Advanced Search Results For "Plasminogen genetics"
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Interleukin-1β and plasminogen activating system members in endometriotic stromal cell migration/invasion.
Publication Type: Academic Journal
Source(s): F&S science [F S Sci] 2023 Feb; Vol. 4 (1), pp. 47-55. Date of Electronic Publication: 2022 Sep 21.
Abstract: Objective: To study the role of interleukin (IL)-1β and the plasminogen activating (PA) system members in endometriotic stromal cell (ESC) migration/invasion.Design: Primary cultures of ESCs.Setting: Tertiary referral center for endometriosis and pelvi...
Urokinase plasminogen activator surface receptor restricts HIV-1 replication by blocking virion release from the cell membrane.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 17; Vol. 120 (3), pp. e2212991120. Date of Electronic Publication: 2023 Jan 13.
Abstract: The urokinase-type plasminogen activator (uPA) system consists of the proteinase uPA, its receptor (PLAUR/uPAR). Under physiological conditions, uPA and PLAUR are predominantly expressed by blood cells, including neutrophils, monocytes, and macrophages...
Plasminogen Activator Inhibitor-1 Polymorphisms and Risk of Coronary Artery Disease: Evidence From Meta-Analysis and Trial Sequential Analysis.
Publication Type: Academic Journal
Source(s): Biochemical genetics [Biochem Genet] 2022 Oct; Vol. 60 (5), pp. 1409-1445. Date of Electronic Publication: 2022 Jan 18.
Abstract: A systematic review and meta-analysis were conducted to find out if there was association between Plasminogen Activator Inhibitor-1 (PAI-1) gene polymorphisms (- 844 G > A and - 675 4G > 5G) and susceptibility to coronary artery disease (CAD). Search o...
TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR.
Publication Type: Academic Journal
Source(s): International journal of biological sciences [Int J Biol Sci] 2022 Jul 11; Vol. 18 (11), pp. 4560-4577. Date of Electronic Publication: 2022 Jul 11 (Print Publication: 2022).
Abstract: Gastric cancer (GC) is the most common gastrointestinal malignant tumor, and distant metastasis is a critical factor in the prognosis of patients with GC. Understanding the mechanism of GC metastasis will help improve patient prognosis. Studies have co...
PLAU is associated with cell migration and invasion and is regulated by transcription factor YY1 in cervical cancer.
Publication Type: Academic Journal
Source(s): Oncology reports [Oncol Rep] 2023 Feb; Vol. 49 (2). Date of Electronic Publication: 2022 Dec 16.
Abstract: Cervical cancer, one of the most common malignancies, has a poor survival rate. The identification of more biomarkers for cervical cancer diagnosis and therapy is urgently needed. Plasminogen activator urokinase (PLAU) exerts multiple biological effect...
Association between plasminogen activator inhibitor-1 gene polymorphisms and susceptibility to Parkinson's disease in Chinese patients.
Publication Type: Academic Journal
Source(s): Acta neurologica Belgica [Acta Neurol Belg] 2022 Dec; Vol. 122 (6), pp. 1557-1566. Date of Electronic Publication: 2021 Nov 29.
Abstract: Purpose: Parkinson's disease (PD) is a neurodegenerative disease that usually leads to memory impairment, cognitive decline and dementia. Previous studies have reported that plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms play important ro...
Angiogenetic transcriptional profiling reveals potential targets modulated in blood of patients with cardiovascular disorders.
Publication Type: Academic Journal
Source(s): Vascular [Vascular] 2023 Feb; Vol. 31 (1), pp. 152-162. Date of Electronic Publication: 2021 Nov 24.
Abstract: Objectives: Based on the angiogenetic, transcriptional profile of non-diseased and arteriosclerotic vessels, we aim to identify the leucocytic markers as a potential, minimal invasive tool supporting diagnosis of vascular pathology.Methods: Transcripti...
Proteomics analysis uncovers plasminogen activator PLAU as a target of the STING pathway for suppression of cancer cell migration and invasion.
Publication Type: Academic Journal
Source(s): The Journal of biological chemistry [J Biol Chem] 2023 Jan; Vol. 299 (1), pp. 102779. Date of Electronic Publication: 2022 Dec 07.
Abstract: The stimulator of interferon genes (STING) pathway is vital for immune defense against pathogen invasion and cancer. Although ample evidence substantiates that the STING signaling pathway plays an essential role in various cancers via cytokines, no com...
In situ hybridization for the assessment of urokinase plasminogen activator and plasminogen activator inhibitor type‑1 in formalin‑fixed paraffin‑embedded breast cancer specimens.
Publication Type: Academic Journal
Source(s): International journal of molecular medicine [Int J Mol Med] 2022 Jun; Vol. 49 (6). Date of Electronic Publication: 2022 Apr 27.
Abstract: Urokinase plasminogen activator (uPA) and its inhibitor, plasminogen activator inhibitor type 1 (PAI‑1), have been reported as prognostic and predictive biomarkers in breast cancer, particularly in patients with node‑negative tumors. uPA and PAI‑1 expr...
uPAR, beyond regulating physiological functions, has orchestrated roles in cancer (Review).
Publication Type: Academic Journal
Source(s): International journal of oncology [Int J Oncol] 2022 Dec; Vol. 61 (6). Date of Electronic Publication: 2022 Oct 20.
Abstract: Urokinase‑type plasminogen activator receptor (uPAR) serves as the receptor for uPA and the uPA‑uPAR complex initiates the extracellular matrix degradation cascade. In cancer, aberrantly elevated uPAR expression is associated with invasion and metastas...