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Advanced Search Results For "RELEVANCE"

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Setting course for a translational pharmacology and a predictive toxicology based on the numerical probability of clinical relevance.

Publication Type: Academic Journal

Source(s): Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2023 Jan; Vol. 97, pp. 103968. Date of Electronic Publication: 2022 Sep 06.

Abstract: For a significant share of the chemicals, current bioassays mispredicted the outcomes in the reference methods they simulate. For any drug or chemical, and depending on the regulatory or corporate situation, three different approaches calculate the num...

A universal and sensitive gene mutation detection method based on CRISPR-Cas12a.

Publication Type: Academic Journal

Source(s): Analytica chimica acta [Anal Chim Acta] 2023 Mar 15; Vol. 1246, pp. 340886. Date of Electronic Publication: 2023 Jan 23.


Abstract: Single nucleotide mutations are highly related to the occurrence and development of cancer. The development of simple single nucleotide mutation detection methods with high sensitivity and specificity has great clinical significance for the prevention,...

Expression of HIF-1α/PKM2 axis correlates to biological and clinical significance in papillary thyroid carcinoma.

Publication Type: Academic Journal

Source(s): Medicine [Medicine (Baltimore)] 2023 Mar 10; Vol. 102 (10), pp. e33232.


Abstract: hypoxia inducible factor-1α (HIF-1α) and pyruvate kinase M2 (PKM2) are 2 key metabolic regulatory proteins, they could engage in a positive feedback loop and drive cancer growth by enhancing glycolysis. This study aimed to investigate the expression of...

Tracking clusters of patients over time enables extracting information from medico-administrative databases.

Publication Type: Academic Journal

Source(s): Journal of biomedical informatics [J Biomed Inform] 2023 Mar; Vol. 139, pp. 104309. Date of Electronic Publication: 2023 Feb 14.

Abstract: Context: Identifying clusters (i.e., subgroups) of patients from the analysis of medico-administrative databases is particularly important to better understand disease heterogeneity. However, these databases contain different types of longitudinal vari...

Comparability of C-Peptide Measurements - Current Status and Clinical Relevance.

Publication Type: Academic Journal

Source(s): Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association [Exp Clin Endocrinol Diabetes] 2023 Mar; Vol. 131 (3), pp. 173-178. Date of Electronic Publication: 2023 Jan 11.

Abstract: C-peptide is an increasingly used and established marker for beta cell function by assessing endogenous insulin secretion. Accurate and comparable C-peptide measurements are needed in clinical practice and research studies. For example, to calculate HO...

Clinical Significance of Preoperative and Postoperative Serum CEA and Carbohydrate Antigen 19-9 Levels in Patients Undergoing Curative Resection of Locally Recurrent Rectal Cancer.

Publication Type: Academic Journal

Source(s): Diseases of the colon and rectum [Dis Colon Rectum] 2023 Mar 01; Vol. 66 (3), pp. 392-400. Date of Electronic Publication: 2022 Dec 12.

Abstract: Background: Local recurrence is common after curative resection for rectal cancer. Although one expects radical resection of locally recurrent rectal cancer to be curative, the postoperative re-recurrence rate is relatively high. Therefore, identifying...

Genetic prevalence and clinical relevance of canine Mendelian disease variants in over one million dogs.

Publication Type: Academic Journal

Source(s): PLoS genetics [PLoS Genet] 2023 Feb 27; Vol. 19 (2), pp. e1010651. Date of Electronic Publication: 2023 Feb 27 (Print Publication: 2023).

Abstract: Hundreds of genetic variants implicated in Mendelian disease have been characterized in dogs and commercial screening is being offered for most of them worldwide. There is typically limited information available regarding the broader population frequen...

Licensed Content

Publication Type: Academic Journal

Source(s): Ugeskrift for laeger [Ugeskr Laeger] 2023 Feb 13; Vol. 185 (7).

Abstract: Magnetic resonance imaging (MRI) is commonly used in the management of low back pain (LBP). This review provides an overview of the clinical relevance of degenerative MRI findings in the lumbar spine. The association between degenerative MRI findings a...

Clinical relevance of leukocyte-associated endotoxins measured by semi-automatic synthetic luminescent substrate method.

Publication Type: Academic Journal

Source(s): Scientific reports [Sci Rep] 2023 Feb 03; Vol. 13 (1), pp. 1963. Date of Electronic Publication: 2023 Feb 03.

Abstract: A newly developed semi-automatic synthetic luminescence substrate (SALS) method for measuring endotoxin was compared with the existing turbidimetric kinetic assay (TKA) using leukocyte-rich plasma to verify its usefulness. As a result, the endotoxin le...

Preoperative coagulation screening tests in pediatric patients: Clinical relevance and hemorrhagic outcomes of abnormal results.

Publication Type: Academic Journal

Source(s): Revista espanola de anestesiologia y reanimacion [Rev Esp Anestesiol Reanim (Engl Ed)] 2023 Feb; Vol. 70 (2), pp. 68-76. Date of Electronic Publication: 2023 Feb 20.

Abstract: Purpose: Coagulation screening tests in children are still frequently performed in many countries to evaluate bleeding risk. The aim of this study was to assess the management of unexpected prolongations of the activated partial thromboplastin time (AP...