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Autopolyploidy, Allopolyploidy, and Phylogenetic Networks with Horizontal Arcs.
Publication Type: Academic Journal
Source(s): Bulletin of mathematical biology [Bull Math Biol] 2023 Apr 06; Vol. 85 (5), pp. 40. Date of Electronic Publication: 2023 Apr 06.
Abstract: Polyploidization is an evolutionary process by which a species acquires multiple copies of its complete set of chromosomes. The reticulate nature of the signal left behind by it means that phylogenetic networks offer themselves as a framework to recons...
Assessment of food effects during clinical development.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Mar 25; Vol. 635, pp. 122758. Date of Electronic Publication: 2023 Feb 18.
Abstract: Food-drug interactions frequently hamper oral drug development due to various physicochemical, physiological and formulation-dependent mechanisms. This has stimulated the development of a range of promising biopharmaceutical assessment tools which, how...
Solute transport in the brain tissue: what are the key biophysical parameters tying in vivo and in vitro studies together?
Publication Type: Academic Journal
Source(s): Biomaterials science [Biomater Sci] 2023 May 16; Vol. 11 (10), pp. 3450-3460. Date of Electronic Publication: 2023 May 16.
Abstract: The mechanisms of solute transport in brain tissues are still under debate. The medical relevance of this topic has put the blood-brain barrier and the mechanisms of solute transport through the brain parenchyma in the spotlight, notably in the context...
A 'Portfolio of Model Approximations' approach to understanding invasion success with vector-borne disease.
Publication Type: Academic Journal
Source(s): Mathematical biosciences [Math Biosci] 2023 Apr; Vol. 358, pp. 108994. Date of Electronic Publication: 2023 Mar 11.
Abstract: The central challenge of mathematical modeling of real-world systems is to strike an appropriate balance between insightful abstraction and detailed accuracy. Models in mathematical epidemiology frequently tend to either extreme, focusing on analytical...
Progress in biological age research.
Publication Type: Academic Journal
Source(s): Frontiers in public health [Front Public Health] 2023 Apr 12; Vol. 11, pp. 1074274. Date of Electronic Publication: 2023 Apr 12 (Print Publication: 2023).
Abstract: Biological age (BA) is a common model to evaluate the function of aging individuals as it may provide a more accurate measure of the extent of human aging than chronological age (CA). Biological age is influenced by the used biomarkers and standards in...
A novel mechanism measurement of predator interference in predator-prey models.
Publication Type: Academic Journal
Source(s): Journal of mathematical biology [J Math Biol] 2023 Apr 27; Vol. 86 (5), pp. 84. Date of Electronic Publication: 2023 Apr 27.
Abstract: A characteristic of ecosystems is the existence of manifold of independencies which are highly complex. Various mathematical models have made considerable contributions in gaining a better understanding of the predator-prey interactions. The main compo...
Nonlinear diffusion in multi-patch logistic model.
Publication Type: Academic Journal
Source(s): Journal of mathematical biology [J Math Biol] 2023 Jun 06; Vol. 87 (1), pp. 1. Date of Electronic Publication: 2023 Jun 06.
Abstract: We examine a multi-patch model of a population connected by nonlinear asymmetrical migration, where the population grows logistically on each patch. Utilizing the theory of cooperative differential systems, we prove the global stability of the model. I...
Eco-evolutionary dynamics in microbial interactions.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2023 Jun 03; Vol. 13 (1), pp. 9042. Date of Electronic Publication: 2023 Jun 03.
Abstract: Microbes play an important role in ecosystem functioning and human health. A key feature of microbial interactions is a feedback system in which they modify the physical environment and react to it. Recently, it has been shown that the ecological conse...
Transient mutation bias increases the predictability of evolution on an empirical genotype-phenotype landscape.
Publication Type: Academic Journal
Source(s): Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2023 May 22; Vol. 378 (1877), pp. 20220043. Date of Electronic Publication: 2023 Apr 03.
Abstract: Predicting how a population will likely navigate a genotype-phenotype landscape requires consideration of selection in combination with mutation bias, which can skew the likelihood of following a particular trajectory. Strong and persistent directional...
Regulatory utility of physiologically based pharmacokinetic modeling for assessing food impact in bioequivalence studies: A workshop summary report.
Publication Type: Academic Journal
Source(s): CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 May; Vol. 12 (5), pp. 610-618. Date of Electronic Publication: 2023 Jan 16.
Abstract: This workshop report summarizes the presentations and panel discussion related to the use of physiologically based pharmacokinetic (PBPK) modeling approaches for food effect assessment, collected from Session 2 of Day 2 of the workshop titled "Regulato...