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Advanced Search Results For "MOLECULES"

1 - 10 of 232,611 results for
 "MOLECULES"
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LINC01146/F11R facilitates growth and metastasis of prostate cancer under the regulation of TGF-β.

Publication Type: Academic Journal

Source(s): The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2023 Jan; Vol. 225, pp. 106193. Date of Electronic Publication: 2022 Sep 23.

Authors:

Abstract: The effect of long intergenic non-protein coding RNAs (lncRNAs) was verified in prostate cancer (PCa), but the mechanism of LINC01146 in PCa is unclear. Bioinformatics was applied to analyze LINC01146 expression in PCa and predict target genes of LINC0...

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[Prenatal diagnosis of partial deletion of NRXN1 gene with combined CNV-seq and qPCR assays].

Publication Type: Academic Journal

Source(s): Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2022 Nov 10; Vol. 39 (11), pp. 1200-1204.

Authors:

Abstract: Objective: To summarize the genetic diagnosis, low-depth copy number variation sequencing (CNV-seq) and prenatal finding in 7 fetuses with 2p16.3 deletions only involving the NRXN1 gene.Methods: The 7 fetuses have all been found to have loss of heteroz...

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Structural insights into the contactin 1 - neurofascin 155 adhesion complex.

Publication Type: Academic Journal

Source(s): Nature communications [Nat Commun] 2022 Nov 03; Vol. 13 (1), pp. 6607. Date of Electronic Publication: 2022 Nov 03.

Abstract: Cell-surface expressed contactin 1 and neurofascin 155 control wiring of the nervous system and interact across cells to form and maintain paranodal myelin-axon junctions. The molecular mechanism of contactin 1 - neurofascin 155 adhesion complex format...

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Phenotypic and functional characterization of the CD6-ALCAM T-cell co-stimulatory pathway after allogeneic cell transplantation.

Publication Type: Academic Journal

Source(s): Haematologica [Haematologica] 2022 Nov 01; Vol. 107 (11), pp. 2617-2629. Date of Electronic Publication: 2022 Nov 01.

Abstract: CD6 is a co-stimulatory receptor expressed on T cells that binds activated leukocyte cell adhesion molecule (ALCAM), expressed on antigen presenting cells, epithelial and endothelial tissues. The CD6-ALCAM pathway plays an integral role in modulating T...

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Crystal structure of Ankyrin-G in complex with a fragment of Neurofascin reveals binding mechanisms required for integrity of the axon initial segment.

Publication Type: Academic Journal

Source(s): The Journal of biological chemistry [J Biol Chem] 2022 Sep; Vol. 298 (9), pp. 102272. Date of Electronic Publication: 2022 Jul 16.

Authors:

Abstract: The axon initial segment (AIS) has characteristically dense clustering of voltage-gated sodium channels (Nav), cell adhesion molecule Neurofascin 186 (Nfasc), and neuronal scaffold protein Ankyrin-G (AnkG) in neurons, which facilitates generation of an...

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Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis.

Publication Type: Academic Journal

Source(s): JCI insight [JCI Insight] 2022 Aug 22; Vol. 7 (16). Date of Electronic Publication: 2022 Aug 22.

Abstract: Expression of the tight junction-associated protein junctional adhesion molecule-A (JAM-A) is increased in sepsis, although the significance of this is unknown. Here, we show that septic JAM-A -/- mice have increased gut permeability, yet paradoxically...

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A GPI-anchored Neurexin 3 proteoform mediates dendritic inhibition.

Publication Type: Academic Journal

Source(s): Neuron [Neuron] 2022 Jul 06; Vol. 110 (13), pp. 2041-2044.

Authors:

Abstract: Neuronal wiring is facilitated by diverse synaptic adhesion proteins and their repertoire of alternatively spliced isoforms. In this issue of Neuron, Hauser et al. (2022) uncovered the role of a GPI-anchored neurexin 3 splice variant in inhibitory syna...

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LncRNA RUNX1-IT1 affects the differentiation of Th1 cells by regulating NrCAM transcription in Graves' disease.

Publication Type: Academic Journal

Source(s): Cell cycle (Georgetown, Tex.) [Cell Cycle] 2022 May; Vol. 21 (9), pp. 921-933. Date of Electronic Publication: 2022 Feb 27.

Abstract: Graves' disease (GD) is a kind of autoimmune diseases. The development of GD is closely related to the imbalance of Th1/Th2 generated by the differentiation of CD4 + T cells. This study was sought to clarify the role of lncRNA RUNX1-IT1 and explore the...

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ALCAM/CD166 Is Involved in the Binding and Uptake of Cancer-Derived Extracellular Vesicles.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 May 20; Vol. 23 (10). Date of Electronic Publication: 2022 May 20.

Abstract: Colorectal cancer (CRC) and ovarian cancer (OvC) patients frequently develop peritoneal metastasis, a condition associated with a very poor prognosis. In these cancers, tumor-derived extracellular vesicles (EVs) cause immunosuppression, facilitate the ...

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Junctional adhesion molecule C expression specifies a CD138low/neg multiple myeloma cell population in mice and humans.

Publication Type: Academic Journal

Source(s): Blood advances [Blood Adv] 2022 Apr 12; Vol. 6 (7), pp. 2195-2206.

Abstract: Deregulation such as overexpression of adhesion molecules influences cancer progression and survival. Metastasis of malignant cells from their primary tumor site to distant organs is the most common reason for cancer-related deaths. Junctional adhesion...

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