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Advanced Search Results For "LONGEVITY"

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 "LONGEVITY"
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Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan.

Publication Type: Academic Journal

Source(s): Cell [Cell] 2023 Jan 05; Vol. 186 (1), pp. 63-79.e21.

Abstract: Metabolism is deeply intertwined with aging. Effects of metabolic interventions on aging have been explained with intracellular metabolism, growth control, and signaling. Studying chronological aging in yeast, we reveal a so far overlooked metabolic pr...

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Clinical Longevity of 106,462 Rechargeable and Primary Cell Spinal Cord Stimulators: Real World Study in the Medicare Population.

Publication Type: Academic Journal

Source(s): Neuromodulation : journal of the International Neuromodulation Society [Neuromodulation] 2023 Jan; Vol. 26 (1), pp. 131-138. Date of Electronic Publication: 2022 Jun 09.

Abstract: Introduction: Spinal cord stimulators (SCS) are available with either primary cell (PC) or rechargeable cell (RC) batteries. Although RC systems are proposed to have a battery longevity upward of nine years, in comparison with four years for PC systems...

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Why Is Longevity Still a Scientific Mystery? Sirtuins-Past, Present and Future.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Dec 31; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 31.

Abstract: The sirtuin system consists of seven highly conserved regulatory enzymes responsible for metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is associated with the potential impact on life extension. This artic...

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Isocitrate Dehydrogenase Alpha-1 Modulates Lifespan and Oxidative Stress Tolerance in Caenorhabditis elegans .

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Dec 29; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 29.

Abstract: Altered metabolism is a hallmark of aging. The tricarboxylic acid cycle (TCA cycle) is an essential metabolic pathway and plays an important role in lifespan regulation. Supplementation of α-ketoglutarate, a metabolite converted by isocitrate dehydroge...

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Single short reprogramming early in life increases healthspan.

Publication Type: Editorial & Opinion

Source(s): Aging [Aging (Albany NY)] 2022 Dec 26; Vol. 14 (24), pp. 9779-9781. Date of Electronic Publication: 2022 Dec 26.

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A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Dec 21; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 21.

Abstract: We performed a genome-wide association study (GWAS) of human extreme longevity (EL), defined as surviving past the 99th survival percentile, by aggregating data from four centenarian studies. The combined data included 2304 EL cases and 5879 controls. ...

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Autophagy and longevity: Evolutionary hints from hyper-longevous mammals.

Publication Type: Academic Journal

Source(s): Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Dec 20; Vol. 13, pp. 1085522. Date of Electronic Publication: 2022 Dec 20 (Print Publication: 2022).

Abstract: Autophagy is a fundamental multi-tasking adaptive cellular degradation and recycling strategy. Following its causal implication in age-related decline, autophagy is currently among the most broadly studied and challenged mechanisms within aging researc...

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Dietary restriction and ageing: Recent evolutionary perspectives.

Publication Type: Academic Journal

Source(s): Mechanisms of ageing and development [Mech Ageing Dev] 2022 Dec; Vol. 208, pp. 111741. Date of Electronic Publication: 2022 Sep 24.

Authors:

Abstract: Dietary restriction (DR) represents one of the most robust interventions for extending lifespan. It is not known how DR increases lifespan. The prevailing evolutionary hypothesis suggests the DR response redirects metabolic resources towards somatic ma...

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Optimizing Translational Research for Exceptional Health and Life Span: A Systematic Narrative of Studies to Identify Translatable Therapeutic Target(s) for Exceptional Health Span in Humans.

Publication Type: Academic Journal

Source(s): The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2022 Nov 21; Vol. 77 (11), pp. 2272-2280.

Abstract: Background: Exceptional longevity as manifested by the lower incidence and delayed onset of age-related disabilities/diseases that include cardiovascular disease, Alzheimer's disease, cancer is believed to be influenced by inherent protective molecular...

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dNAGLU Extends Life Span and Promotes Fitness and Stress Resistance in Drosophila .

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Nov 20; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 20.

Authors:

Abstract: To identify new factors that promote longevity and healthy aging, we studied Drosophila CG13397 , an ortholog of the human NAGLU gene, a lysosomal enzyme overexpressed in centenarians. We found that the overexpression of CG13397 ( dNAGLU ) ubiquitously...

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