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Advanced Search Results For "RANDOMIZED controlled trials"

1 - 10 of 397,361 results for
 "RANDOMIZED controlled trials"
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Combining individual patient data from randomized and non-randomized studies to predict real-world effectiveness of interventions.

Publication Type:Academic Journal

Source(s):Statistical methods in medical research [Stat Methods Med Res] 2022 Jul; Vol. 31 (7), pp. 1355-1373. Date of Electronic Publication: 2022 Apr 26.

Abstract:Meta-analysis of randomized controlled trials is generally considered the most reliable source of estimates of relative treatment effects. However, in the last few years, there has been interest in using non-randomized studies to complement evidence fr...

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Critical Care Randomized Trials Demonstrate Power Failure: A Low Positive Predictive Value of Findings in the Critical Care Research Field.

Publication Type:Academic Journal

Source(s):Journal of intensive care medicine [J Intensive Care Med] 2022 Aug; Vol. 37 (8), pp. 1082-1093. Date of Electronic Publication: 2022 Feb 18.

Abstract:Background: We aimed to determine the post-hoc power of randomized controlled trials (RCTs) in critical care, and describe the implications for long-term positive (PPV) and negative predictive value (NPV) of statistically significant and non-significan...

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Access to unpublished protocols and statistical analysis plans of randomised trials.

Publication Type:Academic Journal

Source(s):Trials [Trials] 2022 Aug 17; Vol. 23 (1), pp. 674. Date of Electronic Publication: 2022 Aug 17.

Abstract:Background: Access to protocols and statistical analysis plans (SAPs) increases the transparency of randomised trial by allowing readers to identify and interpret unplanned changes to study methods, however they are often not made publicly available. W...

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Are longitudinal randomised controlled oral health trials properly analysed? A meta-epidemiological study.

Publication Type:Academic Journal

Source(s):Journal of dentistry [J Dent] 2022 Sep; Vol. 124, pp. 104182. Date of Electronic Publication: 2022 Jun 09.

Abstract:Introduction: Longitudinal designs with multiple outcome measurements are commonly encountered in oral health randomised controlled trials (RCTs). The aim of this meta epidemiological study was to assess whether optimal statistical analysis approaches ...

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The proportion of randomized controlled trials that inform clinical practice.

Publication Type:Academic Journal

Source(s):ELife [Elife] 2022 Aug 17; Vol. 11. Date of Electronic Publication: 2022 Aug 17.

Abstract:Prior studies suggest that clinical trials are often hampered by problems in design, conduct, and reporting that limit their uptake in clinical practice. We have described 'informativeness' as the ability of a trial to guide clinical, policy, or resear...

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Cluster randomised trials with a binary outcome and a small number of clusters: comparison of individual and cluster level analysis method.

Publication Type:Academic Journal

Source(s):BMC medical research methodology [BMC Med Res Methodol] 2022 Aug 12; Vol. 22 (1), pp. 222. Date of Electronic Publication: 2022 Aug 12.

Abstract:Background: Cluster randomised trials (CRTs) are often designed with a small number of clusters, but it is not clear which analysis methods are optimal when the outcome is binary. This simulation study aimed to determine (i) whether cluster-level analy...

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Trials and Tribulations of Randomized Clinical Trials.

Publication Type:Editorial & Opinion

Source(s):Circulation [Circulation] 2022 Aug 02; Vol. 146 (5), pp. 380-382. Date of Electronic Publication: 2022 Jul 01.

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Design and analysis of partially randomized preference trials with propensity score stratification.

Publication Type:Academic Journal

Source(s):Statistical methods in medical research [Stat Methods Med Res] 2022 Aug; Vol. 31 (8), pp. 1515-1537. Date of Electronic Publication: 2022 Apr 26.

Abstract:While the two-stage randomized design allows us to unbiasedly evaluate the impact of patients' treatment preference on the outcome of interest, it may not always be practical to implement in clinical practice; patients with a strong preference may not ...

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The Effects of Foam Rolling Training on Performance Parameters: A Systematic Review and Meta-Analysis including Controlled and Randomized Controlled Trials.

Publication Type:Academic Journal

Source(s):International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Sep 15; Vol. 19 (18). Date of Electronic Publication: 2022 Sep 15.

Abstract:Foam rolling (FR) is a new and popular technique for increasing range of motion. While there are a few studies that demonstrate increased performance measures after an acute bout of FR, the overall evidence indicates trivial performance benefits. As th...

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Re-analysis on the statistical sampling biases of a mask promotion trial in Bangladesh: a statistical replication.

Publication Type:Editorial & Opinion

Source(s):Trials [Trials] 2022 Sep 15; Vol. 23 (1), pp. 786. Date of Electronic Publication: 2022 Sep 15.

Abstract:A recent randomized trial evaluated the impact of mask promotion on COVID-19-related outcomes. We find that staff behavior in both unblinded and supposedly blinded steps caused large and statistically significant imbalances in population sizes. These d...

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