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    • Identification and overcoming rituximab resistance in diffuse large B-cell lymphoma using next-generation sequencing.

    Publication Type: Academic Journal

    Source(s): The Korean journal of internal medicine [Korean J Intern Med] 2023 Nov; Vol. 38 (6), pp. 893-902. Date of Electronic Publication: 2023 Aug 21.

    Authors:

    Abstract: Background/aims: Although rituximab, an antiCD20 monoclonal antibody, has dramatically improved the clinical outcomes of diffuse large B-cell lymphoma, rituximab resistance remains a challenge.Methods: We developed a rituximab-resistant cell line (RRCL...

    Physical exercise elicits UPR mt in the skeletal muscle: The role of c-Jun N-terminal kinase.

    Publication Type: Academic Journal

    Source(s): Molecular metabolism [Mol Metab] 2023 Dec; Vol. 78, pp. 101816. Date of Electronic Publication: 2023 Oct 10.

    Abstract: Objective: The mitochondrial unfolded protein response (UPR mt ) is an adaptive cellular response to stress to ensure mitochondrial proteostasis and function. Here we explore the capacity of physical exercise to induce UPR mt in the skeletal muscle.Met...

    Toll-like receptor 4 promotes the inflammatory response in septic acute kidney injury by promoting p38 mitogen-activated protein kinase phosphorylation.

    Publication Type: Academic Journal

    Source(s): Journal of bioenergetics and biomembranes [J Bioenerg Biomembr] 2023 Oct; Vol. 55 (5), pp. 353-363. Date of Electronic Publication: 2023 Aug 22.

    Authors:

    Abstract: Septic acute kidney injury (AKI) contributes to the mortality and morbidity of sepsis patients. Toll-like Receptor 4 (TLR4) has prominent roles in septic AKI. This study investigated the functions of TLR4 in septic AKI. A septic AKI mouse model was est...

    Resveratrol improves the prognosis of rats after spinal cord injury by inhibiting mitogen-activated protein kinases signaling pathway.

    Publication Type: Academic Journal

    Source(s): Scientific reports [Sci Rep] 2023 Nov 13; Vol. 13 (1), pp. 19723. Date of Electronic Publication: 2023 Nov 13.

    Authors:

    Abstract: Spinal cord injury (SCI) is a serious condition that results in irreparable nerve damage and severe loss of motor or sensory function. Resveratrol (3,4',5-trihy- droxystilbene) is a naturally occurring plant-based polyphenol that has demonstrated power...

    Mitogen-Activated Protein Kinase and Exploratory Nuclear Receptor Crosstalk in Cancer Immunotherapy.

    Publication Type: Academic Journal

    Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Sep 26; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 26.

    Authors:

    Abstract: The three major mitogen-activated protein kinase (MAPK) pathways (ERK1/2, p38, and JNK/SAPK) are upstream regulators of the nuclear receptor superfamily (NRSF). These ligand-activated transcription factors are divided into subclasses comprising recepto...

    Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly increases disease severity in a mouse model of multiple sclerosis.

    Publication Type: Academic Journal

    Source(s): Journal of neuroimmunology [J Neuroimmunol] 2023 Sep 15; Vol. 382, pp. 578152. Date of Electronic Publication: 2023 Jul 12.

    Abstract: The c-Jun amino terminal kinases (JNKs) regulate transcription, and studies suggest they contribute to neuropathology in the EAE model of MS. To examine the role of the JNK3 isoform, we compared EAE in JNK3 null mice to wild type (WT) littermates. Alth...

    P38 kinase in gastrointestinal cancers.

    Publication Type: Academic Journal

    Source(s): Cancer gene therapy [Cancer Gene Ther] 2023 Sep; Vol. 30 (9), pp. 1181-1189. Date of Electronic Publication: 2023 May 29.

    Abstract: Gastrointestinal cancers are a leading cause of cancer morbidity and mortality worldwide with 4.2 million new cases and 3.2 million deaths estimated in 2020. Despite the advances in primary and adjuvant therapies, patients still develop distant metasta...

    Differential Modulation of the Phosphoproteome by the MAP Kinases Isoforms p38α and p38β.

    Publication Type: Academic Journal

    Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Aug 04; Vol. 24 (15). Date of Electronic Publication: 2023 Aug 04.

    Abstract: The p38 members of the mitogen-activated protein kinases (MAPKs) family mediate various cellular responses to stress conditions, inflammatory signals, and differentiation factors. They are constitutively active in chronic inflammatory diseases and some...

    Hepatic p38α MAPK controls gluconeogenesis via FOXO1 phosphorylation at S273 during glucagon signalling in mice.

    Publication Type: Academic Journal

    Source(s): Diabetologia [Diabetologia] 2023 Jul; Vol. 66 (7), pp. 1322-1339. Date of Electronic Publication: 2023 May 19.

    Authors:

    Abstract: Aims/hypothesis: Hyperglucagonaemia-stimulated hepatic glucose production (HGP) contributes to hyperglycaemia during type 2 diabetes. A better understanding of glucagon action is important to enable efficient therapies to be developed for the treatment...

    Synthesis-accessibility-oriented design of c-Jun N-terminal kinase 1 inhibitor.

    Publication Type: Academic Journal

    Source(s): European journal of medicinal chemistry [Eur J Med Chem] 2023 Aug 05; Vol. 256, pp. 115442. Date of Electronic Publication: 2023 May 03.

    Authors:

    Abstract: Idiopathic pulmonary fibrosis (IPF) is a severe and progressive lung disease with poor prognosis and limited treatment options. The c-Jun N-Terminal Kinase 1 (JNK1), a key component of the MAPK pathway, has been implicated in the pathogenesis of IPF an...

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