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The Landmark Series: Intraductal Papillary Mucinous Neoplasms of the Pancreas-From Prevalence to Early Cancer Detection.
Publication Type: Academic Journal
Source(s): Annals of surgical oncology [Ann Surg Oncol] 2023 Mar; Vol. 30 (3), pp. 1453-1462. Date of Electronic Publication: 2023 Jan 04.
Abstract: Modern series report a prevalence of pancreatic cysts in the general population of up to 50% in prospective studies. Of these, about half will be pancreatic cystic neoplasms (PCNs) that have varying degrees of malignant potential. Intraductal papillary...
Genetic Testing Among Patients with High-Risk Breast, Ovarian, Pancreatic, and Prostate Cancers.
Publication Type: Academic Journal
Source(s): Annals of surgical oncology [Ann Surg Oncol] 2023 Mar; Vol. 30 (3), pp. 1312-1326. Date of Electronic Publication: 2022 Nov 05.
Abstract: Background: The National Comprehensive Cancer Network recommends genetic testing in patients with potentially hereditary breast, ovarian, pancreatic, and prostate cancers (HBOPP). Knowledge of genetic mutations impacts decisions about screening and tre...
Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.
Publication Type: Academic Journal
Source(s): Virchows Archiv : an international journal of pathology [Virchows Arch] 2022 Dec; Vol. 481 (6), pp. 865-876. Date of Electronic Publication: 2022 Sep 24.
Abstract: Intraductal oncocytic papillary neoplasms (IOPNs) of the pancreatobiliary system are tumors comprising oncocytic cells, in which three types of fusion genes involving -PRKACA/-PRKACB were recently identified. IOPNs infrequently combine with other histo...
Pancreatic metastasis of malignant melanoma presenting as a tumor occluding the main pancreatic duct.
Publication Type: Academic Journal
Source(s): Clinical journal of gastroenterology [Clin J Gastroenterol] 2022 Oct; Vol. 15 (5), pp. 994-998. Date of Electronic Publication: 2022 Jun 21.
Abstract: Metastasis to the pancreas is rare, especially for malignant melanoma. In these scarce cases, tumors normally present in the parenchyma of the pancreas. A 70-year-old woman was referred to our hospital for an asymptomatic pancreatic tumor detected by c...
ESE3-positive PSCs drive pancreatic cancer fibrosis, chemoresistance and poor prognosis via tumour-stromal IL-1β/NF-κB/ESE3 signalling axis.
Publication Type: Academic Journal
Source(s): British journal of cancer [Br J Cancer] 2022 Nov; Vol. 127 (8), pp. 1461-1472. Date of Electronic Publication: 2022 Aug 19.
Abstract: Background: Desmoplastic stroma, a feature of pancreatic ductal adenocarcinoma (PDAC), contains abundant activated pancreatic stellate cells (PSCs). How PSCs promote PDAC progression remains incompletely understood.Methods: Effect of epithelium-specifi...
Laparoscopic Enucleation of Pancreatic Neoplasms: A Single-Center Experience and Outcomes.
Publication Type: Academic Journal
Source(s): Journal of laparoendoscopic & advanced surgical techniques. Part A [J Laparoendosc Adv Surg Tech A] 2022 Oct; Vol. 32 (10), pp. 1032-1037. Date of Electronic Publication: 2022 Apr 19.
Abstract: Background: Laparoscopic technique has been increasingly applied in the treatment of selected pancreatic tumors. The aim of this study is to evaluate the experience with laparoscopic enucleation of pancreatic neoplasms (LEPNs), for selected pa...
Intraoperative pancreatoscopy in pancreaticoduodenectomy for intraductal papillary mucinous neoplasms of the pancreas: Application to the laparoscopic approach.
Publication Type: Academic Journal
Source(s): Asian journal of surgery [Asian J Surg] 2023 Jan; Vol. 46 (1), pp. 166-173. Date of Electronic Publication: 2022 Mar 21.
Abstract: Background: /Purpose: Owing to the characteristics of IPMNs, which have variable skipped lesions along the main pancreatic duct (MPD), determining the surgical margins is very difficult. This study aimed to investigate the efficacy and potential oncolo...
Simultaneous and sequential combination of genetic and epigenetic biomarkers for the presence of high-grade dysplasia in patients with pancreatic cyst: Discovery in cyst fluid and test in pancreatic juice.
Publication Type: Academic Journal
Source(s): Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] [Pancreatology] 2023 Mar; Vol. 23 (2), pp. 218-226. Date of Electronic Publication: 2023 Jan 13.
Abstract: Background/objectives: Screening patients with intraductal papillary mucinous neoplasms (IPMN) has the primary goal of identifying potentially curable noninvasive precursors. We aimed to evaluate the diagnostic impact of genetic and epigenetic biomarke...
Pharmacological targeting of the receptor ALK inhibits tumorigenicity and overcomes chemoresistance in pancreatic ductal adenocarcinoma.
Publication Type: Academic Journal
Source(s): Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Feb; Vol. 158, pp. 114162. Date of Electronic Publication: 2022 Dec 24.
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease characterized by its metastatic potential and chemoresistance. These traits are partially attributable to the highly tumorigenic pancreatic cancer stem cells (PaCSCs). Interesti...
Diabetes in intraductal papillary mucinous neoplasm of the pancreas and its association with malignancy.
Publication Type: Academic Journal
Source(s): Journal of surgical oncology [J Surg Oncol] 2023 Mar; Vol. 127 (4), pp. 625-632. Date of Electronic Publication: 2022 Nov 21.
Abstract: Background: Intraductal papillary mucinous neoplasms (IPMNs) have the potential to become malignant. Few studies have focused on the prevalence of the diabetes mellitus (DM) in IPMNs and its association with malignancy. We evaluated the association bet...