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Interplay between C1-inhibitor and group IIA secreted phospholipase A 2 impairs their respective function.
Publication Type: Academic Journal
Source(s): Immunologic research [Immunol Res] 2023 Feb; Vol. 71 (1), pp. 70-82. Date of Electronic Publication: 2022 Nov 17.
Abstract: High levels of human group IIA secreted phospholipase A 2 (hGIIA) have been associated with various inflammatory disease conditions. We have recently shown that hGIIA activity and concentration are increased in the plasma of patients with hereditary an...
Inhibition of sPLA 2 enzyme activity by cell-permeable antioxidant EUK-8 and downregulation of p38, Akt, and p65 signals induced by sPLA 2 in inflammatory mouse paw edema model.
Publication Type: Academic Journal
Source(s): Journal of cellular biochemistry [J Cell Biochem] 2023 Feb; Vol. 124 (2), pp. 294-307. Date of Electronic Publication: 2022 Dec 31.
Abstract: The arachidonic acid (AA) metabolic pathway, plays a vital role in the production of eicosanoids by the action of pro-inflammatory secretory phospholipase A 2 (PLA 2 ). Release of eicosanoids is known to be involved in many inflammatory diseases. Ident...
Cervical sympathetic trunk transection alleviates acute lung injury caused by intestinal obstruction via inhibition of phospholipase A 2 in rats.
Publication Type: Academic Journal
Source(s): BMC anesthesiology [BMC Anesthesiol] 2022 Aug 23; Vol. 22 (1), pp. 270. Date of Electronic Publication: 2022 Aug 23.
Abstract: Background: Intestinal obstruction can result in inflammatory injury to distant organs, especially the lungs. Stellate ganglion block (SGB) provides sympathetic nervous homeostasis and inhibits the systemic inflammatory response. This study aimed to in...
Fexofenadine protects against lipopolysaccharide-induced acute lung injury by targeting cytosolic phospholipase A2.
Publication Type: Academic Journal
Source(s): International immunopharmacology [Int Immunopharmacol] 2023 Mar; Vol. 116, pp. 109637. Date of Electronic Publication: 2023 Feb 08.
Abstract: Objective: Acute lung injury (ALI) causes acute respiratory distress syndrome, with a high mortality rate of 40%, with currently available pharmacological treatments. Cytosolic phospholipase A2 (cPLA2) plays a critical role in the lipopolysaccharide (L...
Structural and functional characterization of a thermostable secretory phospholipase A 2 from Sciscionella marina and its application in liposome biotransformation.
Publication Type: Academic Journal
Source(s): Acta crystallographica. Section D, Structural biology [Acta Crystallogr D Struct Biol] 2023 Feb 01; Vol. 79 (Pt 2), pp. 188-197. Date of Electronic Publication: 2023 Feb 06.
Abstract: Secretory phospholipase A 2 (sPLA 2 ), which hydrolyzes the sn-2 acyl bond of lecithin in a Ca 2+ -dependent manner, is an important enzyme in the oil and oleochemical industries. However, most sPLA 2 s are not stable under process conditions. Therefor...
The Phospholipase A2 Superfamily: Structure, Isozymes, Catalysis, Physiologic and Pathologic Roles.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jan 10; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 10.
Abstract: The phospholipase A2 (PLA2) superfamily of phospholipase enzymes hydrolyzes the ester bond at the sn-2 position of the phospholipids, generating a free fatty acid and a lysophospholipid. The PLA2s are amphiphilic in nature and work only at the water/li...
Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis.
Publication Type: Academic Journal
Source(s): Frontiers in immunology [Front Immunol] 2023 Jan 04; Vol. 13, pp. 1094375. Date of Electronic Publication: 2023 Jan 04 (Print Publication: 2022).
Abstract: Introduction: Psoriasis is a common inflammatory skin disease recognized by the World Health Organization as "an incurable chronic, noninfectious, painful, disfiguring and disabling disease." The fact that metabolic syndrome (MetS) is the most common a...
Heterologous Expression and Immunogenic Potential of the Most Abundant Phospholipase A 2 from Coral Snake Micrurus dumerilii to Develop Antivenoms.
Publication Type: Academic Journal
Source(s): Toxins [Toxins (Basel)] 2022 Nov 24; Vol. 14 (12). Date of Electronic Publication: 2022 Nov 24.
Abstract: Micrurus dumerilii is a coral snake of clinic interest in Colombia. Its venom is mainly composed of phospholipases A 2 being MdumPLA 2 the most abundant protein. Nevertheless, Micrurus species produce a low quantity of venom, which makes it difficult t...
Syringol isolated from Eleusine coracana (L.) Gaertn bran suppresses inflammatory response through the down-regulation of cPLA 2 , COX-2, IκBα, p38 and MPO signaling in sPLA 2 induced mice paw oedema.
Publication Type: Academic Journal
Source(s): Inflammopharmacology [Inflammopharmacology] 2022 Oct; Vol. 30 (5), pp. 1853-1870. Date of Electronic Publication: 2022 May 31.
Abstract: Eleusine coracana (L.) Gaertn (E. coracana) is one of the highest consuming food crops in Asia and Africa. E. coracana is a plant with several medicinal values including anti-ulcerative, anti-diabetic, anti-viral and anti-cancer properties. However, th...
Trans triacylglycerols from dairy products and industrial hydrogenated oil exhibit different effects on the function of human umbilical vein endothelial cells via modulating phospholipase A2/arachidonic acid metabolism pathways.
Publication Type: Academic Journal
Source(s): Journal of dairy science [J Dairy Sci] 2021 Jun; Vol. 104 (6), pp. 6399-6414. Date of Electronic Publication: 2021 Mar 25.
Abstract: Dairy fat intake has been considered as a risk factor for cardiovascular disease. Rodent models show that trans fatty acids in industrial hydrogenated oil and ruminant milk have different effects on cardiovascular diseases. One of the main reasons is t...