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Metabolic differences and differentially expressed genes between C57BL/6J and C57BL/6N mice substrains.
Publication Type: Academic Journal
Source(s): PloS one [PLoS One] 2022 Dec 22; Vol. 17 (12), pp. e0271651. Date of Electronic Publication: 2022 Dec 22 (Print Publication: 2022).
Abstract: C57BL/6J (B6J) and C57BL/6N (B6N) mice are the most frequently used substrains in C57BL/6 (B6) inbred mice, serving as physiological models for in vivo studies and as background strains to build transgenic mice. However, the differences in metabolic ph...
The sex-specific metabolic signature of C57BL/6NRj mice during aging.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2022 Dec 06; Vol. 12 (1), pp. 21050. Date of Electronic Publication: 2022 Dec 06.
Abstract: Due to intact reactive oxygen species homeostasis and glucose metabolism, C57BL/6NRj mice are especially suitable to study cellular alterations in metabolism. We applied Nuclear Magnetic resonance spectroscopy to analyze five different tissues of this ...
Integrative analysis of hepatic transcriptional profiles reveals genetic regulation of atherosclerosis in hyperlipidemic Diversity Outbred-F1 mice.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2023 Jun 10; Vol. 13 (1), pp. 9475. Date of Electronic Publication: 2023 Jun 10.
Abstract: Atherogenesis is an insipidus but precipitating process leading to serious consequences of many cardiovascular diseases (CVD). Numerous genetic loci contributing to atherosclerosis have been identified in human genome-wide association studies, but thes...
Mousepost 2.0, a major expansion of the resource.
Publication Type: Academic Journal
Source(s): Nucleic acids research [Nucleic Acids Res] 2023 Feb 28; Vol. 51 (4), pp. 1652-1661.
Abstract: The Mousepost 1.0 online search tool, launched in 2017, allowed to search for variations in all protein-coding gene sequences of 36 sequenced mouse inbred strains, compared to the reference strain C57BL/6J, which could be linked to strain-specific phen...
Variation in Host Resistance to Blastomyces dermatitidis: Potential Use of Genetic Reference Panels and Advances in Immunophenotyping of Diverse Mouse Strains.
Publication Type: Academic Journal
Source(s): MBio [mBio] 2022 Feb 22; Vol. 13 (1), pp. e0340021. Date of Electronic Publication: 2022 Jan 04.
Abstract: Host genetic determinants that underpin variation in susceptibility to systemic fungal infection are poorly understood. Genes responsible for complex traits can be identified by correlating variation in phenotype with allele in founder strains of wild ...
Impaired dynamic X-chromosome inactivation maintenance in T cells is a feature of spontaneous murine SLE that is exacerbated in female-biased models.
Publication Type: Academic Journal
Source(s): Journal of autoimmunity [J Autoimmun] 2023 Sep; Vol. 139, pp. 103084. Date of Electronic Publication: 2023 Jul 01.
Abstract: Objective: Systemic lupus erythematosus (SLE) is a highly female-biased systemic autoimmune disease, but the molecular basis for this female bias remains incompletely elucidated. B and T lymphocytes from patients with SLE and female-biased mouse models...
A sulfonamide chalcone AMPK activator ameliorates hyperglycemia and diabetic nephropathy in db/db mice.
Publication Type: Academic Journal
Source(s): Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Sep; Vol. 165, pp. 115158. Date of Electronic Publication: 2023 Jul 18.
Abstract: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus (DM), which currently lacks effective treatments. AMP-activated protein kinase (AMPK) stimulation by chalcones, a class of polyphenols abundantly found in plants, is proposed as a...
Basophil responses in susceptible AKR mice upon infection with the intestinal helminth parasite Trichuris muris.
Publication Type: Academic Journal
Source(s): Parasite immunology [Parasite Immunol] 2023 Aug; Vol. 45 (8), pp. e12999. Date of Electronic Publication: 2023 Jul 06.
Abstract: Intestinal helminth infection promotes a Type 2 inflammatory response in resistant C57BL/6 mice that is essential for worm clearance. The study of inbred mouse strains has revealed factors that are critical for parasite resistance and delineated the ro...
Circadian Responses to Light in the BTBR Mouse.
Publication Type: Academic Journal
Source(s): Journal of biological rhythms [J Biol Rhythms] 2022 Oct; Vol. 37 (5), pp. 498-515. Date of Electronic Publication: 2022 Jun 20.
Abstract: Animals with altered freerunning periods are valuable in understanding properties of the circadian clock. Understanding the relationship between endogenous clock properties, entrainment, and influence of light in terms of parametric and non-parametric ...
FTZ promotes islet β-cell regeneration in T1DM mice via the regulation of nuclear proliferation factors.
Publication Type: Academic Journal
Source(s): Journal of ethnopharmacology [J Ethnopharmacol] 2023 Oct 28; Vol. 315, pp. 116564. Date of Electronic Publication: 2023 May 25.
Abstract: Ethnopharmacological Relevance: Fufang-Zhenzhu-Tiaozhi capsule (FTZ), a Traditional Chinese Medicine (TCM) patent prescription commonly used in clinical practice, has a significant curative effect on hyperglycemia and hyperlipidemia. Previous studies h...