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Antithymocyte Globulin Inhibits CD8 + T Cell Effector Functions via the Paracrine Induction of PDL-1 on Monocytes.
Publication Type: Academic Journal
Source(s): Cells (2073-4409). Feb2023, Vol. 12 Issue 3, p382. 20p.
Abstract: Background: Antithymocyte globulins (ATG) are T cell-depleting antibodies used in solid organ transplantation for induction therapy in sensitized patients with a high risk of graft rejection. Previously described effects besides the depletion of T cell...
Paracrine and endocrine functions of osteocytes.
Publication Type: Academic Journal
Source(s): Clinical Pediatric Endocrinology. 2023, Vol. 32 Issue 1, p1-10. 10p.
Abstract: Osteocytes are dendritic-shaped cells embedded in the bone matrix and are terminally differentiated from osteoblasts. Inaccessibility due to their location has hindered the understanding of the molecular functions of osteocytes. However, scientific adv...
Pharmacological Preconditioning Improves the Viability and Proangiogenic Paracrine Function of Hydrogel-Encapsulated Mesenchymal Stromal Cells.
Publication Type: Academic Journal
Source(s): Stem Cells International. 7/29/2021, p1-12. 12p.
Abstract: The efficacy of cell therapy is limited by low retention and survival of transplanted cells in the target tissues. In this work, we hypothesize that pharmacological preconditioning with celastrol, a natural potent antioxidant, could improve the viabili...
An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation.
Publication Type: Academic Journal
Source(s): Cell & Bioscience. 11/10/2022, Vol. 12 Issue 1, p1-15. 15p.
Abstract: Background: Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular, Class 3 Sema (Sema 3) is among the best characterized Sema family members and the only produced as secre...
Regulatory TÂ cells as metabolic sensors.
Publication Type: Academic Journal
Source(s): Immunity (10747613). Nov2022, Vol. 55 Issue 11, p1981-1992. 12p.
Abstract: Compelling experimental evidence links immunity and metabolism. In this perspective, we propose forkhead-box-P3 (FoxP3)+CD4+CD25+ regulatory T (Treg) cells as key metabolic sensors controlling the immunological state in response to their intrinsic capa...
Platelet-Derived S1P and Its Relevance for the Communication with Immune Cells in Multiple Human Diseases.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Sep2022, Vol. 23 Issue 18, pN.PAG-N.PAG. 19p.
Abstract: Sphingosine-1-phosphate (S1P) is a versatile signaling lipid involved in the regulation of numerous cellular processes. S1P regulates cellular proliferation, migration, and apoptosis as well as the function of immune cells. S1P is generated from sphing...
Muse cells: ushering in a new era of stem cell-based therapy for stroke.
Publication Type: Academic Journal
Source(s): Stem Cell Research & Therapy. 8/19/2022, Vol. 13 Issue 1, p1-14. 14p.
Abstract: Stem cell-based regenerative therapies have recently become promising and advanced for treating stroke. Mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) have received the most attention for treating stroke because of the outstan...
Overexpression of FoxM1 optimizes the therapeutic effect of bone marrow mesenchymal stem cells on acute respiratory distress syndrome.
Publication Type: Academic Journal
Source(s): Stem Cell Research & Therapy; 2/14/2023, Vol. 14 Issue 1, p1-19, 19p
Abstract: Copyright of Stem Cell Research & Therapy is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, down...
Characterization of the Proteins Secreted by Equine Muscle-Derived Mesenchymal Stem Cells Exposed to Cartilage Explants in Osteoarthritis Model.
Publication Type: Academic Journal
Source(s): Stem Cell Reviews & Reports; Feb2023, Vol. 19 Issue 2, p550-567, 18p
Abstract: Copyright of Stem Cell Reviews & Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, down...
Therapeutic potential of mesenchymal stem/stromal cells (MSCs)-based cell therapy for inflammatory bowel diseases (IBD) therapy.
Publication Type: Academic Journal
Source(s): European Journal of Medical Research; 1/27/2023, Vol. 28 Issue 1, p1-24, 24p
Abstract: Copyright of European Journal of Medical Research is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may pri...