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Advanced Search Results For "MATRICES"

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 "MATRICES"
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Cluster analysis of extracellular matrix biomarkers predicts the development of impaired systolic function within 1 year of acute myocardial infarction.

Publication Type: Academic Journal

Source(s): Heart and vessels [Heart Vessels] 2022 Dec; Vol. 37 (12), pp. 2029-2038. Date of Electronic Publication: 2022 Jul 27.

Abstract: The clinical utility of combining extracellular matrix (ECM) biomarkers to predict the development of impaired systolic function following acute myocardial infarction (AMI) remains largely undetermined. A combination of ELISA and multiplexing assays we...

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Alterations of the Extracellular Matrix in Colorectal Carcinoma.

Publication Type: Academic Journal

Source(s): Genetic testing and molecular biomarkers [Genet Test Mol Biomarkers] 2022 Oct; Vol. 26 (10), pp. 468-475. Date of Electronic Publication: 2022 Oct 10.

Abstract: Background: The process of proliferation and invasion of tumor cells depends on changes in the extracellular matrix (ECM) through the activation of enzymes and alterations in the profile of ECM components. Our aims were to investigate the mRNA...

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Development of a putative Zn 2+ -chelating but highly selective MMP-13 inhibitor.

Publication Type: Academic Journal

Source(s): Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Nov 15; Vol. 76, pp. 129014. Date of Electronic Publication: 2022 Oct 04.

Abstract: Starting from an already known MMP-13 inhibitor, 1, we pursued an SAR-approach focusing on optimizing interactions close to the Zn 2+ binding site of the enzyme. We found the oxetane containing compound 32 (MMP-13 IC 50  = 42 nM), which exhibited compl...

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Matrix Bound Nanovesicles Have Tissue-Specific Characteristics That Suggest a Regulatory Role.

Publication Type: Academic Journal

Source(s): Tissue engineering. Part A [Tissue Eng Part A] 2022 Nov; Vol. 28 (21-22), pp. 879-892. Date of Electronic Publication: 2022 Oct 03.

Abstract: Recent studies have identified an extracellular vesicle population that is tightly anchored within the extracellular matrix (ECM) of tissues and organs until released by matrix turnover events. Evidence suggests that these matrix-bound nanovesicles (MB...

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Functionally significant polymorphisms of the MMP9 gene are associated with primary open-angle glaucoma in the population of Russia.

Publication Type: Academic Journal

Source(s): European journal of ophthalmology [Eur J Ophthalmol] 2022 Nov; Vol. 32 (6), pp. 3208-3219. Date of Electronic Publication: 2022 Mar 07.

Abstract: Purpose: The aim of this study was to investigate the role of functionally significant loci of the matrix metalloproteinases genes 1, 3, 9 ( MMP1, MMP3, and MMP9 ) in the development of primary open-angle glaucoma (POAG) in Caucasians of the Central re...

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Matrix Metalloproteinase Gene Polymorphisms Are Associated with Breast Cancer in the Caucasian Women of Russia.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Oct 20; Vol. 23 (20). Date of Electronic Publication: 2022 Oct 20.

Abstract: We conducted this study to explore the association between matrix metalloproteinase ( MMP ) gene polymorphisms and breast cancer (BC) risk in the Caucasian women of Russia. In total, 358 affected (BC) and 746 unaffected (cancer-free) women were include...

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Discovery of Highly Potent and Selective Matrix Metalloproteinase-7 Inhibitors by Hybridizing the S1' Subsite Binder with Short Peptides.

Publication Type: Academic Journal

Source(s): Journal of medicinal chemistry [J Med Chem] 2022 Oct 13; Vol. 65 (19), pp. 13253-13263. Date of Electronic Publication: 2022 Sep 22.

Abstract: Matrix metalloproteinase-7 (MMP-7) has emerged as a protein playing important roles in both physiological and pathophysiological processes. Despite the growing interest in MMP-7 as a potential therapeutic target for diseases including cancer and fibros...

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Identification of hub genes and candidate herbal treatment in obesity through integrated bioinformatic analysis and reverse network pharmacology.

Publication Type: Academic Journal

Source(s): Scientific reports [Sci Rep] 2022 Oct 12; Vol. 12 (1), pp. 17113. Date of Electronic Publication: 2022 Oct 12.

Authors:

Abstract: Obesity is a global epidemic elevating the risk of various metabolic disorders. As there is a lack of effective drugs to treat obesity, we combined bioinformatics and reverse network pharmacology in this study to identify effective herbs to treat obesi...

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A pan-cancer analysis of matrisome proteins reveals CTHRC1 and a related network as major ECM regulators across cancers.

Publication Type: Academic Journal

Source(s): PloS one [PLoS One] 2022 Oct 03; Vol. 17 (10), pp. e0270063. Date of Electronic Publication: 2022 Oct 03 (Print Publication: 2022).

Abstract: The extracellular matrix in the tumour microenvironment can regulate cancer cell growth and progression. A pan-cancer analysis of TCGA data from 30 cancer types, identified the top 5% of matrisome genes with amplifications or deletions in their copy nu...

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5-Aza-dC promotes T-cell acute lymphoblastic leukemia cell invasion via downregulation of DNMT1 and upregulation of MMP-2 and MMP-9.

Publication Type: Academic Journal

Source(s): Experimental hematology [Exp Hematol] 2022 Oct; Vol. 114, pp. 43-53.e2. Date of Electronic Publication: 2022 Jul 29.

Authors:

Abstract: 5-Aza-2'-deoxycytidine (5-Aza-dC) is a demethylation agent known to deplete DNA methyltransferases (DNMTs) in leukemia cancer cells, and can restore the expression of their target genes in Jurkat cells. The goal of this study was to discern the potenti...

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