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Advanced Search Results For "PEPTIDES"

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 "PEPTIDES"
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AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys 25 -Cys 192 ) formation of functional significance for VIPR2.

Publication Type: Academic Journal

Source(s): Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Dec 25; Vol. 636 (Pt 1), pp. 10-16. Date of Electronic Publication: 2022 Oct 23.

Abstract: The vasoactive intestinal peptide receptor 2 (VIPR2) has attracted attention as a drug target for the treatment of mental disorders, cancer, and immune diseases. In 2021, we identified the peptide KS-133 as a VIPR2-selective antagonist. In this study, ...

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Expanding the Landscape of Amino Acid-Rich Antimicrobial Peptides: Definition, Deployment in Nature, Implications for Peptide Design and Therapeutic Potential.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Oct 25; Vol. 23 (21). Date of Electronic Publication: 2022 Oct 25.

Abstract: Unlike the α-helical and β-sheet antimicrobial peptides (AMPs), our knowledge on amino acid-rich AMPs is limited. This article conducts a systematic study of rich AMPs (>25%) from different life kingdoms based on the Antimicrobial Peptide Database (APD...

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Virtual drug repurposing study for the CGRPR identifies pentagastrin and leuprorelin as putative candidates.

Publication Type: Academic Journal

Source(s): Journal of molecular graphics & modelling [J Mol Graph Model] 2022 Nov; Vol. 116, pp. 108254. Date of Electronic Publication: 2022 Jun 18.

Abstract: Calcitonin gene-related peptide receptor (CGRPR) is a heterodimer consisting of CLR and RAMP1 proteins. Activation of the CGRPR with the endogenous peptide CGRP is known to play a crucial role in migraine pathophysiology. CGRP occupies two regions in t...

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Involvement of trigeminal axons in nose-to-brain delivery of glucagon-like peptide-2 derivative.

Publication Type: Academic Journal

Source(s): Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2022 Nov; Vol. 351, pp. 573-580. Date of Electronic Publication: 2022 Sep 30.

Abstract: In our previous study, we created a glucagon-like peptide-2 (GLP-2) derivative with the functional sequence PAS-CPP to achieve efficient uptake by the respiratory epithelium and trigeminal nerve. By using octaarginine for cell penetrating peptides (CPP...

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Proteomics Characterization of Food-Derived Bioactive Peptides with Anti-Allergic and Anti-Inflammatory Properties.

Publication Type: Academic Journal

Source(s): Nutrients [Nutrients] 2022 Oct 20; Vol. 14 (20). Date of Electronic Publication: 2022 Oct 20.

Abstract: Bioactive peptides are found in foods and dietary supplements and are responsible for health benefits with applications in human and animal medicine. The health benefits include antihypertensive, antimicrobial, antithrombotic, immunomodulatory, opioid,...

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Characterization of MroQ-Dependent Maturation and Export of the Staphylococcus aureus Accessory Gene Regulatory System Autoinducing Peptide.

Publication Type: Academic Journal

Source(s): Infection and immunity [Infect Immun] 2022 Oct 20; Vol. 90 (10), pp. e0026322. Date of Electronic Publication: 2022 Sep 08.

Abstract: Gram-positive bacteria produce small autoinducing peptides (AIPs), which act to regulate expression of genes that promote adaptive traits, including virulence. The Gram-positive pathogen Staphylococcus aureus generates a cyclic AIP that controls expres...

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Investigation of the Role of Hydrophobic Amino Acids on the Structure-Activity Relationship in the Antimicrobial Venom Peptide Ponericin L1.

Publication Type: Academic Journal

Source(s): The Journal of membrane biology [J Membr Biol] 2022 Oct; Vol. 255 (4-5), pp. 537-551. Date of Electronic Publication: 2021 Nov 18.

Abstract: Venom mixtures from insects, reptiles, and mollusks have long been a source of bioactive peptides which often have alternative uses as therapeutics. While these molecules act in numerous capacities, there have been many venom components that act on the...

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Stability, Bioavailability, and Structure-Activity Relationship of Casein-Derived Peptide YPVEPF with a Sleep-Enhancing Effect.

Publication Type: Academic Journal

Source(s): Journal of agricultural and food chemistry [J Agric Food Chem] 2022 Nov 30; Vol. 70 (47), pp. 14947-14958. Date of Electronic Publication: 2022 Nov 16.

Authors:

Abstract: YPVEPF (Tyr-Pro-Val-Glu-Pro-Phe) is an outstanding sleep-enhancing peptide derived from casein. This study aimed to evaluate the bioavailability of YPVEPF in vitro and in vivo and to explore its structure-activity relationship through a sleep test and ...

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Advance and Designing Strategies in Polymeric Antifungal Agents Inspired by Membrane-Active Peptides.

Publication Type: Academic Journal

Source(s): Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Nov 21; Vol. 28 (65), pp. e202202226. Date of Electronic Publication: 2022 Sep 15.

Authors:

Abstract: The high-mortality invasive fungal infections seriously threaten the lives of immunocompromised people. Host defense peptides and cell-penetrating peptides are representative membrane-active peptides with different functions. Among them, host defense p...

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Key Residue for Aggregation of Amyloid-β Peptides.

Publication Type: Academic Journal

Source(s): ACS chemical neuroscience [ACS Chem Neurosci] 2022 Nov 16; Vol. 13 (22), pp. 3139-3151. Date of Electronic Publication: 2022 Oct 27.

Abstract: It is known that oligomers of amyloid-β (Aβ) peptide are associated with Alzheimer's disease. Aβ has two isoforms: Aβ40 and Aβ42. Although the difference between Aβ40 and Aβ42 is only two additional C-terminal residues, Aβ42 aggregates much faster than...

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