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Loss of brainstem white matter predicts onset and motor neuron symptoms in C9orf72 expansion carriers: a GENFI study.
Publication Type: Academic Journal
Source(s): Journal of neurology [J Neurol] 2023 Mar; Vol. 270 (3), pp. 1573-1586. Date of Electronic Publication: 2022 Nov 29.
Abstract: Background and Objectives: The C9orf72 expansion is the most common genetic cause of frontotemporal dementia (FTD) and/or motor neuron disease (MND). Corticospinal degeneration has been described in post-mortem neuropathological studies in these patien...
M1/precuneus ratio as a surrogate marker of upper motor neuron sign in ALS.
Publication Type: Academic Journal
Source(s): Journal of the neurological sciences [J Neurol Sci] 2023 Feb 15; Vol. 445, pp. 120548. Date of Electronic Publication: 2023 Jan 07.
Abstract: Objective: To investigate whether primary motor cortex (M1) volume measured with an automated approach in MRI reflects upper motor neuron dysfunction and whether it can serve as a potential diagnostic and/or disease-tracking biomarker for amyotrophic l...
SMN Deficiency Destabilizes ABCA1 Expression in Human Fibroblasts: Novel Insights in Pathophysiology of Spinal Muscular Atrophy.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Feb 02; Vol. 24 (3). Date of Electronic Publication: 2023 Feb 02.
Abstract: The deficiency of survival motor neuron protein (SMN) causes spinal muscular atrophy (SMA), a rare neuromuscular disease that affects different organs. SMN is a key player in RNA metabolism regulation. An intriguing aspect of SMN function is its relati...
Non-nociceptive and nociceptive-like trigeminal Aβ-afferent neurons of rats: Distinct electrophysiological properties, mechanical and chemical sensitivity.
Publication Type: Academic Journal
Source(s): Molecular pain [Mol Pain] 2023 Jan-Dec; Vol. 19, pp. 17448069221148958.
Abstract: The role of Aβ-afferents in somatosensory function is often oversimplified as low threshold mechanoreceptors (LTMRs) with large omission of Aβ-afferent involvement in nociception. Recently, we have characterized Aβ-afferent neurons which have large dia...
Screening and prenatal diagnosis of survival motor neuron gene deletion in pregnant women in Zhaoqing city, Guangdong Province.
Publication Type: Academic Journal
Source(s): BMC medical genomics [BMC Med Genomics] 2023 Mar 01; Vol. 16 (1), pp. 39. Date of Electronic Publication: 2023 Mar 01.
Abstract: Objective: A total of 5,200 pregnant women in Zhaoqing city, Guangdong Province, were screened to identify spinal muscular atrophy (SMA) mutation carriers to guide the prevention of SMA and prevent the birth of children with SMA.Methods: Exons 7 and 8 ...
Stability of olfactory behavior syndromes in the Drosophila larva.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2023 Feb 10; Vol. 13 (1), pp. 2398. Date of Electronic Publication: 2023 Feb 10.
Abstract: Individuals of many animal populations exhibit idiosyncratic behaviors. One measure of idiosyncratic behavior is a behavior syndrome, defined as the stability of one or more behavior traits in an individual across different situations. While behavior s...
Diabetes mellitus differently affects electrical membrane properties of vagal afferent neurons of rats.
Publication Type: Academic Journal
Source(s): Physiological reports [Physiol Rep] 2023 Feb; Vol. 11 (4), pp. e15605.
Abstract: To study whether diabetes mellitus (DM) would cause electrophysiological alterations in nodose ganglion (NG) neurons, we used patch clamp and intracellular recording for voltage and current clamp configuration, respectively, on cell bodies of NG from r...
Adult motor neuron disease death rates in Finland 1998-2019.
Publication Type: Editorial & Opinion
Source(s): Journal of neurology [J Neurol] 2023 Feb; Vol. 270 (2), pp. 1147-1149. Date of Electronic Publication: 2022 Oct 03.
Modulation of spinal circuits following phase-dependent electrical stimulation of afferent pathways.
Publication Type: Academic Journal
Source(s): Journal of neural engineering [J Neural Eng] 2023 Jan 27; Vol. 20 (1). Date of Electronic Publication: 2023 Jan 27.
Abstract: Objective. Peripheral electrical stimulation (PES) of afferent pathways is a tool commonly used to induce neural adaptations in some neural disorders such as pathological tremor or stroke. However, the neuromodulatory effects of stimulation interventio...
Effect of high-frequency membrane potential alternation between depolarization and hyperpolarization on dorsal root ganglion neurons of rats.
Publication Type: Academic Journal
Source(s): Physiological reports [Physiol Rep] 2023 Jan; Vol. 11 (2), pp. e15582.
Abstract: The purpose of this study was to determine how sensory neurons respond to high-frequency membrane potential alternation between depolarization and hyperpolarization. Membrane currents were recorded from dissociated dorsal root ganglion (DRG) neurons of...