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Ophthalmic Bimatoprost-Loaded Niosomal In Situ Gel: Preparation, Optimization, and In Vivo Pharmacodynamics Study.

Publication Type: Academic Journal

Source(s): Polymers (20734360). Nov2023, Vol. 15 Issue 21, p4336. 18p.

Abstract: This study aimed at formulating the antiglaucoma agent, Bimatoprost (BMT), into niosomal in situ gel (BMT-ISG) for ocular delivery. Niosomes containing cholesterol/span 60 entrapping BMT were fabricated using a thin-film hydration method. The fabricate...

The Progress in the Application of Dissolving Microneedles in Biomedicine.

Publication Type: Academic Journal

Source(s): Polymers (20734360). Oct2023, Vol. 15 Issue 20, p4059. 19p.

Abstract: In recent years, microneedle technology has been widely used for the transdermal delivery of substances, showing improvements in drug delivery effects with the advantages of minimally invasive, painless, and convenient operation. With the development o...

Modeling experimental glaucoma for screening studies of antiglaucomatous activity.

Publication Type: Academic Journal

Source(s): Research Results in Pharmacology. 2023, Vol. 9 Issue 4, p13-19. 7p.

Abstract: Introduction: In vivo screening studies, in which the efficacy of dozens of drugs is tested to select several applicants for further study of their safety in humans, are the main stage in the study of the pharmacodynamics of promising antiglaucoma drug...

Sexually Dimorphic Effects of Neuromodulatory Drugs on Normal and Stress-Induced Social Interaction in Rats.

Publication Type: Academic Journal

Source(s): Brain Sciences (2076-3425). Oct2023, Vol. 13 Issue 10, p1378. 17p.

Abstract: Social behavior is a complex term which involves different interactions between various individuals of a community. It is controlled by different neurotransmitter systems in a sexually dimorphic way. Certain environmental factors, like stress, cause va...

In Vitro Activity of Isavuconazole and Amphotericin B in Association against Mucorales.

Publication Type: Academic Journal

Source(s): Pathogens. Jul2023, Vol. 12 Issue 7, p948. 6p.

Abstract: Mucormycoses can be treated with the combination of Amphotericin B and Isavuconazole. This study evaluates the effects of these drugs in vitro against 59 strains representing 12 Mucorales. In vitro testing of the two drugs together and alone was perfor...

Tablet Geometry Effect on the Drug Release Profile from a Hydrogel-Based Drug Delivery System.

Publication Type: Academic Journal

Source(s): Pharmaceutics. Jul2023, Vol. 15 Issue 7, p1917. 22p.

Abstract: In order to achieve the optimal level of effectiveness and safety of drugs, it is necessary to control the drug release rate. Therefore, it is important to discover the factors affecting release profile from a drug delivery system. Geometry is one of t...

Rapid In Vitro Assessment of Antimicrobial Drug Effect Bridging Clinically Relevant Pharmacokinetics: A Comprehensive Methodology.

Publication Type: Academic Journal

Source(s): Pharmaceutics. Jun2023, Vol. 15 Issue 6, p1671. 13p.

Abstract: Rapid in vitro assessment of antimicrobial drug efficacy under clinically relevant pharmacokinetic conditions is an essential element of both drug development and clinical use. Here, we present a comprehensive overview of a recently developed novel int...

Curcuminoids as Anticancer Drugs: Pleiotropic Effects, Potential for Metabolic Reprogramming and Prospects for the Future.

Publication Type: Academic Journal

Source(s): Pharmaceutics. Jun2023, Vol. 15 Issue 6, p1612. 31p.

Abstract: The number of published studies on curcuminoids in cancer research, including its lead molecule curcumin and synthetic analogs, has been increasing substantially during the past two decades. Insights on the diversity of inhibitory effects they have pro...

Association between Food/UGT2B7 Polymorphisms and Pharmacokinetics/Pharmacodynamics Properties of Indapamide in Healthy Humans.

Publication Type: Academic Journal

Source(s): Biomedicines. May2023, Vol. 11 Issue 5, p1501. 14p.

Abstract: Indapamide is an effective and safe antihypertensive medication showing a beneficial effect in combination with other antihypertensive agents regarding morbidity and mortality. A comparative study was performed under fasting and fed conditions to inves...

Combination of Farnesol with Common Antifungal Drugs: Inhibitory Effect against Candida Species Isolated from Women with RVVC.

Publication Type: Academic Journal

Source(s): Medicina (1010660X). Apr2023, Vol. 59 Issue 4, p743. 11p.

Abstract: Background and Objectives: Vulvovaginal candidiasis (VVC) is a mucous membrane infection, with an increased rate of antifungal resistance of Candida species. In this study, the in vitro efficacy of farnesol alone or in combination with traditional anti...