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Impact of molecular sequence data completeness on HIV cluster detection and a network science approach to enhance detection.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2022 Nov 10; Vol. 12 (1), pp. 19230. Date of Electronic Publication: 2022 Nov 10.
Abstract: Detection of viral transmission clusters using molecular epidemiology is critical to the response pillar of the Ending the HIV Epidemic initiative. Here, we studied whether inference with an incomplete dataset would influence the accuracy of the recons...
Proposal for the Sungminiaceae fam. nov. (Ralfsiales, Phaeophyceae) for Sungminia gen. nov. with three new species based on molecular and morphological analyses.
Publication Type: Academic Journal
Source(s): Journal of phycology [J Phycol] 2022 Oct; Vol. 58 (5), pp. 719-728. Date of Electronic Publication: 2022 Aug 06.
Abstract: Based on morphological and molecular analyses, five families have been recognized within the crustose brown algal order Ralfsiales. Our morphological and molecular sequence data were used to assess the establishment and phylogenetic relationship of Sun...
Relative performance of Bayesian morphological clock and parsimony methods for phylogenetic reconstructions: Insights from the case of Myomiminae and Dryomyinae glirid rodents.
Publication Type: Academic Journal
Source(s): Cladistics : the international journal of the Willi Hennig Society [Cladistics] 2022 Dec; Vol. 38 (6), pp. 702-710. Date of Electronic Publication: 2022 Aug 31.
Abstract: Extinct organisms provide crucial information about the origin and time of origination of extant groups. The importance of morphological phylogenetics for rigorously dating the tree of life is now widely recognized and has been revitalized by methodolo...
Advancing genomic epidemiology by addressing the bioinformatics bottleneck: Challenges, design principles, and a Swiss example.
Publication Type: Academic Journal
Source(s): Epidemics [Epidemics] 2022 Jun; Vol. 39, pp. 100576. Date of Electronic Publication: 2022 May 14.
Abstract: The SARS-CoV-2 pandemic led to a huge increase in global pathogen genome sequencing efforts, and the resulting data are becoming increasingly important to detect variants of concern, monitor outbreaks, and quantify transmission dynamics. However, this ...
Impacts on International Research Collaborations from DSI/ABS Uncertainty.
Publication Type: Academic Journal
Source(s): Trends in biotechnology [Trends Biotechnol] 2021 May; Vol. 39 (5), pp. 430-433. Date of Electronic Publication: 2020 Nov 23.
Abstract: Digital sequence information (DSI) has no clear definition. Numerous countries define DSI as a nonphysical genetic resources, such as genetic sequence data. Restricting free sharing of DSI is at odds with fundamental science core principles in discipli...
Critical assessment of bioinformatics methods for the characterization of pathological repeat expansions with single-molecule sequencing data.
Publication Type: Academic Journal
Source(s): Briefings in bioinformatics [Brief Bioinform] 2020 Dec 01; Vol. 21 (6), pp. 1971-1986.
Abstract: A number of studies have reported the successful application of single-molecule sequencing technologies to the determination of the size and sequence of pathological expanded microsatellite repeats over the last 5Â years. However, different custom bioin...
ShAn: An easy-to-use tool for interactive and integrated variant annotation.
Publication Type: Academic Journal
Source(s): PloS one [PLoS One] 2020 Jul 07; Vol. 15 (7), pp. e0235669. Date of Electronic Publication: 2020 Jul 07 (Print Publication: 2020).
Abstract: Motivation: Annotation of large amounts of generated sequencing data is a demanding task. Most of the currently available robust annotation tools, like ANNOVAR, are command-line based tools which require a certain degree of programming skills. User-fri...
Computational characterization and analysis of molecular sequence data of Elizabethkingia meningoseptica.
Publication Type: Academic Journal
Source(s): BMC research notes [BMC Res Notes] 2022 Apr 09; Vol. 15 (1), pp. 133. Date of Electronic Publication: 2022 Apr 09.
Abstract: Objective: Elizabethkingia meningoseptica is a multidrug resistance strain which primarily causes meningitis in neonates and immunocompromised patients. Being a nosocomial infection causing agent, less information is available in literature, specifical...
Molecular Mimicry between Betaine Aldehyde Dehydrogenase of Leptospira and Retinal Dehydrogenase 1 of Human Lens: A Potential Trigger for Cataract Formation in Leptospiral Uveitis Patients.
Publication Type: Academic Journal
Source(s): Ocular immunology and inflammation [Ocul Immunol Inflamm] 2021 Apr 03; Vol. 29 (3), pp. 579-586. Date of Electronic Publication: 2019 Nov 20.
Abstract: Purpose : Rapidly progressing cataract is one of the ocular manifestations in leptospiral uveitis patients. We examined whether molecular mimicry between the leptospira antigens and lens proteins exists that could result in cataract in these patients. ...
Seaview Version 5: A Multiplatform Software for Multiple Sequence Alignment, Molecular Phylogenetic Analyses, and Tree Reconciliation.
Publication Type: Academic Journal
Source(s): Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2231, pp. 241-260.
Abstract: We present Seaview version 5, a multiplatform program to perform multiple alignment and phylogenetic tree building from molecular sequence data. Seaview provides network access to sequence databases, alignment with arbitrary algorithm, parsimony, dista...