enhances periodontal tissue remodeling in response to mechanical stress.
Publication Type: Academic Journal
Source(s): Journal of periodontal research [J Periodontal Res] 2023 Dec; Vol. 58 (6), pp. 1261-1271. Date of Electronic Publication: 2023 Sep 18.
Abstract: Objective: We analyzed the localization and expression of Cluster of differentiation 40 ligand (CD40L) in murine periodontal tissue applied with the orthodontic force to determine the CD40L-expressing cells under mechanical stress. Furthermore, we inve...
Design and One-Pot Ultrasound Synthesis of Inorganic Base-Promoted Fluorescent Ligand-Gated Ion Channel Fused Arylpyrazole Sulfonamide Skeletons to Enhance Phloem Mobility and Insecticidal Activity as GABA and nACh Receptors Inhibitors.
Publication Type: Academic Journal
Source(s): Journal of agricultural and food chemistry [J Agric Food Chem] 2023 Nov 01; Vol. 71 (43), pp. 16331-16351. Date of Electronic Publication: 2023 Oct 23.
Abstract: Ligand-gated ion channels are essential in living organisms, and sulfonamides have antibacterial effects and can be readily coordinated with metal ions with good biological activity. A series of fluorescent ligand-gated ion channel fused arylpyrazole s...
Potential role of soluble CD40 receptor in chronic inflammatory diseases.
Publication Type: Academic Journal
Source(s): Biochemical pharmacology [Biochem Pharmacol] 2023 Nov; Vol. 217, pp. 115858. Date of Electronic Publication: 2023 Oct 18.
Abstract: The CD40 receptor and its ligand CD154 are widely expressed in various immune-competent cells. Interaction of CD154 with CD40 is essential for B-cell growth, differentiation, and immunoglobulin class switching. Many other immune-competent cells involve...
The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8).
Publication Type: Academic Journal
Source(s): Autophagy [Autophagy] 2023 Oct; Vol. 19 (10), pp. 2733-2751. Date of Electronic Publication: 2023 Jul 07.
Abstract: Apoptosis is a tightly controlled cell death program executed by proteases, the so-called caspases. It plays an important role in tissue homeostasis and is often dysregulated in cancer. Here, we identified FYCO1, a protein that promotes microtubule plu...
Fast functional mapping of ligand-gated ion channels.
Publication Type: Academic Journal
Source(s): Communications biology [Commun Biol] 2023 Oct 02; Vol. 6 (1), pp. 1003. Date of Electronic Publication: 2023 Oct 02.
Abstract: Ligand-gated ion channels are formed by three to five subunits that control the opening of the pore in a cooperative fashion. We developed a microfluidic chip-based technique for studying ion currents and fluorescence signals in either excised membrane...
The Haemonchus contortus LGC-39 subunit is a novel subtype of an acetylcholine-gated chloride channel.
Publication Type: Academic Journal
Source(s): International journal for parasitology. Drugs and drug resistance [Int J Parasitol Drugs Drug Resist] 2023 Aug; Vol. 22, pp. 20-26. Date of Electronic Publication: 2023 Apr 06.
Abstract: The nematode genome exhibits a vast array of Cys-loop receptors that are activated by a diverse set of neurotransmitters and anthelmintic drugs such as ivermectin and levamisole. While many Cys-loop receptors have been functionally and pharmacologicall...
Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor.
Publication Type: Academic Journal
Source(s): ELife [Elife] 2023 Jul 03; Vol. 12. Date of Electronic Publication: 2023 Jul 03.
Abstract: Cys-loop receptors or pentameric ligand-gated ion channels are mediators of electrochemical signaling throughout the animal kingdom. Because of their critical function in neurotransmission and high potential as drug targets, Cys-loop receptors from hum...
Snoopligase-catalyzed molecular glue enables efficient generation of hyperoligomerized TRAIL variant with enhanced antitumor effect.
Publication Type: Academic Journal
Source(s): Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2023 Sep; Vol. 361, pp. 856-870. Date of Electronic Publication: 2023 Aug 29.
Abstract: Clinical application of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is predominantly limited by its inefficient apoptosis induction in tumor cells, which might be improved by using molecular superglue-mediated hyperoligomerization t...
Tubeimoside-1 Enhances TRAIL-Induced Apoptotic Cell Death through STAMBPL1-Mediated c-FLIP Downregulation.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jul 24; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 24.
Abstract: Tubeimoside-1 (TBMS-1), a traditional Chinese medicinal herb, is commonly used as an anti-cancer agent. In this study, we aimed to investigate its effect on the sensitization of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (T...
Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption.
Publication Type: Academic Journal
Source(s): Respiratory research [Respir Res] 2023 Jul 11; Vol. 24 (1), pp. 182. Date of Electronic Publication: 2023 Jul 11.
Abstract: Alveolar epithelial barrier is a potential therapeutic target for acute respiratory distress syndrome (ARDS). However, an effective intervention against alveolar epithelial barrier has not been developed. Here, based on single-cell RNA and mRNA sequenc...