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Advanced Search Results For "POLYOMAVIRUSES"

1 - 10 of 15,470 results for
 "POLYOMAVIRUSES"
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Lyon IARC Polyomavirus Displays Transforming Activities in Primary Human Cells.

Publication Type: Academic Journal

Source(s): Journal of virology [J Virol] 2022 Jul 27; Vol. 96 (14), pp. e0206121. Date of Electronic Publication: 2022 Jun 30.

Abstract: Several studies reported the presence of a recently discovered polyomavirus (PyV), Lyon IARC PyV (LIPyV), in human and domestic animal specimens. LIPyV has some structural similarities to well-established animal and human oncogenic PyVs, such as raccoo...

Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development.

Publication Type: Academic Journal

Source(s): PLoS pathogens [PLoS Pathog] 2022 May 13; Vol. 18 (5), pp. e1010551. Date of Electronic Publication: 2022 May 13 (Print Publication: 2022).

Abstract: Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC). Integration of viral DNA into the human genome facilitates continued expression of the MCPyV ...

Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma.

Publication Type: Academic Journal

Source(s): JCI insight [JCI Insight] 2022 Jul 08; Vol. 7 (13). Date of Electronic Publication: 2022 Jul 08.

Abstract: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin with 2 etiologies. Merkel cell polyomavirus (MCPyV) integration is present in about 80% of all MCC. Virus-positive MCC (MCCP) tumors have few somatic mutations and usuall...

Polyomavirus exerts detrimental effects on renal function in patients after lung transplantation.

Publication Type: Academic Journal

Source(s): Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2021 Dec; Vol. 145, pp. 105029. Date of Electronic Publication: 2021 Nov 13.

Abstract: Introduction: Chronic kidney disease (CKD) is associated with significant morbidity and mortality after lung transplantation (LTX). Calcineurin inhibitor (CNI) nephrotoxicity is the leading cause of CKD. After kidney transplantation, polyomavirus-assoc...

Regulation of Transcriptional Activity of Merkel Cell Polyomavirus Large T-Antigen by PKA-Mediated Phosphorylation.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jan 03; Vol. 24 (1). Date of Electronic Publication: 2023 Jan 03.

Abstract: Merkel cell polyomavirus (MCPyV) is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. MCPyV large T-antigen (LTag) and small T-antigen (sTag) are the main oncoproteins involved in MCPyV-induced MCC. A hallmark of MCPyV-positive...

Small DNA tumor viruses and human cancer: Preclinical models of virus infection and disease.

Publication Type: Academic Journal

Source(s): Tumour virus research [Tumour Virus Res] 2022 Dec; Vol. 14, pp. 200239. Date of Electronic Publication: 2022 May 27.

Authors:

Abstract: Human tumor viruses cause various human cancers that account for at least 15% of the global cancer burden. Among the currently identified human tumor viruses, two are small DNA tumor viruses: human papillomaviruses (HPVs) and Merkel cell polyomavirus (...

Deciphering the role of predicted miRNAs of polyomaviruses in carcinogenesis.

Publication Type: Academic Journal

Source(s): Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2022 Dec 01; Vol. 1868 (12), pp. 166537. Date of Electronic Publication: 2022 Sep 09.

Abstract: Human polyomaviruses are relatively common in the general population. Polyomaviruses maintain a persistent infection after initial infection in childhood, acting as an opportunistic pathogen in immunocompromised populations and their association has be...

Association between human polyomavirus infection and brain cancer: A systematic review and meta-analysis.

Publication Type: Academic Journal

Source(s): Microbial pathogenesis [Microb Pathog] 2022 Dec; Vol. 173 (Pt A), pp. 105797. Date of Electronic Publication: 2022 Sep 29.

Abstract: Aim: The aim of this study was to investigate the prevalence and potential association between the infection with some members of the polyomaviridae family of viruses and development of the brain tumors.Methods: A systematic literature search was perfo...

Distinct Radiation Responses in Virus-Positive and Virus-Negative Merkel Cell Carcinoma.

Publication Type: Academic Journal

Source(s): The Journal of investigative dermatology [J Invest Dermatol] 2023 Jan; Vol. 143 (1), pp. 166-169.e5. Date of Electronic Publication: 2022 Aug 08.

Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2021 Oct 24; Vol. 22 (21). Date of Electronic Publication: 2021 Oct 24.

Abstract: Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the skin. The role of epigenetic mechanisms, such as histone posttranslational m...

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