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Advanced Search Results For "RABIES"

1 - 10 of 25,056 results for
 "RABIES"
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Safety and immunogenicity of a serum-free purified Vero rabies vaccine in healthy adults: A randomised phase II pre-exposure prophylaxis study.

Publication Type:Academic Journal

Source(s):Vaccine [Vaccine] 2022 Aug 05; Vol. 40 (33), pp. 4780-4787. Date of Electronic Publication: 2022 Jun 28.

Abstract:A serum-free, highly purified Vero cell rabies vaccine (PVRV-NG) is under development. We previously demonstrated that pre-exposure prophylaxis (PrEP) with PVRV-NG had a satisfactory safety profile and was immunogenically non-inferior to the licensed p...

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Commentary on the implications of safety and efficacy studies in pediatric patients with administration of human rabies immune globulin (HRIG)?

Publication Type:Academic Journal

Source(s):Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2022 Nov 30; Vol. 18 (5), pp. 2054262. Date of Electronic Publication: 2022 Apr 19.

Abstract:The FDA strongly encourages rigorous safety and efficacy studies in all age groups for which vaccines and treatments for pervasive and severe diseases are intended. Until recently, there had been no safety and efficacy studies conducted in children for...

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Rabies Elimination in Rural Kenya: Need for Improved Availability of Human Vaccines, Awareness and Knowledge on Rabies and Its Management Among Healthcare Workers.

Publication Type:Academic Journal

Source(s):Frontiers in public health [Front Public Health] 2022 Mar 10; Vol. 10, pp. 769898. Date of Electronic Publication: 2022 Mar 10 (Print Publication: 2022).

Abstract:Background: In Africa, rabies causes an estimated 24,000 human deaths annually. Mass dog vaccinations coupled with timely post-exposure prophylaxis (PEP) for dog-bite patients are the main interventions to eliminate human rabies deaths. A well-informed...

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Lab-Attenuated Rabies Virus Facilitates Opening of the Blood-Brain Barrier by Inducing Matrix Metallopeptidase 8.

Publication Type:Academic Journal

Source(s):Journal of virology [J Virol] 2022 Sep 14; Vol. 96 (17), pp. e0105022. Date of Electronic Publication: 2022 Aug 25.

Abstract:Infection with laboratory-attenuated rabies virus (RABV), but not wild-type (wt) RABV, can enhance the permeability of the blood-brain barrier (BBB), which is considered a key determinant for RABV pathogenicity. A previous study showed that the enhance...

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Notes from the Field: Three Human Rabies Deaths Attributed to Bat Exposures - United States, August 2021.

Publication Type:Academic Journal

Source(s):MMWR. Morbidity and mortality weekly report [MMWR Morb Mortal Wkly Rep] 2022 Jan 07; Vol. 71 (1), pp. 31-32. Date of Electronic Publication: 2022 Jan 07.

Abstract:Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed.

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Who let the dogs In? An epidemiological study quantifying domestically sourced and imported dogs in Southern Ontario, Canada.

Publication Type:Academic Journal

Source(s):Zoonoses and public health [Zoonoses Public Health] 2021 Sep; Vol. 68 (6), pp. 588-600. Date of Electronic Publication: 2021 May 14.

Abstract:Dogs are reservoirs for many zoonoses. In southern Ontario, Canada, minimal data exist on the sources from which domestic dogs are acquired (i.e., domestic or imported). The objectives of this study were to (1) describe the proportions of domestically ...

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Rabies virus infection is associated with alterations in the expression of parvalbumin and secretagogin in mice brain.

Publication Type:Academic Journal

Source(s):Metabolic brain disease [Metab Brain Dis] 2021 Aug; Vol. 36 (6), pp. 1267-1275. Date of Electronic Publication: 2021 Mar 30.

Abstract:Infection with the deadly rabies virus (RABV) leads to alteration of cellular gene expression. The RABV, similar to other neurodegenerative diseases may be implicated in neuronal death due to an imbalance in Ca 2+ homeostasis. Parvalbumin (PV) and Secr...

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Enhancement of immune responses by co-stimulation of TLR3 - TLR7 agonists as a potential therapeutics against rabies in mouse model.

Publication Type:Academic Journal

Source(s):Microbial pathogenesis [Microb Pathog] 2021 Aug; Vol. 157, pp. 104971. Date of Electronic Publication: 2021 May 21.

Abstract:Rabies is always fatal, when post-exposure prophylaxis is administered after the onset of clinical symptoms. To date, there is no effective treatment of rabies once clinical symptoms has initiated. Therefore, we aimed to provide evidences which indicat...

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Safety and immunogenicity of SURE RAB™, an inactivated cell culture derived rabies vaccine: A comparative, phase III clinical trial.

Publication Type:Academic Journal

Source(s):Indian journal of medical microbiology [Indian J Med Microbiol] 2021 Jan; Vol. 39 (1), pp. 63-66. Date of Electronic Publication: 2021 Jan 12.

Abstract:Introduction: Rabies is a viral zoonotic disease widespread across the world. In India, various cell culture vaccines are available for pre and post exposure prophylaxis (PEP) but are not sufficient to meet the rising demand. The present study evaluate...

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Rabies Virus Neutralizing Activity, Safety, and Immunogenicity of Recombinant Human Rabies Antibody Compared with Human Rabies Immunoglobulin in Healthy Adults.

Publication Type:Academic Journal

Source(s):Biomedical and environmental sciences : BES [Biomed Environ Sci] 2022 Sep 20; Vol. 35 (9), pp. 782-791.

Abstract:Objective: Preliminary assessment of rabies virus neutralizing activity, safety and immunogenicity of a recombinant human rabies antibody (NM57) compared with human rabies immunoglobulin (HRIG) in Chinese healthy adults.Methods: Subjects were randomly ...

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