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Interleukin-1β and plasminogen activating system members in endometriotic stromal cell migration/invasion.
Publication Type: Academic Journal
Source(s): F&S science [F S Sci] 2023 Feb; Vol. 4 (1), pp. 47-55. Date of Electronic Publication: 2022 Sep 21.
Abstract: Objective: To study the role of interleukin (IL)-1β and the plasminogen activating (PA) system members in endometriotic stromal cell (ESC) migration/invasion.Design: Primary cultures of ESCs.Setting: Tertiary referral center for endometriosis and pelvi...
Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study.
Publication Type: Academic Journal
Source(s): Critical care (London, England) [Crit Care] 2023 Feb 10; Vol. 27 (1), pp. 55. Date of Electronic Publication: 2023 Feb 10.
Abstract: Background: Fibrinolysisis is essential for vascular blood flow maintenance and is triggered by endothelial and platelet release of tissue plasminogen activator (t-PA). In certain critical conditions, e.g. sepsis, acute respiratory failure (ARF) and tr...
Glucocorticoid-Responsive Tissue Plasminogen Activator (tPA) and Its Inhibitor Plasminogen Activator Inhibitor-1 (PAI-1): Relevance in Stress-Related Psychiatric Disorders.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Feb 24; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 24.
Abstract: Stressful events trigger a set of complex biological responses which follow a bell-shaped pattern. Low-stress conditions have been shown to elicit beneficial effects, notably on synaptic plasticity together with an increase in cognitive processes. In c...
Urokinase plasminogen activator surface receptor restricts HIV-1 replication by blocking virion release from the cell membrane.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 17; Vol. 120 (3), pp. e2212991120. Date of Electronic Publication: 2023 Jan 13.
Abstract: The urokinase-type plasminogen activator (uPA) system consists of the proteinase uPA, its receptor (PLAUR/uPAR). Under physiological conditions, uPA and PLAUR are predominantly expressed by blood cells, including neutrophils, monocytes, and macrophages...
Angiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Feb 14; Vol. 120 (7), pp. e2214081120. Date of Electronic Publication: 2023 Feb 10.
Abstract: Triglyceride (TG) metabolism is highly regulated by angiopoietin-like protein (ANGPTL) family members [Y. Q. Chen et al. , J. Lipid Res. , 1203-1220 (2020)]. During feeding, ANGPTL8 forms complexes with the fibrinogen-like domain-containing protein AN...
Nafamostat Mesylate in Combination with the Mouse Amino-Terminal Fragment of Urokinase-Human Serum Albumin Improves the Treatment Outcome of Triple-Negative Breast Cancer Therapy.
Publication Type: Academic Journal
Source(s): Molecular pharmaceutics [Mol Pharm] 2023 Feb 06; Vol. 20 (2), pp. 905-917. Date of Electronic Publication: 2022 Dec 04.
Abstract: Triple-negative breast cancer (TNBC) is highly aggressive and causes a higher proportion of metastatic cases. However, therapies directed to specific molecular targets have rarely achieved clinically meaningful improvements in the outcome of TNBC thera...
The Role of the Plasminogen/Plasmin System in Inflammation of the Oral Cavity.
Publication Type: Academic Journal
Source(s): Cells [Cells] 2023 Jan 30; Vol. 12 (3). Date of Electronic Publication: 2023 Jan 30.
Abstract: The oral cavity is a unique environment that consists of teeth surrounded by periodontal tissues, oral mucosae with minor salivary glands, and terminal parts of major salivary glands that open into the oral cavity. The cavity is constantly exposed to v...
[Regional catheter thrombolysis for late proximal deep vein thrombosis].
Publication Type: Academic Journal
Source(s): Khirurgiia [Khirurgiia (Mosk)] 2023 (1), pp. 61-66.
Abstract: Objective: To compare the efficacy of regional catheter thrombolysis with urokinase and alteplase for late proximal deep vein thrombosis.Material and Methods: We analyzed safety and effectiveness of treatment of 38 patients with late proximal deep vein...
uPAR, beyond regulating physiological functions, has orchestrated roles in cancer (Review).
Publication Type: Academic Journal
Source(s): International journal of oncology [Int J Oncol] 2022 Dec; Vol. 61 (6). Date of Electronic Publication: 2022 Oct 20.
Abstract: Urokinase‑type plasminogen activator receptor (uPAR) serves as the receptor for uPA and the uPA‑uPAR complex initiates the extracellular matrix degradation cascade. In cancer, aberrantly elevated uPAR expression is associated with invasion and metastas...