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Gene expression genetics of the striatum of Diversity Outbred mice.
Publication Type: Academic Journal
Source(s): Scientific data [Sci Data] 2023 Aug 05; Vol. 10 (1), pp. 522. Date of Electronic Publication: 2023 Aug 05.
Abstract: Brain transcriptional variation is a heritable trait that mediates complex behaviors, including addiction. Expression quantitative trait locus (eQTL) mapping reveals genomic regions harboring genetic variants that influence transcript abundance. In thi...
A study of the influence of genetic variance and sex on the density and thickness of the calvarial bone in collaborative cross mice.
Publication Type: Academic Journal
Source(s): Animal models and experimental medicine [Animal Model Exp Med] 2023 Aug; Vol. 6 (4), pp. 355-361. Date of Electronic Publication: 2023 Jul 13.
Abstract: Background: Bone microarchitecture is affected by multiple genes, each having a small effect on the external appearance. It is thus challenging to characterize the genes and their specific effect on bone thickness and porosity. The purpose of this stud...
Integrative analysis of hepatic transcriptional profiles reveals genetic regulation of atherosclerosis in hyperlipidemic Diversity Outbred-F1 mice.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2023 Jun 10; Vol. 13 (1), pp. 9475. Date of Electronic Publication: 2023 Jun 10.
Abstract: Atherogenesis is an insipidus but precipitating process leading to serious consequences of many cardiovascular diseases (CVD). Numerous genetic loci contributing to atherosclerosis have been identified in human genome-wide association studies, but thes...
Genetic Differences between 129S Substrains Affect Antiretroviral Immune Responses.
Publication Type: Academic Journal
Source(s): Journal of virology [J Virol] 2023 May 31; Vol. 97 (5), pp. e0193022. Date of Electronic Publication: 2023 Apr 24.
Abstract: Inbred mouse lines vary in their ability to mount protective antiretroviral immune responses, and even closely related strains can exhibit opposing phenotypes upon retroviral infection. Here, we found that 129S mice inherit a previously unknown mechani...
The DNA Damage Sensor MRE11 Regulates Efficient Replication of the Autonomous Parvovirus Minute Virus of Mice.
Publication Type: Academic Journal
Source(s): Journal of virology [J Virol] 2023 May 31; Vol. 97 (5), pp. e0046123. Date of Electronic Publication: 2023 Apr 26.
Abstract: Parvoviruses are single-stranded DNA viruses that utilize host proteins to vigorously replicate in the nuclei of host cells, leading to cell cycle arrest. The autonomous parvovirus, minute virus of mice (MVM), forms viral replication centers in the nuc...
The Autonomous Parvovirus Minute Virus of Mice Localizes to Cellular Sites of DNA Damage Using ATR Signaling.
Publication Type: Academic Journal
Source(s): Viruses [Viruses] 2023 May 25; Vol. 15 (6). Date of Electronic Publication: 2023 May 25.
Abstract: Minute Virus of Mice (MVM) is an autonomous parvovirus of the Parvoviridae family that replicates in mouse cells and transformed human cells. MVM genomes localize to cellular sites of DNA damage with the help of their essential non-structural phosphopr...
Genomes of the autonomous parvovirus minute virus of mice induce replication stress through RPA exhaustion.
Publication Type: Academic Journal
Source(s): PLoS pathogens [PLoS Pathog] 2023 May 30; Vol. 19 (5), pp. e1011203. Date of Electronic Publication: 2023 May 30 (Print Publication: 2023).
Abstract: The oncolytic autonomous parvovirus Minute Virus of Mice (MVM) establishes infection in the nuclear environment by usurping host DNA damage signaling proteins in the vicinity of cellular DNA break sites. MVM replication induces a global cellular DNA Da...
Electrostatic Screening, Acidic pH and Macromolecular Crowding Increase the Self-Assembly Efficiency of the Minute Virus of Mice Capsid In Vitro.
Publication Type: Academic Journal
Source(s): Viruses [Viruses] 2023 Apr 25; Vol. 15 (5). Date of Electronic Publication: 2023 Apr 25.
Abstract: The hollow protein capsids from a number of different viruses are being considered for multiple biomedical or nanotechnological applications. In order to improve the applied potential of a given viral capsid as a nanocarrier or nanocontainer, specific ...
Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population.
Publication Type: Academic Journal
Source(s): G3 (Bethesda, Md.) [G3 (Bethesda)] 2023 Apr 11; Vol. 13 (4).
Abstract: Multiparental populations (MPPs) encompass greater genetic diversity than traditional experimental crosses of two inbred strains, enabling broader surveys of genetic variation underlying complex traits. Two such mouse MPPs are the Collaborative Cross (...
Mousepost 2.0, a major expansion of the resource.
Publication Type: Academic Journal
Source(s): Nucleic acids research [Nucleic Acids Res] 2023 Feb 28; Vol. 51 (4), pp. 1652-1661.
Abstract: The Mousepost 1.0 online search tool, launched in 2017, allowed to search for variations in all protein-coding gene sequences of 36 sequenced mouse inbred strains, compared to the reference strain C57BL/6J, which could be linked to strain-specific phen...