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Surface Modification of lactose carrier particles using a fluid bed coater to improve fine particle fraction for dry powder inhalers.
Publication Type: Academic Journal
Source(s): Pharmaceutical development and technology [Pharm Dev Technol] 2023 Feb; Vol. 28 (2), pp. 164-175. Date of Electronic Publication: 2023 Jan 26.
Abstract: Surface roughness of carrier particles can impact dry powder inhaler (DPI) performance. There are opposing views on the effect of roughness on DPI performance. Hence, a systematic approach is needed to modify carrier surfaces and evaluate the impact on...
Quantifying Agglomerate-to-Wall Impaction in Dry Powder Inhalers.
Publication Type: Academic Journal
Source(s): Pharmaceutical research [Pharm Res] 2023 Jan; Vol. 40 (1), pp. 307-319. Date of Electronic Publication: 2022 Dec 05.
Abstract: Purpose: The probability of agglomerate-to-wall collision was quantified using a unique image processing technique applied to high-speed microscopic images. The study aimed to investigate the effects of flow rate and particle size on the percentage of ...
Nanoparticle-containing lyophilized dry powder inhaler formulations optimized using central composite design with improved aerodynamic parameters and redispersibility.
Publication Type: Academic Journal
Source(s): Pharmaceutical development and technology [Pharm Dev Technol] 2023 Jan; Vol. 28 (1), pp. 124-137. Date of Electronic Publication: 2023 Jan 12.
Abstract: Objectives: The aim of this study was to improve the aerodynamic behavior and redispersibility of a lyophilized dry powder inhaler (DPI) formulation containing nanoparticles. Methods: Paclitaxel (PTX)-human serum albumin (HSA) nanoparticles were used a...
Effect of Texture and Surface Chemistry on Deagglomeration and Powder Retention in Capsule-Based Dry Powder Inhaler.
Publication Type: Academic Journal
Source(s): AAPS PharmSciTech [AAPS PharmSciTech] 2022 Oct 14; Vol. 23 (7), pp. 281. Date of Electronic Publication: 2022 Oct 14.
Abstract: Pulmonary delivery systems should administer a high dose of the required formulation with the designated dry powder inhaler (DPI) to achieve therapeutic success. While the effects of device geometry and individual components used on powder dispersion a...
Pharmaceutical dry powders of small molecules prepared by thin-film freezing and their applications - A focus on the physical and aerosol properties of the powders.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2022 Dec 15; Vol. 629, pp. 122357. Date of Electronic Publication: 2022 Nov 01.
Abstract: Thin-film freeze-drying is a dry powder engineering technology that involves in a rapid thin-film freezing (TFF) process followed by lyophilization to remove solvent. TFF process has been successfully used to produce pharmaceutical powders of the small...
Advancements in Particle Engineering for Inhalation Delivery of Small Molecules and Biotherapeutics.
Publication Type: Academic Journal
Source(s): Pharmaceutical research [Pharm Res] 2022 Dec; Vol. 39 (12), pp. 3047-3061. Date of Electronic Publication: 2022 Sep 07.
Abstract: Dry powder inhalation formulations have become increasingly popular for local and systemic delivery of small molecules and biotherapeutics. Powder formulations provide distinct advantages over liquid formulations such as elimination of cold chain due t...
The effects of grid design on the performance of 3D-printed dry powder inhalers.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2022 Nov 05; Vol. 627, pp. 122230. Date of Electronic Publication: 2022 Sep 23.
Abstract: The grid structure is an indispensable part of most dry powder inhalers, but the effects of grid geometry on inhaler performance are rarely reported. This study aims to systemically investigate the influence of grid design on the aerosolization perform...
Scientific and regulatory activities initiated by the U.S. Food and drug administration to foster approvals of generic dry powder inhalers: Bioequivalence perspective.
Publication Type: Academic Journal
Source(s): Advanced drug delivery reviews [Adv Drug Deliv Rev] 2022 Nov; Vol. 190, pp. 114526. Date of Electronic Publication: 2022 Sep 05.
Abstract: Regulatory science for generic dry powder inhalers (DPIs) in the United States (U.S.) has evolved over the last decade. In 2013, the U.S. Food and Drug Administration (FDA) published the draft product-specific guidance (PSG) for fluticasone propionate ...
The applications of Machine learning (ML) in designing dry powder for inhalation by using thin-film-freezing technology.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2022 Oct 15; Vol. 626, pp. 122179. Date of Electronic Publication: 2022 Sep 07.
Abstract: Dry powder inhalers (DPIs) are one of the most widely used devices for treating respiratory diseases. Thin--film--freezing (TFF) is a particle engineering technology that has been demonstrated to prepare dry powder for inhalation with enhanced physicoc...
Solid state of inhalable high dose powders.
Publication Type: Academic Journal
Source(s): Advanced drug delivery reviews [Adv Drug Deliv Rev] 2022 Oct; Vol. 189, pp. 114468. Date of Electronic Publication: 2022 Jul 30.
Abstract: High dose inhaled powders have received increased attention for treating lung infections. These powders can be prepared using techniques such as spray drying, spray-freeze drying, crystallization, and milling. The selected preparation technique is know...