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Advanced Search Results For "PARKINSON'S disease"

1 - 10 of 200,435 results for
 "PARKINSON'S disease"
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Age-dependent neurodegeneration and neuroinflammation in a genetic A30P/A53T double-mutated α-synuclein mouse model of Parkinson's disease.

Publication Type:Academic Journal

Source(s):Neurobiology of disease [Neurobiol Dis] 2022 Sep; Vol. 171, pp. 105798. Date of Electronic Publication: 2022 Jun 21.

Abstract:The pathogenesis of Parkinson's disease (PD) is closely interwoven with the process of aging. Moreover, increasing evidence from human postmortem studies and from animal models for PD point towards inflammation as an additional factor in disease develo...

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The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies.

Publication Type:Academic Journal

Source(s):Neurochemistry international [Neurochem Int] 2022 Sep; Vol. 158, pp. 105376. Date of Electronic Publication: 2022 Jun 03.

Abstract:Neurodegenerative disorders Parkinson's disease is a progressive neurodegenerative disorder associated with neuroinflammatory responses that lead to the neurodegeneration of the dopaminergic neurons. These neuroinflammatory mechanisms involve various c...

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Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae.

Publication Type:Academic Journal

Source(s):Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2022 Aug; Vol. 129 (8), pp. 1023-1030. Date of Electronic Publication: 2022 Jul 11.

Abstract:White Matter Lesions (WML) are a radiological finding common in aged subjects. We explored the impact of WML on underlying neurodegenerative processes. We focused on the impact of WML on two neurodegenerative diseases with different pathology. In this ...

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Cannabidiol Alleviates the Damage to Dopaminergic Neurons in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease Mice Via Regulating Neuronal Apoptosis and Neuroinflammation.

Publication Type:Academic Journal

Source(s):Neuroscience [Neuroscience] 2022 Aug 21; Vol. 498, pp. 64-72. Date of Electronic Publication: 2022 Jul 02.

Abstract:Parkinson's disease (PD) is a complex and multifactorial neurodegenerative disease. The main pathological feature of PD is the loss or apoptosis of dopaminergic neurons in the substantia nigra (SN). This study aimed to investigate the protective effect...

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l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease.

Publication Type:Academic Journal

Source(s):Drug and chemical toxicology [Drug Chem Toxicol] 2022 Sep; Vol. 45 (5), pp. 2097-2108. Date of Electronic Publication: 2021 Jul 01.

Abstract:Parkinson's disease (PD) is the second most prevalent progressive neurodegenerative disease, characterized by loss of dopaminergic neurons in substantia nigra, with deficiency of dopamine in the striatum. Tramadol is safe analgesic but long-term use co...

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Mangiferin, a natural glucoxilxanthone, inhibits mitochondrial dynamin-related protein 1 and relieves aberrant mitophagic proteins in mice model of Parkinson's disease.

Publication Type:Academic Journal

Source(s):Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2022 Sep; Vol. 104, pp. 154281. Date of Electronic Publication: 2022 Jun 16.

Abstract:Background: Parkinson's disease (PD) is the second most common neurodegenerative disease featured to mitochondrial dysfunction in neuronal cells. Dynamin-related protein 1 (Drp1) is an important regulator of mitochondrial fission and subsequent mitopha...

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Effects of hCG on DA neuronal death of Parkinson's disease.

Publication Type:Academic Journal

Source(s):Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Aug 30; Vol. 617 (Pt 2), pp. 41-47. Date of Electronic Publication: 2022 May 30.

Abstract:Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, with the incidence in men being about twice as compared to women. Gender differences may provide clues for finding key targets that mediate the death of dopaminergi...

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N-cystaminylbiguanide MC001 prevents neuron cell death and alleviates motor deficits in the MPTP-model of Parkinson's disease.

Publication Type:Academic Journal

Source(s):Neuroscience letters [Neurosci Lett] 2022 Jul 27; Vol. 784, pp. 136751. Date of Electronic Publication: 2022 Jun 20.

Abstract:Parkinson's disease (PD) is a common neurodegenerative disease characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra (SN), which is highly associated with oxidative stress. Antioxidants are therefore considered as p...

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Cholecystokinin and glucagon-like peptide-1 analogues regulate intestinal tight junction, inflammation, dopaminergic neurons and α-synuclein accumulation in the colon of two Parkinson's disease mouse models.

Publication Type:Academic Journal

Source(s):European journal of pharmacology [Eur J Pharmacol] 2022 Jul 05; Vol. 926, pp. 175029. Date of Electronic Publication: 2022 May 15.

Abstract:Parkinson's disease (PD) is the second most common neurodegenerative disease, and no treatment is available to stop its progression. Studies have shown that the colonic pathology of PD precedes that of the brain. The 1-Methyl-4-phenyl-1,2,3,6-tetrahydr...

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Loss of tau expression attenuates neurodegeneration associated with α-synucleinopathy.

Publication Type:Academic Journal

Source(s):Translational neurodegeneration [Transl Neurodegener] 2022 Jul 01; Vol. 11 (1), pp. 34. Date of Electronic Publication: 2022 Jul 01.

Abstract:Background: Neuronal dysfunction and degeneration linked to α-synuclein (αS) pathology is thought to be responsible for the progressive nature of Parkinson's disease and related dementia with Lewy bodies. Studies have indicated bidirectional pathologic...

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