Advanced Search Results For "Lysine analogs & derivatives"
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Ketoprofen lysine salt has a better gastrointestinal and renal tolerability than ketoprofen acid: A comparative tolerability study in the Beagle dog.
Publication Type: Academic Journal
Source(s): Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Sep; Vol. 153, pp. 113336. Date of Electronic Publication: 2022 Jun 27.
Abstract: Due to the widespread use of non-steroidal anti-inflammatory drugs (NSAIDs), the incidence of NSAID-associated adverse events has increased exponentially over the past decades. Ketoprofen (ketoprofen acid, KA) is a widely used NSAID and, like with othe...
Comparison of tissue distribution of free and protein bound Nɛ-carboxymethyllysine after long-term oral administration to mice.
Publication Type: Academic Journal
Source(s): Food research international (Ottawa, Ont.) [Food Res Int] 2022 Nov; Vol. 161, pp. 111787. Date of Electronic Publication: 2022 Aug 24.
Abstract: Nɛ-Carboxymethyl-lysine (CML) is a primary advanced glycation end product that exists in the body and food as free and bound forms with different bioavailability and physiological effects. To compare the uptake, tissue distribution, and fecal excretion...
Ancestral archaea expanded the genetic code with pyrrolysine.
Publication Type: Academic Journal
Source(s): The Journal of biological chemistry [J Biol Chem] 2022 Nov; Vol. 298 (11), pp. 102521. Date of Electronic Publication: 2022 Sep 22.
Abstract: The pyrrolysyl-tRNA synthetase (PylRS) facilitates the cotranslational installation of the 22nd amino acid pyrrolysine. Owing to its tolerance for diverse amino acid substrates, and its orthogonality in multiple organisms, PylRS has emerged as a major ...
N6-methyladenosine modification in trophoblasts promotes circSETD2 expression, inhibits miR-181a-5p, and elevates MCL1 transcription to reduce apoptosis of trophoblasts.
Publication Type: Academic Journal
Source(s): Environmental toxicology [Environ Toxicol] 2023 Feb; Vol. 38 (2), pp. 422-435. Date of Electronic Publication: 2022 Oct 19.
Abstract: Preeclampsia (PE) is an obstetric disorder. N6-methyladenosine (m6A) modification is related to PE trophoblast biological behaviors. This study explored the mechanism of m6A-modified circSETD2 in trophoblast biological behaviors. Chorionic trophoblast ...
Specific and sensitive GC-MS analysis of hypusine, N ε -(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study.
Publication Type: Academic Journal
Source(s): Amino acids [Amino Acids] 2022 Jul; Vol. 54 (7), pp. 1083-1099. Date of Electronic Publication: 2022 Mar 03.
Abstract: Hypusination is a unique two-step enzymatic post-translational modification of the N ε -amino group of lysine-50 of the eukaryotic initiation factor 5A (eIF5A). We developed a specific and sensitive gas chromatography-mass spectrometry (GC-MS) method f...
Bi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder.
Publication Type: Academic Journal
Source(s): American journal of human genetics [Am J Hum Genet] 2022 Aug 04; Vol. 109 (8), pp. 1549-1558. Date of Electronic Publication: 2022 Jul 19.
Abstract: Deoxyhypusine hydroxylase (DOHH) is the enzyme catalyzing the second step in the post-translational synthesis of hypusine [N ε -(4-amino-2-hydroxybutyl)lysine] in the eukaryotic initiation factor 5A (eIF5A). Hypusine is formed exclusively in eIF5A by t...
Plasma Levels of Free N Ɛ -Carboxymethyllysine (CML) after Different Oral Doses of CML in Rats and after the Intake of Different Breakfasts in Humans: Postprandial Plasma Level of sRAGE in Humans.
Publication Type: Academic Journal
Source(s): Nutrients [Nutrients] 2022 Apr 30; Vol. 14 (9). Date of Electronic Publication: 2022 Apr 30.
Abstract: N-carboxymethyl-lysine (CML) and other dietary advanced glycation end-products (AGEs) are chemically modified amino acids with potential toxicological effects putatively related to their affinity with the receptor for AGEs (RAGE). The goal of this stud...
Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment.
Publication Type: Academic Journal
Source(s): Amino acids [Amino Acids] 2022 Apr; Vol. 54 (4), pp. 485-499. Date of Electronic Publication: 2021 Jul 17.
Abstract: Hypusine [N ε -(4-amino-2-hydroxybutyl)lysine] is a derivative of lysine that is formed post-translationally in the eukaryotic initiation factor 5A (eIF5A). Its occurrence at a single site in one cellular protein defines hypusine synthesis as one of th...
Identification of alternative protein targets of glutamate-ureido-lysine associated with PSMA tracer uptake in prostate cancer cells.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jan 25; Vol. 119 (4).
Abstract: Prostate-specific membrane antigen (PSMA) is highly overexpressed in most prostate cancers and is clinically visualized using PSMA-specific probes incorporating glutamate-ureido-lysine (GUL). PSMA is effectively absent from certain high-mortality, trea...
The Metabolite Saccharopine Impairs Neuronal Development by Inhibiting the Neurotrophic Function of Glucose-6-Phosphate Isomerase.
Publication Type: Academic Journal
Source(s): The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2022 Mar 30; Vol. 42 (13), pp. 2631-2646. Date of Electronic Publication: 2022 Feb 08.
Abstract: Mutations in the Aminoadipate-Semialdehyde Synthase ( AASS ) gene encoding α-aminoadipic semialdehyde synthase lead to hyperlysinemia-I, a benign metabolic variant without clinical significance, and hyperlysinemia-II with developmental delay and intell...