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USP14 regulates heme metabolism and ovarian cancer invasion through BACH1 deubiquitination and stabilization.
Publication Type: Academic Journal
Source(s): Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Jul 30; Vol. 667, pp. 186-193. Date of Electronic Publication: 2023 May 12.
Abstract: The deubiquitinating enzyme USP14 has been established as a crucial regulator in various diseases, including tumors, neurodegenerative diseases, and metabolic diseases, through its ability to stabilize its substrate proteins. Our group has utilized pro...
Evaluation of Bach1 mRNA expression in patients with chronic kidney disease: A preliminary study.
Publication Type: Academic Journal
Source(s): Hemodialysis international. International Symposium on Home Hemodialysis [Hemodial Int] 2023 Jul; Vol. 27 (3), pp. 301-307. Date of Electronic Publication: 2023 Apr 03.
Abstract: Introduction: BTB and CNC homology 1 (Bach1) is a protein that antagonizes some actions of nuclear factor erythroid 2-related factor-2 (Nrf2), the master regulator of cytoprotective responses. Bach1 binds to genomic DNA and inhibits the synthesis of an...
Fibroblast growth factor 10 alleviates acute lung injury by inhibiting excessive autophagy via Nrf2.
Publication Type: Academic Journal
Source(s): The Journal of endocrinology [J Endocrinol] 2023 Aug 17; Vol. 259 (1). Date of Electronic Publication: 2023 Aug 17 (Print Publication: 2023).
Abstract: Acute lung injury (ALI) is associated with an increased incidence of respiratory diseases, which are devastating clinical disorders with high global mortality and morbidity. Evidence confirms that fibroblast growth factors (FGFs) play key roles in medi...
Dietary Polyphenols Remodel DNA Methylation Patterns of NRF2 in Chronic Disease.
Publication Type: Academic Journal
Source(s): Nutrients [Nutrients] 2023 Jul 27; Vol. 15 (15). Date of Electronic Publication: 2023 Jul 27.
Abstract: The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor crucial in regulating cellular homeostasis and apoptosis. The NRF2 gene has been implicated in various biological activities, including antioxidant, anti-inflammatory, and...
The anti-inflammatory and anti-oxidative effect of a classical hypnotic bromovalerylurea mediated by the activation of NRF2.
Publication Type: Academic Journal
Source(s): Journal of biochemistry [J Biochem] 2023 Jul 31; Vol. 174 (2), pp. 131-142.
Abstract: The Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (KEAP1-NRF2) system plays a central role in redox homeostasis and inflammation control. Oxidative stress or electrophilic compounds promote NRF2 stabilization and trans...
Mangiferin Protects DNase 2 Abundance via Nrf2 Activation to Prevent Cytosolic mtDNA Accumulation during Liver Injury.
Publication Type: Academic Journal
Source(s): Molecular nutrition & food research [Mol Nutr Food Res] 2023 Jul; Vol. 67 (14), pp. e2200885. Date of Electronic Publication: 2023 May 25.
Abstract: Scope: Mitochondrial DNA (mtDNA) released into the cytosol serves as a member of damage-associated molecular patterns to initiate inflammatory responses. Mangiferin is a xanthonoid derivative, usually isolated from plants including mangoes and iris ung...
Age and oxidative stress regulate Nrf2 homeostasis in human articular chondrocytes.
Publication Type: Academic Journal
Source(s): Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2023 Sep; Vol. 31 (9), pp. 1214-1223. Date of Electronic Publication: 2023 May 07.
Abstract: Objective: The purpose of this study was to investigate the effect of age and oxidative stress on regulation of nuclear factor erythroid-2-related factor 2 (Nrf2) in young, old, and osteoarthritic (OA) human articular chondrocytes.Design: Levels of Nrf...
Cardamonin targets KEAP1/NRF2 signaling for protection against atherosclerosis.
Publication Type: Academic Journal
Source(s): Food & function [Food Funct] 2023 May 22; Vol. 14 (10), pp. 4905-4920. Date of Electronic Publication: 2023 May 22.
Abstract: Atherosclerosis (AS)-induced cardiovascular disease is a leading cause of death worldwide. To date, there is still a lack of effective approaches for AS intervention. Cardamonin (CAD) is a bioactive food component, but its effect on AS is unknown. In t...
Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly.
Publication Type: Academic Journal
Source(s): Free radical biology & medicine [Free Radic Biol Med] 2023 Aug 01; Vol. 204, pp. 215-225. Date of Electronic Publication: 2023 May 06.
Abstract: KEAP1 promotes the ubiquitin-dependent degradation of NRF2 by assembling into a CUL3-dependent ubiquitin ligase complex. Oxidative and electrophilic stress inhibit KEAP1 allowing NRF2 to accumulate for the transactivation of stress response genes. To d...
The thioredoxin expression of Cristaria plicata is regulated by Nrf2/ARE pathway under microcystin stimulation.
Publication Type: Academic Journal
Source(s): International journal of biological macromolecules [Int J Biol Macromol] 2023 Jul 01; Vol. 242 (Pt 1), pp. 124509. Date of Electronic Publication: 2023 Apr 19.
Abstract: Thioredoxin plays an important role in inhibiting apoptosis and protecting cells from oxidative stress. This study was aimed to clarify how the expression of Trx from Cristaria plicata is regulated by Nrf2/ARE pathway. The expression of CpTrx mRNA was ...