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Advanced Search Results For "Neoplasm Proteins metabolism"

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 "Neoplasm Proteins metabolism"
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CARMA3: A potential therapeutic target in non-cancer diseases.

Publication Type: Academic Journal

Source(s): Frontiers in immunology [Front Immunol] 2022 Dec 22; Vol. 13, pp. 1057980. Date of Electronic Publication: 2022 Dec 22 (Print Publication: 2022).

Authors:

Abstract: Caspase recruitment domain and membrane-associated guanylate kinase-like protein 3 (CARMA3) is a scaffold protein widely expressed in non-hematopoietic cells. It is encoded by the caspase recruitment domain protein 10 ( CARD10 ) gene. CARMA3 can form a...

Transporter-mediated Natural Product-Drug Interactions.

Publication Type: Academic Journal

Source(s): Planta medica [Planta Med] 2023 Feb; Vol. 89 (2), pp. 119-133. Date of Electronic Publication: 2022 Mar 18.

Authors:

Abstract: The increasing use of natural products in clinical practice has raised great concerns about the potential natural product-drug interactions (NDIs). Drug transporters mediate the transmembrane passage of a broad range of drugs, and thus are important de...

Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis.

Publication Type: Academic Journal

Source(s): Theranostics [Theranostics] 2022 Jul 18; Vol. 12 (12), pp. 5574-5595. Date of Electronic Publication: 2022 Jul 18 (Print Publication: 2022).

Abstract: The survival rate of colorectal cancer patients is adversely affected by the selection of tumors resistant to conventional anti-cancer drugs such as 5-fluorouracil (5FU). Although there is mounting evidence that commensal gut microbiota is essential fo...

Placental and plasma early predictive biomarkers for gestational diabetes mellitus.

Publication Type: Academic Journal

Source(s): Proteomics. Clinical applications [Proteomics Clin Appl] 2022 Jul; Vol. 16 (4), pp. e2200001. Date of Electronic Publication: 2022 Apr 14.

Authors:

Abstract: Purpose: Gestational diabetes mellitus (GDM) is a common disease that can give rise to adverse obstetric outcomes. For successful early intervention, more studies on novel predictive biomarkers for GDM are required.Experimental Design: The protein expr...

Prandial state and biological sex modulate clinically relevant efflux transporters to different extents in Wistar and Sprague Dawley rats.

Publication Type: Academic Journal

Source(s): Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Apr; Vol. 160, pp. 114329. Date of Electronic Publication: 2023 Jan 31.

Abstract: P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug resistance-associated protein 2 (MRP2) are clinically relevant efflux transporters implicated in the oral absorption of many food and drug substrates. Here, we hypothesised t...

Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR α -Dependent Mechanism in Human Brain Endothelial Cells.

Publication Type: Academic Journal

Source(s): Molecular pharmacology [Mol Pharmacol] 2023 Mar; Vol. 103 (3), pp. 145-157. Date of Electronic Publication: 2022 Nov 22.

Abstract: Despite the progress made in the development of new antiepileptic drugs (AEDs), poor response to them is a rising concern in epilepsy treatment. Of several hypotheses explaining AED treatment failure, the most promising theory is the overexpression of ...

Assessment of the role of nucleoside transporters, P-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in the placental transport of entecavir using in vitro, ex vivo, and in situ methods.

Publication Type: Academic Journal

Source(s): Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2023 Mar 15; Vol. 463, pp. 116427. Date of Electronic Publication: 2023 Feb 16.

Abstract: The nucleoside analog entecavir (ETV) is a first-line pharmacotherapy for chronic hepatitis B in adult and pediatric patients. However, due to insufficient data on placental transfer and its effects on pregnancy, ETV administration is not recommended f...

Sublytic gasdermin-D pores captured in atomistic molecular simulations.

Publication Type: Academic Journal

Source(s): ELife [Elife] 2022 Nov 14; Vol. 11. Date of Electronic Publication: 2022 Nov 14.

Abstract: Gasdermin-D (GSDMD) is the ultimate effector of pyroptosis, a form of programmed cell death associated with pathogen invasion and inflammation. After proteolytic cleavage by caspases, the GSDMD N-terminal domain (GSDMD NT ) assembles on the inner leafl...

Diagnostic Efficacy of PSMA and PSCA mRNAs Combined to PSA in Prostate Cancer Patients.

Publication Type: Academic Journal

Source(s): Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2023 Jan 01; Vol. 24 (1), pp. 223-229. Date of Electronic Publication: 2023 Jan 01.

Abstract: Background: Serum Prostate-specific antigen (PSA) has been used for screening and diagnosis of prostate cancer (PCa) but it is burdened by its low accuracy, creating a need for reliable diagnostic markers. Despite prostate-specific membrane antigen (PS...

Maternal and Fetal Exposure to (-)-Δ 9 -tetrahydrocannabinol and Its Major Metabolites in Pregnant Mice Is Differentially Impacted by P-glycoprotein and Breast Cancer Resistance Protein.

Publication Type: Academic Journal

Source(s): Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2023 Mar; Vol. 51 (3), pp. 269-275. Date of Electronic Publication: 2022 Nov 29.

Abstract: (-)-Δ 9 -tetrahydrocannabinol (THC) is the primary pharmacological active constituent of cannabis. 11-hydroxy-THC (11-OH-THC) and 11- nor -9-carboxy-THC (THC-COOH) are respectively the active and nonactive circulating metabolites of THC in humans. Whil...

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