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Association Between ABCG2, ABCB1, ABCC2 Efflux Transporter Single-Nucleotide Variants and Irinotecan Adverse Effects in Patients With Colorectal Cancer: A Real-Life Study.
Publication Type: Academic Journal
Source(s): Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2023 Mar; Vol. 113 (3), pp. 704-711. Date of Electronic Publication: 2023 Jan 06.
Abstract: Among patients treated with irinotecan, homozygous carriers of the UGT1A1*28 allele are at increased risk for neutropenia, but UGT1A1 genotype alone does not account for irinotecan-induced toxicity. Our aim was to study the association between single-n...
Quantitative proteomic landscapes of primary and recurrent glioblastoma reveal a protumorigeneic role for FBXO2-dependent glioma-microenvironment interactions.
Publication Type: Academic Journal
Source(s): Neuro-oncology [Neuro Oncol] 2023 Feb 14; Vol. 25 (2), pp. 290-302.
Abstract: Background: Recent efforts have described the evolution of glioblastoma from initial diagnosis to post-treatment recurrence on a genomic and transcriptomic level. However, the evolution of the proteomic landscape is largely unknown.Methods: Sequential ...
CARMA3: A potential therapeutic target in non-cancer diseases.
Publication Type: Academic Journal
Source(s): Frontiers in immunology [Front Immunol] 2022 Dec 22; Vol. 13, pp. 1057980. Date of Electronic Publication: 2022 Dec 22 (Print Publication: 2022).
Abstract: Caspase recruitment domain and membrane-associated guanylate kinase-like protein 3 (CARMA3) is a scaffold protein widely expressed in non-hematopoietic cells. It is encoded by the caspase recruitment domain protein 10 ( CARD10 ) gene. CARMA3 can form a...
Novel biomarkers predict prognosis and drug-induced neuroendocrine differentiation in patients with prostate cancer.
Publication Type: Academic Journal
Source(s): Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Jan 05; Vol. 13, pp. 1005916. Date of Electronic Publication: 2023 Jan 05 (Print Publication: 2022).
Abstract: Background: A huge focus is being placed on the development of novel signatures in the form of new combinatorial regimens to distinguish the neuroendocrine (NE) characteristics from castration resistant prostate cancer (CRPC) timely and accurately, as ...
Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK.
Publication Type: Academic Journal
Source(s): Cancer medicine [Cancer Med] 2023 Jan; Vol. 12 (1), pp. 488-499. Date of Electronic Publication: 2022 Jun 06.
Abstract: Background: The AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, with deregulation leading to cancer and other diseases. However, how this pathway is dysregulated in cancer has not been well clarified.Methods: Using a t...
Alternative splicing in CEP290 mutant cats results in a milder phenotype than LCA CEP290 patients.
Publication Type: Academic Journal
Source(s): Veterinary ophthalmology [Vet Ophthalmol] 2023 Jan; Vol. 26 (1), pp. 4-11. Date of Electronic Publication: 2022 Dec 09.
Abstract: Purpose: The rdAc cat has an intronic mutation in the centrosomal 290 kDa (CEP290) gene resulting in a frameshift and a premature stop codon (c.6960 + 9 T > G, p.Ile2321AlafsTer3) predicted to truncate the protein by 157 amino acids. CEP290 mutations i...
Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma.
Publication Type: Academic Journal
Source(s): Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2022 Dec; Vol. 45 (6), pp. 1451-1465. Date of Electronic Publication: 2022 Oct 26.
Abstract: Purpose: Glioblastoma (GBM) is the most malignant subtype of astrocytic tumors with the worst prognosis in all its progressive forms. Breast cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene that controls malignancy in multiple tum...
The effects of endosulfan on cell migration and invasion in prostate cancer cells via the KCNQ1OT1/miR-137-3p/PTP4A3 axis.
Publication Type: Academic Journal
Source(s): The Science of the total environment [Sci Total Environ] 2022 Nov 01; Vol. 845, pp. 157252. Date of Electronic Publication: 2022 Jul 08.
Abstract: Endosulfan belongs to persistent organic pollutants (POPs), closely related to an increased risk of prostate cancer (PCa). The existing evidence shows that lncRNAs compete with miRNAs for binding sites and contribute to the onset and progression of hum...
NUT carcinoma of the mandible in a child: case report and systematic review.
Publication Type: Academic Journal
Source(s): International journal of oral and maxillofacial surgery [Int J Oral Maxillofac Surg] 2023 Mar; Vol. 52 (3), pp. 304-312. Date of Electronic Publication: 2022 Jul 19.
Abstract: Nuclear protein of the testis (NUT) carcinoma is a rare, undifferentiated carcinoma that is characterized by NUTM1 gene rearrangements. Patients with NUT carcinoma have an overall survival of approximately 5% at 5 years despite a multimodal treatment a...
Next-Generation Sequencing Reveals a New Class of Melanocytic Neoplasms With Hybrid Genomic Features of PEM Including Protein Kinase R 1 Alpha Gene Inactivation and Spitz Tumor-Defining Protein Kinase Fusions.
Publication Type: Academic Journal
Source(s): The American Journal of dermatopathology [Am J Dermatopathol] 2022 Aug 01; Vol. 44 (8), pp. 568-574. Date of Electronic Publication: 2022 May 04.
Abstract: Background: Pigmented epithelioid melanocytoma (PEM) is a subtype of melanocytic tumor with frequent involvement of the sentinel lymph node but rare distant metastasis. Rendering a diagnosis and prognosis based on histology can be challenging. Recent g...