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A Novel Transgenic Mouse Model Implicates Sirt2 as a Promoter of Hepatocellular Carcinoma.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Aug2023, Vol. 24 Issue 16, p12618. 14p.
Abstract: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths globally. Incidence rates are steadily increasing, creating an unmet need for new therapeutic options. Recently, the inhibition of sirtuin-2 (Sirt2) was proposed as a potentia...
The Contribution of TRPA1 to Corneal Thermosensitivity and Blink Regulation in Young and Aged Mice.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Aug2023, Vol. 24 Issue 16, p12620. 19p.
Abstract: The role of TRPA1 in the thermosensitivity of the corneal cold thermoreceptor nerve endings was studied in young and aged mice. The contribution of the TRPA1-dependent activity to basal tearing and thermally-evoked blink was also explored. The corneal ...
Early Administration of the Phytocannabinoid Cannabidivarin Prevents the Neurobehavioral Abnormalities Associated with the Fmr1 -KO Mouse Model of Fragile X Syndrome.
Publication Type: Academic Journal
Source(s): Cells (2073-4409). Aug2023, Vol. 12 Issue 15, p1927. 25p.
Abstract: Phytocannabinoids, including the non-addictive cannabis component cannabidivarin (CBDV), have been reported to hold therapeutic potential in several neurodevelopmental disorders (NDDs). Nonetheless, the therapeutic value of phytocannabinoids for treati...
Finding an Appropriate Mouse Model to Study the Impact of a Treatment for Friedreich Ataxia on the Behavioral Phenotype.
Publication Type: Academic Journal
Source(s): Genes. Aug2023, Vol. 14 Issue 8, p1654. 20p.
Abstract: Friedreich ataxia (FRDA) is a progressive neurodegenerative disease caused by a GAA repeat in the intron 1 of the frataxin gene (FXN) leading to a lower expression of the frataxin protein. The YG8sR mice are Knock-Out (KO) for their murine frataxin gen...
Therapeutic Effect of C-Vx Substance in K18-hACE2 Transgenic Mice Infected with SARS-CoV-2.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Aug2023, Vol. 24 Issue 15, p11957. 12p.
Abstract: C-Vx is a bioprotective product designed to boost the immune system. This study aimed to determine the antiviral activity of the C-Vx substance against SARS-CoV-2 infection. The effect of C-Vx in K18-hACE2 transgenic mice against the SARS-CoV-2 virus w...
Aggregation-Inhibiting scFv-Based Therapies Protect Mice against AAV1/2-Induced A53T-α-Synuclein Overexpression.
Publication Type: Academic Journal
Source(s): Biomolecules (2218-273X). Aug2023, Vol. 13 Issue 8, p1203. 19p.
Abstract: To date, there is no cure for Parkinson's disease (PD). There is a pressing need for anti-neurodegenerative therapeutics that can slow or halt PD progression by targeting underlying disease mechanisms. Specifically, preventing the build-up of alpha-syn...
Oleocanthal Ameliorates Metabolic and Behavioral Phenotypes in a Mouse Model of Alzheimer's Disease.
Publication Type: Academic Journal
Source(s): Molecules. Jul2023, Vol. 28 Issue 14, p5592. 18p.
Abstract: Aging is a major risk factor for Alzheimer's disease (AD). AD mouse models are frequently used to assess pathology, behavior, and memory in AD research. While the pathological characteristics of AD are well established, our understanding of the changes...
Hyperacusis in the Adult Fmr1 -KO Mouse Model of Fragile X Syndrome: The Therapeutic Relevance of Cochlear Alterations and BKCa Channels.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Jul2023, Vol. 24 Issue 14, p11863. 14p.
Abstract: Hyperacusis, i.e., an increased sensitivity to sounds, is described in several neurodevelopmental disorders (NDDs), including Fragile X Syndrome (FXS). The mechanisms underlying hyperacusis in FXS are still largely unknown and effective therapies are l...
Sexual Dimorphism of Skeletal Muscle in a Mouse Model of Breast Cancer: A Functional and Molecular Analysis.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Jul2023, Vol. 24 Issue 14, p11669. 19p.
Abstract: Breast cancer incidence in men is statistically rare; however, given the lack of screening in males, more advanced stages at initial diagnosis result in lower 5-year survival rates for men with breast cancer compared to women. A sexual dimorphism, with...
Effective Healing of Staphylococcus aureus -Infected Wounds in Pig Cathelicidin Protegrin-1-Overexpressing Transgenic Mice.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Jul2023, Vol. 24 Issue 14, p11658. 14p.
Abstract: Antimicrobial peptides (AMPs) are promising alternatives to existing treatments for multidrug-resistant bacteria-infected wounds. Therefore, the effect of protegrin-1 (PG1), a potent porcine AMP with broad-spectrum activity, on wound healing was evalua...