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Advanced Search Results For "PROMOTERS"

1 - 10 of 176,148 results for
 "PROMOTERS"
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Coming full circle: On the origin and evolution of the looping model for enhancer-promoter communication.

Publication Type:Academic Journal

Source(s):The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102117. Date of Electronic Publication: 2022 Jun 09.

Abstract:In mammalian organisms, enhancers can regulate transcription from great genomic distances. How enhancers affect distal gene expression has been a major question in the field of gene regulation. One model to explain how enhancers communicate with their ...

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Characterization of divergent promoters PmaiA and Phyd from Gordonia: Co-expression and regulation by CRP.

Publication Type:Academic Journal

Source(s):Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2022 Aug; Vol. 1865 (6), pp. 194843. Date of Electronic Publication: 2022 Jul 14.

Abstract:Divergent promoters are often responsible for controlling gene expression of related genes of the same pathway or for coordinating regulation at different time points. There are relatively few reports on characterization of divergent promoters in bacte...

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dPromoter-XGBoost: Detecting promoters and strength by combining multiple descriptors and feature selection using XGBoost.

Publication Type:Academic Journal

Source(s):Methods (San Diego, Calif.) [Methods] 2022 Aug; Vol. 204, pp. 215-222. Date of Electronic Publication: 2022 Jan 05.

Abstract:Promoters play an irreplaceable role in biological processes and genetics, which are responsible for stimulating the transcription and expression of specific genes. Promoter abnormalities have been found in some diseases, and the level of promoter-bind...

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Structural Analysis of Ino2p/Ino4p Mutual Interactions and Their Binding Interface with Promoter DNA.

Publication Type:Academic Journal

Source(s):International journal of molecular sciences [Int J Mol Sci] 2022 Jul 09; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 09.

Abstract:Gene expression is mediated by a series of regulatory proteins, i.e., transcription factors. Under different growth conditions, the transcriptional regulation of structural genes is associated with the recognition of specific regulatory elements (REs) ...

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Systematic analysis of intrinsic enhancer-promoter compatibility in the mouse genome.

Publication Type:Academic Journal

Source(s):Molecular cell [Mol Cell] 2022 Jul 07; Vol. 82 (13), pp. 2519-2531.e6. Date of Electronic Publication: 2022 Apr 29.

Abstract:Gene expression is in part controlled by cis-regulatory elements (CREs) such as enhancers and repressive elements. Anecdotal evidence has indicated that a CRE and a promoter need to be biochemically compatible for promoter regulation to occur, but this...

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Enhancer-promoter communication: unraveling enhancer strength and positioning within a given topologically associating domain (TAD).

Publication Type:Academic Journal

Source(s):Signal transduction and targeted therapy [Signal Transduct Target Ther] 2022 Aug 12; Vol. 7 (1), pp. 281. Date of Electronic Publication: 2022 Aug 12.

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Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions.

Publication Type:Academic Journal

Source(s):Nucleic acids research [Nucleic Acids Res] 2022 Aug 12; Vol. 50 (14), pp. 7842-7855.

Abstract:Nuclease-inactivated CRISPR/Cas-based (dCas-based) systems have emerged as powerful technologies to synthetically reshape the human epigenome and gene expression. Despite the increasing adoption of these platforms, their relative potencies and mechanis...

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Pervasive transcription enhances the accessibility of H-NS-silenced promoters and generates bistability in Salmonella virulence gene expression.

Publication Type:Academic Journal

Source(s):Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jul 26; Vol. 119 (30), pp. e2203011119. Date of Electronic Publication: 2022 Jul 18.

Abstract:In Escherichia coli and Salmonella, many genes silenced by the nucleoid structuring protein H-NS are activated upon inhibiting Rho-dependent transcription termination. This response is poorly understood and difficult to reconcile with the view that H-N...

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Quantitative contribution of the spacer length in the supercoiling-sensitivity of bacterial promoters.

Publication Type:Academic Journal

Source(s):Nucleic acids research [Nucleic Acids Res] 2022 Jul 22; Vol. 50 (13), pp. 7287-7297.

Abstract:DNA supercoiling acts as a global transcriptional regulator in bacteria, but the promoter sequence or structural determinants controlling its effect remain unclear. It was previously proposed to modulate the torsional angle between the -10 and -35 hexa...

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Quantitative parameters of bacterial RNA polymerase open-complex formation, stabilization and disruption on a consensus promoter.

Publication Type:Academic Journal

Source(s):Nucleic acids research [Nucleic Acids Res] 2022 Jul 22; Vol. 50 (13), pp. 7511-7528.

Abstract:Transcription initiation is the first step in gene expression, and is therefore strongly regulated in all domains of life. The RNA polymerase (RNAP) first associates with the initiation factor $\sigma$ to form a holoenzyme, which binds, bends and opens...

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