Advanced Search Results For "Oxidative Stress drug effects"
Your filters
Rosmarinic acid mitigates chlorpyrifos-induced oxidative stress, inflammation, and kidney injury in rats by modulating SIRT1 and Nrf2/HO-1 signaling.
Publication Type: Academic Journal
Source(s): Life sciences [Life Sci] 2023 Jan 15; Vol. 313, pp. 121281. Date of Electronic Publication: 2022 Dec 12.
Abstract: Chlorpyrifos (CPF) is a widely used broad-spectrum pesticide with multi-organ toxic effects. Oxidative stress was found to play a role in the deleterious effects of CPF, including nephrotoxicity. This study investigated the protective effect of the ant...
Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition.
Publication Type: Academic Journal
Source(s): Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2023 Jan 01; Vol. 249, pp. 114364. Date of Electronic Publication: 2022 Dec 09.
Abstract: Ferric citrate (FC) has been used as an iron fortifier and nutritional supplement, which is reported to induce colitis in rats, however the underlying mechanism remains to be elucidated. We performed a 16-week study of FC in male healthy C57BL/6 mice (...
Molecular Mechanisms of Oxidative Stress Relief by CAPE in ARPE-19 Cells.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Feb 10; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 10.
Abstract: Caffeic acid phenylethyl ester (CAPE) is an antioxidative agent originally derived from propolis. Oxidative stress is a significant pathogenic factor in most retinal diseases. Our previous study revealed that CAPE suppresses mitochondrial ROS productio...
Advances and challenges in therapeutic targeting of NRF2.
Publication Type: Academic Journal
Source(s): Trends in pharmacological sciences [Trends Pharmacol Sci] 2023 Mar; Vol. 44 (3), pp. 137-149. Date of Electronic Publication: 2023 Jan 09.
Abstract: Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation, and metabolic imbalances. These processes underpin many chronic pa...
Ameliorative effect of Lactobacillus plantarum Lp2 against cyclophosphamide-induced liver injury in mice.
Publication Type: Academic Journal
Source(s): Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2022 Nov; Vol. 169, pp. 113433. Date of Electronic Publication: 2022 Sep 16.
Abstract: Cyclophosphamide (CTX) is a widely used anticancer drug that can cause liver injury, but there is no effective treatment available at present. The antioxidant properties of Lactobacillus plantarum Lp2 in vitro and its effect on CTX-induced liver injury...
RNA methylation and cellular response to oxidative stress-promoting anticancer agents.
Publication Type: Academic Journal
Source(s): Cell cycle (Georgetown, Tex.) [Cell Cycle] 2023 Apr; Vol. 22 (8), pp. 870-905. Date of Electronic Publication: 2023 Jan 17.
Abstract: Disruption of the complex network that regulates redox homeostasis often underlies resistant phenotypes, which hinder effective and long-lasting cancer eradication. In addition, the RNA methylome-dependent control of gene expression also critically aff...
The protective effect of carvacrol on bevacizumab-related skin injury in rats: a biochemical and histopathological evaluation.
Publication Type: Academic Journal
Source(s): Cutaneous and ocular toxicology [Cutan Ocul Toxicol] 2022 Dec; Vol. 41 (4), pp. 285-290. Date of Electronic Publication: 2022 Sep 21.
Abstract: Purpose: Bevacizumab is a recombinant humanized monoclonal antibody that specifically binds to vascular endothelial growth factor (VEGF). Cutaneous side effects of bevacizumab are seen with substantial frequency and may require the interruption of the ...
[Effects of different low-dose of insulin glargine on antioxidation of organs in burned rats with delayed resuscitation].
Publication Type: Academic Journal
Source(s): Zhonghua wei zhong bing ji jiu yi xue [Zhonghua Wei Zhong Bing Ji Jiu Yi Xue] 2022 Nov; Vol. 34 (11), pp. 1138-1143.
Abstract: Objective: To study the antioxidant protective effects of different low-dose of insulin glargine on organs of burned rats with delayed resuscitation.Methods: Forty male Sprague-Dawley (SD) rats were randomly divided into sham group, delayed resuscitati...
17beta-estradiol alleviates contusion-induced skeletal muscle injury by decreasing oxidative stress via SIRT1/PGC-1α/Nrf2 pathway.
Publication Type: Academic Journal
Source(s): Steroids [Steroids] 2023 Mar; Vol. 191, pp. 109160. Date of Electronic Publication: 2022 Dec 24.
Abstract: Purpose: This study aimed to investigate the role of 17β-estradiol (E 2 ) in the repair of contusion-induced myoinjury in mice and to identify the underlying molecular mechanisms.Methods: In vivo, contusion protocol was performed for preparing mice myo...
β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Feb 14; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 14.
Abstract: The mechanisms of acute kidney injury and chronic kidney disease remain incompletely revealed, and drug development is a pressing clinical challenge. Oxidative stress-induced cellular senescence and mitochondrial damage are important biological events ...