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Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.
Publication Type: Academic Journal
Source(s): Molecular cell [Mol Cell] 2023 Aug 17; Vol. 83 (16), pp. 2872-2883.e7.
Abstract: SUV420H1 di- and tri-methylates histone H4 lysine 20 (H4K20me2/H4K20me3) and plays crucial roles in DNA replication, repair, and heterochromatin formation. It is dysregulated in several cancers. Many of these processes were linked to its catalytic acti...
Lysine N-methyltransferase SETD7 promotes bladder cancer progression and immune escape via STAT3/PD-L1 cascade.
Publication Type: Academic Journal
Source(s): International journal of biological sciences [Int J Biol Sci] 2023 Jul 16; Vol. 19 (12), pp. 3744-3761. Date of Electronic Publication: 2023 Jul 16 (Print Publication: 2023).
Abstract: Background: The immunotherapy sensitivity of patients with bladder cancer (BCa) remains low. As the role of protein methylation in tumorigenesis and development becomes clearer, the role of lysine N-methyltransferase SET domain containing 7 (SETD7) in ...
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Publication Type: Academic Journal
Source(s): Cell death and differentiation [Cell Death Differ] 2023 Sep; Vol. 30 (9), pp. 2135-2150. Date of Electronic Publication: 2023 Aug 21.
Abstract: Impaired transcription factor EB (TFEB) function and deficient autophagy activity have been shown to aggravate intervertebral disc (IVD) degeneration (IDD), yet the underlying mechanisms remain less clear. Protein posttranslational modifications (PTMs)...
Quantitative Acetylomics Reveals Substrates of Lysine Acetyltransferase GCN5 in Adult and Aging Drosophila .
Publication Type: Academic Journal
Source(s): Journal of proteome research [J Proteome Res] 2023 Sep 01; Vol. 22 (9), pp. 2909-2924. Date of Electronic Publication: 2023 Aug 06.
Abstract: Protein lysine acetylation is a dynamic post-translational modification (PTM) that regulates a wide spectrum of cellular events including aging. General control nonderepressible 5 (GCN5) is a highly conserved lysine acetyltransferase (KAT). However, th...
Lysine Acetyltransferases (KATs) in Disguise: Diseases Implications.
Publication Type: Academic Journal
Source(s): Journal of biochemistry [J Biochem] 2023 May 29; Vol. 173 (6), pp. 417-433.
Abstract: Acetylation is one of the key post-translational protein modifications catalysed by the protein lysine acetyltransferases (KATs). KATs catalyse the transfer of acetyl groups to the epsilon-amino groups of lysine residues in histones and non-histone pro...
Regulation of EBNA1 protein stability and DNA replication activity by PLOD1 lysine hydroxylase.
Publication Type: Academic Journal
Source(s): PLoS pathogens [PLoS Pathog] 2023 Jun 01; Vol. 19 (6), pp. e1010478. Date of Electronic Publication: 2023 Jun 01 (Print Publication: 2023).
Abstract: Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that is causally associated with various malignancies and autoimmune disease. Epstein-Barr Nuclear Antigen 1 (EBNA1) is the viral-encoded DNA binding protein required for viral episome mainte...
Structure-Based Design and Characterization of the Highly Potent and Selective Covalent Inhibitors Targeting the Lysine Methyltransferases G9a/GLP.
Publication Type: Academic Journal
Source(s): Journal of medicinal chemistry [J Med Chem] 2023 Jun 22; Vol. 66 (12), pp. 8086-8102. Date of Electronic Publication: 2023 Jun 02.
Abstract: Protein lysine methyltransferases G9a and GLP, which catalyze mono- and di-methylation of histone H3K9 and nonhistone proteins, play important roles in diverse cellular processes. Overexpression or dysregulation of G9a and GLP has been identified in va...
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Publication Type: Academic Journal
Source(s): Science advances [Sci Adv] 2023 Jun 16; Vol. 9 (24), pp. eade6624. Date of Electronic Publication: 2023 Jun 14.
Abstract: DNA damage repair (DDR) is a double-edged sword with different roles in cancer susceptibility and drug resistance. Recent studies suggest that DDR inhibitors affect immune surveillance. However, this phenomenon is poorly understood. We report that meth...
SET7 methylates the deubiquitinase OTUB1 at Lys 122 to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis.
Publication Type: Academic Journal
Source(s): The Journal of biological chemistry [J Biol Chem] 2023 Apr; Vol. 299 (4), pp. 103054. Date of Electronic Publication: 2023 Feb 22.
Abstract: The deubiquitinating enzyme OTUB1 possesses canonical deubiquitinase (DUB) activity and noncanonical, catalytic-independent activity, which has been identified as an essential regulator of diverse physiological processes. Posttranslational modification...
Protein Lysine Methyltransferases Inhibitors.
Publication Type: Academic Journal
Source(s): Current medicinal chemistry [Curr Med Chem] 2023; Vol. 30 (27), pp. 3060-3089.
Abstract: Protein lysine methylation is a significant protein post-translational modification (PTMs) and has a key function in epigenetic regulation. Protein lysine methyltransferase (PKMTs) mainly catalyzes the lysine methylation of various core histones and a ...