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Advanced Search Results For "MICE"

1 - 10 of 2,111,718 results for
 "MICE"
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Lethal Swine Acute Diarrhea Syndrome Coronavirus Infection in Suckling Mice.

Publication Type: Academic Journal

Source(s): Journal of virology [J Virol] 2022 Sep 14; Vol. 96 (17), pp. e0006522. Date of Electronic Publication: 2022 Aug 22.

Abstract: Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently emerging bat-borne coronavirus responsible for high mortality rates in piglets. In vitro studies have indicated that SADS-CoV has a wide tissue tropism in different hosts, including hum...

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Common human genetic variants of APOE impact murine COVID-19 mortality.

Publication Type: Academic Journal

Source(s): Nature [Nature] 2022 Nov; Vol. 611 (7935), pp. 346-351. Date of Electronic Publication: 2022 Sep 21.

Abstract: Clinical outcomes of severe acute respiratory syndrome 2 (SARS-CoV-2) infection are highly heterogeneous, ranging from asymptomatic infection to lethal coronavirus disease 2019 (COVID-19). The factors underlying this heterogeneity remain insufficiently...

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An optimized visual loop mediated isothermal amplification assay for efficient detection of minute virus of mice with hydroxynaphthol blue dye.

Publication Type: Academic Journal

Source(s): Journal of virological methods [J Virol Methods] 2022 Oct; Vol. 308, pp. 114575. Date of Electronic Publication: 2022 Jul 05.

Authors:

Abstract: Minute virus of mice (MVM) is one of the most prevalent infectious agents in laboratory mouse colonies. In this study, we optimized a loop-mediated isothermal amplification (LAMP) assay using hydroxynaphthol blue (HNB) for rapid and visual detection of...

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Protein Myristoylation Plays a Role in the Nuclear Entry of the Parvovirus Minute Virus of Mice.

Publication Type: Academic Journal

Source(s): Journal of virology [J Virol] 2022 Sep 14; Vol. 96 (17), pp. e0111822. Date of Electronic Publication: 2022 Aug 11.

Abstract: Being nonpathogenic to humans, rodent parvoviruses (PVs) are naturally oncolytic viruses with great potential as anti-cancer agents. As these viruses replicate in the host cell nucleus, they must gain access to the nucleus during infection. The PV minu...

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[Generation of SARS-CoV-2 Mouse Model by Transient Expression of the Human ACE2 Gene Mediated by Intranasal Administration of AAV-hACE2].

Publication Type: Academic Journal

Source(s): Molekuliarnaia biologiia [Mol Biol (Mosk)] 2022 Sep-Oct; Vol. 56 (5), pp. 774-782.

Abstract: One of the most important steps in the development of drugs and vaccines against a new coronavirus infection is their testing on a relevant animal model. The laboratory mouse, with well-studied immunology, is the preferred mammalian model in experiment...

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Intramembranous bone regeneration in diversity outbred mice is heritable.

Publication Type: Academic Journal

Source(s): Bone [Bone] 2022 Nov; Vol. 164, pp. 116524. Date of Electronic Publication: 2022 Aug 24.

Abstract: There are over one million cases of failed bone repair in the U.S. annually, resulting in substantial patient morbidity and societal costs. Multiple candidate genes affecting bone traits such as bone mineral density have been identified in human subjec...

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Factors affecting robustness of anion exchange chromatography: Selective retention of minute virus of mice using membrane media.

Publication Type: Academic Journal

Source(s): Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2022 Nov 01; Vol. 1210, pp. 123449. Date of Electronic Publication: 2022 Sep 13.

Authors:

Abstract: Mobile and stationary phase factors were investigated in order to identify conditions for effective capture of minute virus of mice (MVM), a potential adventitious contaminant in biomanufacturing, using anion exchange membrane chromatography (AEX). The...

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The human EF1a promoter does not provide expression of the transgene in mice.

Publication Type: Academic Journal

Source(s): Transgenic research [Transgenic Res] 2022 Oct; Vol. 31 (4-5), pp. 525-535. Date of Electronic Publication: 2022 Aug 12.

Abstract: In this work, we set out to create mice susceptible to the SARS-CoV-2 coronavirus. To ensure the ubiquitous expression of the human ACE2 gene we used the human EF1a promoter. Using pronuclear microinjection of the transgene construct, we obtained six f...

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Genetic quality: a complex issue for experimental study reproducibility.

Publication Type: Academic Journal

Source(s): Transgenic research [Transgenic Res] 2022 Oct; Vol. 31 (4-5), pp. 413-430. Date of Electronic Publication: 2022 Jun 25.

Abstract: Laboratory animal research involving mice, requires consideration of many factors to be controlled. Genetic quality is one factor that is often overlooked but is essential for the generation of reproducible experimental results. Whether experimental re...

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Using the Collaborative Cross and Diversity Outbred Mice in Immunology.

Publication Type: Academic Journal

Source(s): Current protocols [Curr Protoc] 2022 Sep; Vol. 2 (9), pp. e547.

Abstract: The Collaborative Cross (CC) and the Diversity Outbred (DO) stock mouse panels are the most powerful murine genetics tools available to the genetics community. Together, they combine the strength of inbred animal models with the diversity of outbred po...

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