Advanced Search Results For "Neuroprotective Agents administration & dosage"
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Why ketamine.
Publication Type: Academic Journal
Source(s): Epilepsy & behavior : E&B [Epilepsy Behav] 2023 Apr; Vol. 141, pp. 109066. Date of Electronic Publication: 2023 Jan 04.
Abstract: We present the rationale for testing ketamine as an add-on therapy for treating benzodiazepine refractory (established) status epilepticus. In animal studies, ketamine terminates benzodiazepine refractory status epilepticus by interfering with the path...
Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns.
Publication Type: Academic Journal
Source(s): The New England journal of medicine [N Engl J Med] 2022 Jul 14; Vol. 387 (2), pp. 148-159.
Abstract: Background: Neonatal hypoxic-ischemic encephalopathy is an important cause of death as well as long-term disability in survivors. Erythropoietin has been hypothesized to have neuroprotective effects in infants with hypoxic-ischemic encephalopathy, but ...
Early administration of MPC-n(IVIg) selectively accumulates in ischemic areas to protect inflammation-induced brain damage from ischemic stroke.
Publication Type: Academic Journal
Source(s): Theranostics [Theranostics] 2021 Jul 13; Vol. 11 (17), pp. 8197-8217. Date of Electronic Publication: 2021 Jul 13 (Print Publication: 2021).
Abstract: Ischemic stroke is an acute and severe neurological disease, which leads to disability and death. Immunomodulatory therapies exert multiple remarkable protective effects during ischemic stroke. However, patients suffering from ischemic stroke do not be...
Asiatic acid attenuates aluminium chloride-induced behavioral changes, neuronal loss and astrocyte activation in rats.
Publication Type: Academic Journal
Source(s): Metabolic brain disease [Metab Brain Dis] 2022 Aug; Vol. 37 (6), pp. 1773-1785. Date of Electronic Publication: 2022 May 13.
Abstract: Aluminium (Al) is a potent neurotoxic metal known to cause neurodegeneration. Al exposure causes oxidative stress by accumulation of reactive oxygen species, followed by the activation of neuronal cell death in the brain. Asiatic acid (AA), the major b...
Neuroprotective effects of curcumin-loaded nanophytosome on ketamine-induced schizophrenia-like behaviors and oxidative damage in male mice.
Publication Type: Academic Journal
Source(s): Neuroscience letters [Neurosci Lett] 2021 Nov 20; Vol. 765, pp. 136249. Date of Electronic Publication: 2021 Sep 15.
Abstract: Curcumin as an antioxidant natural herb has shown numerous pharmacological effects. However, the poor bioavailability of curcumin is a significant pharmacological barrier for its antioxidant activities. The present study was conducted to develop curcum...
Preserving Brain LPC-DHA by Plasma Supplementation Attenuates Brain Injury after Cardiac Arrest.
Publication Type: Academic Journal
Source(s): Annals of neurology [Ann Neurol] 2022 Mar; Vol. 91 (3), pp. 389-403. Date of Electronic Publication: 2022 Jan 24.
Abstract: Objective: Cardiac arrest (CA) is a major health burden with brain damage being a significant contributor to mortality. We found lysophosphatidylcholine (LPC), including a species containing docosahexaenoic acid (LPC-DHA), was significantly decreased i...
Inflammatory Response to Spinal Cord Injury and Its Treatment.
Publication Type: Academic Journal
Source(s): World neurosurgery [World Neurosurg] 2021 Nov; Vol. 155, pp. 19-31. Date of Electronic Publication: 2021 Aug 08.
Abstract: Spinal cord injury (SCI), as one of the intractable diseases in clinical medicine, affects thousands of human beings, and the pathologic changes after injury have been a hot spot for exploration in clinical medicine. With the development of new treatme...
The Mechanisms Underlying the Protective Action of Selenium Nanoparticles against Ischemia/Reoxygenation Are Mediated by the Activation of the Ca 2+ Signaling System of Astrocytes and Reactive Astrogliosis.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2021 Nov 26; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 26.
Abstract: In recent years, much attention has been paid to the study of the therapeutic effect of the microelement selenium, its compounds, especially selenium nanoparticles, with a large number of works devoted to their anticancer effects. Studies proving the n...
The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment.
Publication Type: Academic Journal
Source(s): Journal of pharmacological sciences [J Pharmacol Sci] 2022 Jan; Vol. 148 (1), pp. 162-171. Date of Electronic Publication: 2021 Nov 12.
Abstract: Alzheimer's disease (AD) is characterized by progressive cognitive decline, and the number of affected individuals has increased worldwide. However, there are no effective treatments for AD. Therefore, it is important to prevent the onset of dementia. ...
Nanoemulsion Improves the Neuroprotective Effects of Curcumin in an Experimental Model of Parkinson's Disease.
Publication Type: Academic Journal
Source(s): Neurotoxicity research [Neurotox Res] 2021 Jun; Vol. 39 (3), pp. 787-799. Date of Electronic Publication: 2021 Apr 16.
Abstract: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. Recent studies have shown that curcumin (CUR) has neuroprotective effects in PD experimental models. However, its efficacy is limited due to low water solubili...