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The treatment of symptomatic fat necrosis: A review and introduction of a new treatment algorithm.
Publication Type: Academic Journal
Source(s): Journal of plastic, reconstructive & aesthetic surgery : JPRAS [J Plast Reconstr Aesthet Surg] 2023 Feb; Vol. 77, pp. 87-93. Date of Electronic Publication: 2022 Nov 24.
Abstract: Objective: Fat necrosis (FN) is a well-known complication in plastic surgery. Excision of symptomatic FN has been the gold standard, but it often results in contour irregularities that require subsequent treatment. Different alternative surgical and no...
Targeting Tumor Necrosis Factor Receptor 1 with Selected Aptamers for Anti-Inflammatory Activity.
Publication Type: Academic Journal
Source(s): ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2023 Mar 08; Vol. 15 (9), pp. 11599-11608. Date of Electronic Publication: 2023 Feb 22.
Abstract: Tumor necrosis factor-α (TNFα) inhibitors are widely used in treating autoimmune diseases like rheumatoid arthritis (RA). These inhibitors can presumably alleviate RA symptoms by blocking TNFα-TNF receptor 1 (TNFR1)-mediated pro-inflammatory signaling ...
Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-α triggers tumorigenic inflammation in neuroblastoma.
Publication Type: Academic Journal
Source(s): Journal for immunotherapy of cancer [J Immunother Cancer] 2023 Mar; Vol. 11 (3).
Abstract: Background: Tumor progression and resistance to therapy in children with neuroblastoma (NB), a common childhood cancer, are often associated with infiltration of monocytes and macrophages that produce inflammatory cytokines. However, the mechanism by w...
Loss of tumor necrosis factor (TNF)-receptor 1 and TNF-receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus.
Publication Type: Academic Journal
Source(s): The Journal of comparative neurology [J Comp Neurol] 2023 Feb; Vol. 531 (2), pp. 281-293. Date of Electronic Publication: 2022 Oct 11.
Abstract: The cytokine tumor necrosis factor (TNF) is involved in the regulation of physiological and pathophysiological processes in the central nervous system. In previous work, we showed that mice lacking constitutive levels of TNF exhibit a reduction in spin...
Risk of Multiple Sclerosis Among Users of Antitumor Necrosis Factor α in 4 Canadian Provinces: A Population-Based Study.
Publication Type: Academic Journal
Source(s): Neurology [Neurology] 2023 Feb 07; Vol. 100 (6), pp. e558-e567. Date of Electronic Publication: 2022 Oct 28.
Abstract: Background and Objectives: Antitumor necrosis factor α (TNFα) agents are a class of biologic drugs used for the treatment of several immune-mediated conditions. An increased risk of multiple sclerosis (MS) with their use has been suggested, but studies...
MiR-29c Inhibits TNF-α-Induced ROS Production and Apoptosis in Mouse Hippocampal HT22 Cell Line.
Publication Type: Academic Journal
Source(s): Neurochemical research [Neurochem Res] 2023 Feb; Vol. 48 (2), pp. 519-536. Date of Electronic Publication: 2022 Oct 30.
Abstract: Recent reports have suggested that abnormal miR-29c expression in hippocampus have been implicated in the pathophysiology of some neurodegenerative and neuropsychiatric diseases. However, the underlying effect of miR-29c in regulating hippocampal neuro...
Bistability regulates TNFR2-mediated survival and death of T-regulatory cells.
Publication Type: Academic Journal
Source(s): Journal of biological physics [J Biol Phys] 2023 Mar; Vol. 49 (1), pp. 95-119. Date of Electronic Publication: 2023 Feb 13.
Abstract: A subgroup of T cells called T-regulatory cells (Tregs) regulates the body's immune responses to maintain homeostasis and self-tolerance. Tregs are crucial for preventing illnesses like cancer and autoimmunity. However, contrasting patterns of Treg fre...
Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF.
Publication Type: Academic Journal
Source(s): Nature immunology [Nat Immunol] 2023 Mar; Vol. 24 (3), pp. 474-486. Date of Electronic Publication: 2023 Jan 26.
Abstract: The cross-talk between thymocytes and thymic stromal cells is fundamental for T cell development. In humans, intrathymic development of dendritic cells (DCs) is evident but its physiological significance is unknown. Here we showed that DC-biased precur...
The prohibitin complex regulates macrophage fatty acid composition, plasma membrane packing, and lipid raft-mediated inflammatory signaling.
Publication Type: Academic Journal
Source(s): Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2023 Mar; Vol. 190, pp. 102540. Date of Electronic Publication: 2023 Jan 19.
Abstract: Prohibitins (PHB1 and PHB2) are ubiquitously expressed proteins which play critical roles in multiple biological processes, and together form the ring-like PHB complex found in phospholipid-rich cellular compartments including lipid rafts. Recent studi...