scroll to top
Your source for trusted research content

EBSCO Auth Banner

Let's find your institution. Click here.

Advanced Search Results For "NF-kappa B"

Filter
1 - 10 of 108,820 results for
 "NF-kappa B"
Your filters
  • Filter by:
  • Reset filters

    • Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency.

    Publication Type: Academic Journal

    Source(s): Nature [Nature] 2023 Nov; Vol. 623 (7988), pp. 803-813. Date of Electronic Publication: 2023 Nov 08.

    Abstract: Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs) 1,2 , conferring a predisposition to life-threatening COVID-19 pneumonia ...

    TRIM55 promotes noncanonical NF-κB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing.

    Publication Type: Academic Journal

    Source(s): Science signaling [Sci Signal] 2023 Oct 10; Vol. 16 (806), pp. eabn5410. Date of Electronic Publication: 2023 Oct 10.

    Authors:

    Abstract: The ubiquitination-dependent processing of NF-κB2 (also known as p100) is a critical step in the activation of the noncanonical NF-κB pathway. We investigated the molecular mechanisms regulating this process and showed that TRIM55 was the E3 ubiquitin ...

    NF-κB2 defects in autoimmunity.

    Publication Type: Academic Journal

    Source(s): Nature immunology [Nat Immunol] 2023 Dec; Vol. 24 (12), pp. 1965.

    Authors:

    Inflammation and Neutrophil Oxidative Burst in a Family with NFKB1 p.R157X LOF and Sterile Necrotizing Fasciitis.

    Publication Type: Academic Journal

    Source(s): Journal of clinical immunology [J Clin Immunol] 2023 Jul; Vol. 43 (5), pp. 1007-1018. Date of Electronic Publication: 2023 Mar 09.

    Abstract: Loss-of-function (LOF) mutations in NFKB1, coding for p105, may cause common variable immunodeficiency due to dysregulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κΒ) pathway. Monoallelic LOF variants of NFKB1 can predisp...

    NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression.

    Publication Type: Academic Journal

    Source(s): Communications biology [Commun Biol] 2023 Apr 22; Vol. 6 (1), pp. 445. Date of Electronic Publication: 2023 Apr 22.

    Authors:

    Abstract: Gliomas are highly invasive and chemoresistant cancers, making them challenging to treat. Chronic inflammation is a key driver of glioma progression as it promotes aberrant activation of inflammatory pathways such as NF-κB signalling, which drives canc...

    Innate Immune Zonation in the Liver: NF-κB (p50) Activation and C-Reactive Protein Expression in Response to Endotoxemia Are Zone Specific.

    Publication Type: Academic Journal

    Source(s): Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2023 May 01; Vol. 210 (9), pp. 1372-1385.

    Abstract: Hepatic innate immune function plays an important role in the pathogenesis of many diseases. Importantly, a growing body of literature has firmly established the spatial heterogeneity of hepatocyte metabolic function; however, whether innate immune fun...

    Rabdosichuanin C inhibits productions of pro-inflammatory mediators regulated by NF-κB signaling in LPS-stimulated RAW264.7 cells.

    Publication Type: Academic Journal

    Source(s): Journal of cellular biochemistry [J Cell Biochem] 2023 Nov; Vol. 124 (11), pp. 1667-1684. Date of Electronic Publication: 2023 Oct 18.

    Abstract: Chronic pharyngitis (CP) is an inflammatory disease of the pharyngeal mucosa and its lymphatic tissues that is difficult to treat clinically. However, research on the exact therapeutic agents and molecular mechanisms of CP is still unclear. In this stu...

    Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome.

    Publication Type: Academic Journal

    Source(s): The EMBO journal [EMBO J] 2023 Oct 16; Vol. 42 (20), pp. e115307. Date of Electronic Publication: 2023 Sep 11.

    Abstract: Removal of polyploid cells is essential to preventing cancer and restricting tumor growth. A new study published in The EMBO Journal shows assembly of the NEMO-PIDDosome on extra centrioles. Activation of this protein complex leads to NF-κB activation ...

    Novel c-Myc G4 stabilizer EP12 promotes myeloma cytotoxicity by disturbing NF-κB signaling.

    Publication Type: Academic Journal

    Source(s): Experimental cell research [Exp Cell Res] 2023 Oct 01; Vol. 431 (1), pp. 113759. Date of Electronic Publication: 2023 Aug 23.

    Authors:

    Abstract: Multiple myeloma (MM) is a B-cell malignancy characterized by the excessive proliferation of bone marrow plasma cells and the production of abnormal immunoglobulins. Despite advances in therapeutic strategies, it remains an incurable disease. Recently,...

    How do nuclear factor kappa B (NF-κB)1 and NF-κB2 defects lead to the incidence of clinical and immunological manifestations of inborn errors of immunity?

    Publication Type: Academic Journal

    Source(s): Expert review of clinical immunology [Expert Rev Clin Immunol] 2023 Mar; Vol. 19 (3), pp. 329-339. Date of Electronic Publication: 2023 Feb 09.

    Abstract: Introduction: Genetic defects affect the manner of the immune system's development, activation, and function. Nuclear factor-kappa B subunit 1 (NF-κB1) and NF-κB2 are involved in different biological processes, and deficiency in these transcription fac...

    sponsored