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A novel cyclic peptide library immobilized on gel-type beads focusing on rapid construction and characterization for comprehensive drug discovery.
Publication Type: Academic Journal
Source(s): Chemical biology & drug design [Chem Biol Drug Des] 2023 Dec; Vol. 102 (6), pp. 1327-1335. Date of Electronic Publication: 2023 Sep 01.
Abstract: Medium sized molecules such as peptides and macrocycles have recently drawn much attention as potent sources of medicinal lead compounds, whereas the possibility of obtaining a practical drug from them remains limited. The present paper describes a con...
Self-Entrapment of Antimicrobial Peptides in Silica Particles for Stable and Effective Antimicrobial Peptide Delivery System.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Nov 16; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 16.
Abstract: Antimicrobial peptides (AMPs) have emerged as a promising solution to tackle bacterial infections and combat antibiotic resistance. However, their vulnerability to protease degradation and toxicity towards mammalian cells has hindered their clinical ap...
A novel genetically-encoded bicyclic peptide inhibitor of human urokinase-type plasminogen activator with better cross-reactivity toward the murine orthologue.
Publication Type: Academic Journal
Source(s): Bioorganic & medicinal chemistry [Bioorg Med Chem] 2023 Nov 15; Vol. 95, pp. 117499. Date of Electronic Publication: 2023 Oct 12.
Abstract: The inhibition of human urokinase-type plasminogen activator (huPA), a serine protease that plays an important role in pericellular proteolysis, is a promising strategy to decrease the invasive and metastatic activity of tumour cells. However, the gene...
Gene deletion of the PACAP/VIP receptor, VPAC2R, alters glycemic responses during metabolic and psychogenic stress in adult female mice.
Publication Type: Academic Journal
Source(s): Journal of neuroendocrinology [J Neuroendocrinol] 2023 Nov; Vol. 35 (11), pp. e13354. Date of Electronic Publication: 2023 Nov 10.
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) and the homologous peptide, vasoactive intestinal peptide (VIP), participate in glucose homeostasis using insulinotropic and counterregulatory processes. The role of VIP receptor 2 (VPAC2R) in ...
Pharmaceutical aspects of novel CGRP inhibitors used in the prophylaxis and treatment of migraine.
Publication Type: Academic Journal
Source(s): Inflammopharmacology [Inflammopharmacology] 2023 Oct; Vol. 31 (5), pp. 2245-2251. Date of Electronic Publication: 2023 Jul 08.
Abstract: Migraine is one of the most prevalent neurological disorders known to have an immense adverse socio-economic impact. Neurogenic inflammation is thought to mediate migraine, and CGRP is known to be released during acute attacks of migraine that causes v...
Peptide Nucleic Acids: Recent Developments in the Synthesis and Backbone Modifications.
Publication Type: Academic Journal
Source(s): Bioorganic chemistry [Bioorg Chem] 2023 Dec; Vol. 141, pp. 106860. Date of Electronic Publication: 2023 Sep 18.
Abstract: Nucleic acid represents the ideal drug candidate for protein targets that are hard to target or against which drug development is not easy. Peptide nucleic acids (PNAs) are synthesized by attaching modified peptide backbones generally derived from repe...
Effect of tandem repeats of antimicrobial peptide CC34 on production of target proteins and activity of Pichia pastoris.
Publication Type: Academic Journal
Source(s): Protein expression and purification [Protein Expr Purif] 2023 Dec; Vol. 212, pp. 106342. Date of Electronic Publication: 2023 Aug 02.
Abstract: Antimicrobial peptides (AMPs) are attracting attention in the fields of medicine, food, and agriculture because of their broad-spectrum antibacterial properties, low resistance, and low-residue in the body. However, the low yield and instability of the...
Design methods for antimicrobial peptides with improved performance.
Publication Type: Academic Journal
Source(s): Zoological research [Zool Res] 2023 Nov 18; Vol. 44 (6), pp. 1095-1114.
Abstract: The recalcitrance of pathogens to traditional antibiotics has made treating and eradicating bacterial infections more difficult. In this regard, developing new antimicrobial agents to combat antibiotic-resistant strains has become a top priority. Antim...
Nucleation and Growth of Amyloid Fibrils.
Publication Type: Academic Journal
Source(s): The journal of physical chemistry. B [J Phys Chem B] 2023 Nov 16; Vol. 127 (45), pp. 9759-9770. Date of Electronic Publication: 2023 Nov 07.
Abstract: The formation of amyloid fibrils is a complex phenomenon that remains poorly understood at the atomic scale. Herein, we perform extended unbiased all-atom simulations in explicit solvent of a short amphipathic peptide to shed light on the three mechani...
Exploring the Release of Elastin Peptides Generated from Enzymatic Hydrolysis of Bovine Elastin via Peptide Mapping.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2023 Nov 10; Vol. 28 (22). Date of Electronic Publication: 2023 Nov 10.
Abstract: To enhance the understanding of enzymatic hydrolysis and to accelerate the discovery of key bioactive peptides within enzymatic products, this research focused on elastin as the substrate and investigated the variations in peptide profiles and the prod...