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Advanced Search Results For "PHARMACOKINETICS"

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 "PHARMACOKINETICS"
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Unravelling sex-specific BPA toxicokinetics in children using a pediatric PBPK model.

Publication Type: Academic Journal

Source(s): Environmental research [Environ Res] 2022 Dec; Vol. 215 (Pt 1), pp. 114074. Date of Electronic Publication: 2022 Aug 19.

Abstract: Bisphenol A (BPA) is a widely known endocrine disruptor (ED) found in many children's products such as toys, feeding utensils, and teething rings. Recent epidemiology association studies have shown postnatal BPA exposure resulted in developing various ...

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Bioavailability and health risk of toxic heavy metals (As, Hg, Pb and Cd) in urban soils: A Monte Carlo simulation approach.

Publication Type: Academic Journal

Source(s): Environmental research [Environ Res] 2022 Nov; Vol. 214 (Pt 1), pp. 113772. Date of Electronic Publication: 2022 Jul 02.

Authors:

Abstract: Toxic heavy metals pollution in urban soil has become a major global issue due to its adverse effects on the environment and human health. In this paper, 26 soil samples were analyzed to assess the speciation, bioavailability and human health risk of A...

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Safety, Tolerability, and Pharmacokinetics of the Novel Antiviral Agent Ensitrelvir Fumaric Acid, a SARS-CoV-2 3CL Protease Inhibitor, in Healthy Adults.

Publication Type: Academic Journal

Source(s): Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 Oct 18; Vol. 66 (10), pp. e0063222. Date of Electronic Publication: 2022 Sep 12.

Abstract: Ensitrelvir is a novel selective inhibitor of the 3C-like protease of SARS-CoV-2, which is essential for viral replication. This phase 1 study of ensitrelvir assessed its safety, tolerability, and pharmacokinetics of single (part 1, n  = 50) and multip...

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Effect of fluconazole on the pharmacokinetics of a single dose of fedratinib in healthy adults.

Publication Type: Academic Journal

Source(s): Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2022 Oct; Vol. 90 (4), pp. 325-334. Date of Electronic Publication: 2022 Aug 24.

Abstract: Purpose: Fedratinib is an orally administered Janus kinase (JAK) 2-selective inhibitor for the treatment of adult patients with intermediate-2 or high-risk primary or secondary myelofibrosis. In vitro, fedratinib is predominantly metabolized by cytochr...

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Physiologically based pharmacokinetic modeling of ponatinib to describe drug-drug interactions in patients with cancer.

Publication Type: Academic Journal

Source(s): Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2022 Oct; Vol. 90 (4), pp. 315-323. Date of Electronic Publication: 2022 Aug 23.

Authors:

Abstract: Purpose: This study aimed to investigate the drug-drug interactions of ponatinib with strong, moderate, or weak CYP3A4 inhibitors/inducers by developing physiologically based pharmacokinetic (PBPK) models.Methods: Simcyp ® Ver 20.1 (Certara Inc., Sheff...

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Impact of cumulative fluid balance on the pharmacokinetics of extended infusion meropenem in critically ill patients with sepsis.

Publication Type: Academic Journal

Source(s): Critical care (London, England) [Crit Care] 2021 Jul 17; Vol. 25 (1), pp. 251. Date of Electronic Publication: 2021 Jul 17.

Abstract: Background: Meropenem dosing for septic critically patients is difficult due to pathophysiological changes associated with sepsis as well as supportive symptomatic therapies. A prospective single-center study assessed whether fluid retention alters mer...

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Nonparametric Methods in Population Pharmacokinetics.

Publication Type: Academic Journal

Source(s): Journal of clinical pharmacology [J Clin Pharmacol] 2022 Feb; Vol. 62 (2), pp. 142-157. Date of Electronic Publication: 2020 Oct 26.

Abstract: Population pharmacokinetic (PK) modeling is a widely used approach to analyze PK data obtained from groups of individuals, in both industry and academic research. The approach can also be used to analyze pharmacodynamic (PD) data and pooled PK/PD data....

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Discovery of a novel water-soluble, rapid-release triptolide prodrug with improved drug-like properties and high efficacy in human acute myeloid leukemia.

Publication Type: Academic Journal

Source(s): European journal of medicinal chemistry [Eur J Med Chem] 2022 Dec 05; Vol. 243, pp. 114694. Date of Electronic Publication: 2022 Sep 05.

Authors:

Abstract: In this work, a series of water-soluble triptolide prodrugs were synthesized, and their triptolide release rate, pharmacokinetic characteristics and anti-tumor effect were measured. We found that inserting glycolic acid as a linker between triptolide a...

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Dose optimization with population pharmacokinetics of ritonavir-boosted lopinavir for Thai people living with HIV with and without active tuberculosis.

Publication Type: Academic Journal

Source(s): Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2022 Dec; Vol. 47, pp. 100478. Date of Electronic Publication: 2022 Oct 19.

Abstract: Background: Prior to dolutegravir availability, ritonavir-boosted lopinavir (LPV/r) was an alternative recommendation when first-line drugs could not be used. A high concentration of protease inhibitors was observed in the Thai people living with HIV (...

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Microdialysis of Drug and Drug Metabolite: a Comprehensive In Vitro Analysis for Voriconazole and Voriconazole N-oxide.

Publication Type: Academic Journal

Source(s): Pharmaceutical research [Pharm Res] 2022 Nov; Vol. 39 (11), pp. 2991-3003. Date of Electronic Publication: 2022 Sep 28.

Abstract: Purpose: Voriconazole is a therapeutically challenging antifungal drug associated with high interindividual pharmacokinetic variability. As a prerequisite to performing clinical trials using the minimally-invasive sampling technique microdialysis, a co...

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