Advanced Search Results For "MITOGEN-activated protein kinase phosphatases"
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A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding.
Publication Type: Academic Journal
Source(s): The Journal of biological chemistry [J Biol Chem] 2022 Dec; Vol. 298 (12), pp. 102617. Date of Electronic Publication: 2022 Oct 19.
Abstract: The dual-specificity phosphatases responsible for the inactivation of the mitogen-activated protein kinases (MAPKs) are designated as the MAPK phosphatases (MKPs). We demonstrated previously that MKP5 is regulated through a novel allosteric site sugges...
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?
Publication Type: Academic Journal
Source(s): Annual review of pharmacology and toxicology [Annu Rev Pharmacol Toxicol] 2023 Jan 20; Vol. 63, pp. 617-636.
Abstract: Phosphatases and kinases maintain an equilibrium of dephosphorylated and phosphorylated proteins, respectively, that are required for critical cellular functions. Imbalance in this equilibrium or irregularity in their function causes unfavorable cellul...
DUSP22 rearrangement is associated with a distinctive immunophenotype but not outcome in patients with systemic ALK-negative anaplastic large cell lymphoma.
Publication Type: Academic Journal
Source(s): Haematologica [Haematologica] 2023 Jun 01; Vol. 108 (6), pp. 1604-1615. Date of Electronic Publication: 2023 Jun 01.
Abstract: DUSP22 rearrangement (R) has been associated with a favorable outcome in systemic ALK-negative anaplastic large cell lymphoma (ALCL). However, a recent study found that patients with DUSP22-R ALK-negative ALCL have a poorer prognosis than was reported ...
ADSC secretome constrains NK cell activity by attenuating IL-2-mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4.
Publication Type: Academic Journal
Source(s): Stem cell research & therapy [Stem Cell Res Ther] 2023 Nov 14; Vol. 14 (1), pp. 329. Date of Electronic Publication: 2023 Nov 14.
Abstract: Background: Mesenchymal stem cells (MSCs) have immunomodulatory properties and therapeutic effects on autoimmune diseases through their secreted factors, referred to as the secretome. However, the specific key factors of the MSC secretome and their mec...
Identification of mitogen-activated protein kinase phosphatase-1 (MKP-1) protein partners using tandem affinity purification and mass spectrometry.
Publication Type: Academic Journal
Source(s): Pharmacological reports : PR [Pharmacol Rep] 2023 Apr; Vol. 75 (2), pp. 474-481. Date of Electronic Publication: 2023 Mar 24.
Abstract: Background: According to the World Health Organization Report, depressive disorders affect about 10% of the population. The molecular mechanism of the pathogenesis of depression is still not well understood. The new findings point to phosphatases as po...
Acute Endoplasmic Reticulum Stress Suppresses Hepatic Gluconeogenesis by Stimulating MAPK Phosphatase 3 Degradation.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Oct 25; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 25.
Abstract: Drug-induced liver injury (DILI) is a widespread and harmful disease, and is closely linked to acute endoplasmic reticulum (ER) stress. Previous reports have shown that acute ER stress can suppress hepatic gluconeogenesis and even leads to hypoglycemia...
Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer.
Publication Type: Academic Journal
Source(s): Breast cancer research : BCR [Breast Cancer Res] 2022 Jul 18; Vol. 24 (1), pp. 51. Date of Electronic Publication: 2022 Jul 18.
Abstract: Aim: Deregulated signaling pathways are a hallmark feature of oncogenesis and driver of tumor progression. Dual specificity protein phosphatase 4 (DUSP4) is a critical negative regulator of the mitogen-activated protein kinase (MAPK) pathway and is oft...
Dual specific phosphatases (DUSPs) in cardiac hypertrophy and failure.
Publication Type: Academic Journal
Source(s): Cellular signalling [Cell Signal] 2021 Aug; Vol. 84, pp. 110033. Date of Electronic Publication: 2021 Apr 29.
Abstract: Pressure overload and other stress stimuli elicit a host of adaptive and maladaptive signaling cascades that eventually lead to cardiac hypertrophy and heart failure. Among those, the mitogen-activated protein kinase (MAPK) signaling pathway has been s...
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Publication Type: Academic Journal
Source(s): Cell reports [Cell Rep] 2021 Jul 27; Vol. 36 (4), pp. 109421.
Abstract: Mitogen-activated protein kinases (MAPKs) are inactivated by dual-specificity phosphatases (DUSPs), the activities of which are tightly regulated during cell differentiation. Using knockdown screening and single-cell transcriptional analysis, we demons...
DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.
Publication Type: Academic Journal
Source(s): Life science alliance [Life Sci Alliance] 2023 Nov 15; Vol. 7 (2). Date of Electronic Publication: 2023 Nov 15 (Print Publication: 2024).
Abstract: Abnormal trophoblast function is associated with diseases such as recurrent spontaneous abortion, pre-eclampsia, and preterm birth, and endangers maternal and fetal health. However, the underlying regulatory mechanisms remain unclear. In this study, we...