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Advanced Search Results For "MALARIA"

1 - 10 of 151,513 results for
 "MALARIA"
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Structural organization and sequence diversity of the complete nucleotide sequence encoding the Plasmodium malariae merozoite surface protein-1.

Publication Type: Academic Journal

Source(s): Scientific reports [Sci Rep] 2022 Sep 16; Vol. 12 (1), pp. 15591. Date of Electronic Publication: 2022 Sep 16.

Abstract: The merozoite surface protein-1 (MSP1) is a prime candidate for an asexual blood stage vaccine against malaria. However, polymorphism in this antigen could compromise the vaccine's efficacy. Although the extent of sequence variation in MSP1 has been an...

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Plasmodium vivax transmission-blocking vaccines: Progress, challenges and innovation.

Publication Type: Academic Journal

Source(s): Parasitology international [Parasitol Int] 2022 Apr; Vol. 87, pp. 102525. Date of Electronic Publication: 2021 Dec 09.

Abstract: Existing control measures have significantly reduced malaria morbidity and mortality in the last two decades, although these reductions are now stalling. Significant efforts have been undertaken to develop malaria vaccines. Recently, extensive progress...

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Amazonian Anopheles with low numbers of oocysts transmit Plasmodium vivax sporozoites during a blood meal.

Publication Type: Academic Journal

Source(s): Scientific reports [Sci Rep] 2022 Nov 14; Vol. 12 (1), pp. 19442. Date of Electronic Publication: 2022 Nov 14.

Abstract: Anopheles darlingi is the main malarial vector in the Brazilian Amazon region. An. nuneztovari s.l., An. triannulatus s.l., An. evansae, and An. benarrochi s.l. do not have a defined role as malarial vectors, although they have been found to be natural...

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A Malaria Vaccine for Africa - An Important Step in a Century-Long Quest.

Publication Type: Academic Journal

Source(s): The New England journal of medicine [N Engl J Med] 2022 Mar 17; Vol. 386 (11), pp. 1005-1007. Date of Electronic Publication: 2022 Mar 12.

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Diagnosis, Treatment, and Prevention of Malaria in the US: A Review.

Publication Type: Academic Journal

Source(s): JAMA [JAMA] 2022 Aug 02; Vol. 328 (5), pp. 460-471.

Abstract: Importance: Malaria is caused by protozoa parasites of the genus Plasmodium and is diagnosed in approximately 2000 people in the US each year who have returned from visiting regions with endemic malaria. The mortality rate from malaria is approximately...

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Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria.

Publication Type: Academic Journal

Source(s): The New England journal of medicine [N Engl J Med] 2022 Aug 04; Vol. 387 (5), pp. 397-407.

Abstract: Background: New approaches for the prevention and elimination of malaria, a leading cause of illness and death among infants and young children globally, are needed.Methods: We conducted a phase 1 clinical trial to assess the safety and pharmacokinetic...

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Comparative efficacy and safety of the artemisinin derivatives compared to quinine for treating severe malaria in children and adults: A systematic update of literature and network meta-analysis.

Publication Type: Academic Journal

Source(s): PloS one [PLoS One] 2022 Jul 20; Vol. 17 (7), pp. e0269391. Date of Electronic Publication: 2022 Jul 20 (Print Publication: 2022).

Abstract: Background: The artemisinin derivatives are the preferred antimalaria drugs for treating severe Plasmodium falciparum malaria. However, their clinical effectiveness compared to each other is unknown. Our objective, therefore, was to evaluate the effica...

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Plasmodium vivax - How hidden reservoirs hinder global malaria elimination.

Publication Type: Academic Journal

Source(s): Parasitology international [Parasitol Int] 2022 Apr; Vol. 87, pp. 102526. Date of Electronic Publication: 2021 Dec 08.

Abstract: Plasmodium vivax is the most geographically widespread human malaria parasite. Global malaria efforts have been less successful at reducing the burden of P. vivax compared to P. falciparum, owing to the unique biology and related treatment complexity o...

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Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya.

Publication Type: Academic Journal

Source(s): PloS one [PLoS One] 2022 Apr 07; Vol. 17 (4), pp. e0266394. Date of Electronic Publication: 2022 Apr 07 (Print Publication: 2022).

Abstract: Background: Leading transmission-blocking vaccine candidates such as Plasmodium falciparum surface protein 25 (Pfs25 gene) may undergo antigenic alterations which may render them ineffective or allele-specific. This study examines the level of genetic ...

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Standard Membrane Feeding Assay for Malaria Transmission Studies.

Publication Type: Academic Journal

Source(s): Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2410, pp. 597-606.

Abstract: Traditional and modern approaches have been applied to combat the malaria disease. Malaria eradication is a priority in several developing countries. Transmission-blocking vaccines are one of the suggested solutions for malaria eradication. Therefore, ...

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