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Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson's Disease.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 17, p13435. 19p.
Abstract: Parkinson's disease (PD) pathology is characterized by the loss of dopaminergic neurons of the nigrostriatal system and accumulation of Lewy bodies (LB) and Lewy neurites (LN), inclusions mainly composed of alpha-synuclein (α-Syn) fibrils. Studies link...
Modeling Side Chains in the Three-Dimensional Structure of Proteins for Post-Translational Modifications.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 17, p13431. 15p.
Abstract: Amino acid substitutions and post-translational modifications (PTMs) play a crucial role in many cellular processes by directly affecting the structural and dynamic features of protein interaction. Despite their importance, the understanding of protein...
The Bidirectional Interplay of α-Synuclein with Lipids in the Central Nervous System and Its Implications for the Pathogenesis of Parkinson's Disease.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 17, p13270. 28p.
Abstract: The alteration and aggregation of alpha-synuclein (α-syn) play a crucial role in neurodegenerative diseases collectively termed as synucleinopathies, including Parkinson's disease (PD). The bidirectional interaction of α-syn with lipids and biomembrane...
Glycosylation Contributes to Thermostability and Proteolytic Resistance of rFIP-nha (Nectria haematococca).
Publication Type: Academic Journal
Source(s): Molecules. Sep2023, Vol. 28 Issue 17, p6386. 13p.
Abstract: Glycosylation is an important post-translational modification of proteins, contributing to protein function, stability and subcellular localization. Fungal immunomodulatory proteins (FIPs) are a group of small proteins with notable immunomodulatory act...
Ubiquitination Is a Novel Post-Translational Modification of VMP1 in Autophagy of Human Tumor Cells.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Aug2023, Vol. 24 Issue 16, p12981. 22p.
Abstract: Autophagy is a tightly regulated catabolic process involved in the degradation and recycling of proteins and organelles. Ubiquitination plays an important role in the regulation of autophagy. Vacuole Membrane Protein 1 (VMP1) is an essential autophagy ...
The Role of Autophagy as a Trigger of Post-Translational Modifications of Proteins and Extracellular Vesicles in the Pathogenesis of Rheumatoid Arthritis.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Aug2023, Vol. 24 Issue 16, p12764. 17p.
Abstract: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, characterized by persistent joint inflammation, leading to cartilage and bone destruction. Autoantibody production is directed to post-translational modified (PTM) proteins, i.e., citr...
Human Triosephosphate Isomerase Is a Potential Target in Cancer Due to Commonly Occurring Post-Translational Modifications.
Publication Type: Academic Journal
Source(s): Molecules. Aug2023, Vol. 28 Issue 16, p6163. 21p.
Abstract: Cancer involves a series of diseases where cellular growth is not controlled. Cancer is a leading cause of death worldwide, and the burden of cancer incidence and mortality is rapidly growing, mainly in developing countries. Many drugs are currently us...
Mechanisms of Modulation of Mitochondrial Architecture.
Publication Type: Academic Journal
Source(s): Biomolecules (2218-273X). Aug2023, Vol. 13 Issue 8, p1225. 46p.
Abstract: Mitochondrial network architecture plays a critical role in cellular physiology. Indeed, alterations in the shape of mitochondria upon exposure to cellular stress can cause the dysfunction of these organelles. In this scenario, mitochondrial dynamics p...
蛋白质棕榈酰化修饰与心血管疾病.
Publication Type: Academic Journal
Source(s): Chinese Journal of Arteriosclerosis. Aug2023, Vol. 31 Issue 8, p645-653. 9p.
Abstract: 姜志胜,医学博士,二级教授,博士研究生导师,国务院政府特殊津贴获得 者,国家卫生计生突出贡献中青年专家,湖南省医学学科领军人才,湖南省 121 人才工程 第一层次人选,湖南省高校学科带头人。 长期从事动脉粥样硬化病因发病学以及心肌缺 血损伤的细胞分子机制与防治的研究。 先后主持国家级科研项目 10 余项,获省级科技成 果和教学成果一等奖和二等奖共 4 项,先后获中国侨联与国务院侨办“科技创新人才奖” “全国归侨侨眷先进个人”及“科技创新成果奖”。 在国内外知名刊物上发表论文 240 余 篇,其中,S...
Functional Diversity of Mammalian Small Heat Shock Proteins: A Review.
Publication Type: Academic Journal
Source(s): Cells (2073-4409). Aug2023, Vol. 12 Issue 15, p1947. 24p.
Abstract: The small heat shock proteins (sHSPs), whose molecular weight ranges from 12∼43 kDa, are members of the heat shock protein (HSP) family that are widely found in all organisms. As intracellular stress resistance molecules, sHSPs play an important role i...