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Critical role for ribonucleoside-diphosphate reductase subunit M2 in ALV-J-induced activation of Wnt/β-catenin signaling via interaction with P27.
Publication Type: Academic Journal
Source(s): Journal of virology [J Virol] 2023 Aug 31; Vol. 97 (8), pp. e0026723. Date of Electronic Publication: 2023 Aug 15.
Abstract: Avian leukemia virus subgroup J (ALV-J) causes various diseases associated with tumor formation and decreased fertility and induced immunosuppressive disease, resulting in significant economic losses in the poultry industry globally. Virus usually expl...
A missense mutation in RRM1 contributes to animal tameness.
Publication Type: Academic Journal
Source(s): Science advances [Sci Adv] 2023 Jun 23; Vol. 9 (25), pp. eadf4068. Date of Electronic Publication: 2023 Jun 23.
Abstract: The increased tameness to reduce avoidance of human in wild animals has been long proposed as the key step of animal domestication. The tameness is a complex behavior trait and largely determined by genetic factors. However, the underlying genetic muta...
RRM1 is mediated by histone acetylation through gemcitabine resistance and contributes to invasiveness and ECM remodeling in pancreatic cancer.
Publication Type: Academic Journal
Source(s): International journal of oncology [Int J Oncol] 2023 Apr; Vol. 62 (4). Date of Electronic Publication: 2023 Mar 03.
Abstract: The invasiveness of pancreatic cancer and its resistance to anticancer drugs define its malignant potential, and are considered to affect the peritumoral microenvironment. Cancer cells with resistance to gemcitabine exposed to external signals induced ...
Prognostic and Immunological Potential of Ribonucleotide Reductase Subunits in Liver Cancer.
Publication Type: Academic Journal
Source(s): Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2023 Jan 20; Vol. 2023, pp. 3878796. Date of Electronic Publication: 2023 Jan 20 (Print Publication: 2023).
Abstract: Background: Ribonucleotide reductase (RR) consists of two subunits, the large subunit RRM1 and the small subunit (RRM2 or RRM2B), which is essential for DNA replication. Dysregulations of RR were implicated in multiple types of cancer. However, the abn...
Circ_0008285 knockdown represses tumor development by miR-384/RRM2 axis in hepatocellular carcinoma.
Publication Type: Academic Journal
Source(s): Annals of hepatology [Ann Hepatol] 2022 Nov-Dec; Vol. 27 (6), pp. 100743. Date of Electronic Publication: 2022 Aug 11.
Abstract: Introduction and Objectives: Circular RNA (circRNA) has attracted extensive attention in studies related to the malignant progression of cancer, including hepatocellular carcinoma (HCC). Therefore, its molecular mechanism in HCC needs to be further exp...
Hepatitis C Virus Down-Regulates the Expression of Ribonucleotide Reductases to Promote Its Replication.
Publication Type: Academic Journal
Source(s): Pathogens. Jul2023, Vol. 12 Issue 7, p892. 14p.
Abstract: Ribonucleotide reductases (RRs or RNRs) catalyze the reduction of the OH group on the 2nd carbon of ribose, reducing four ribonucleotides (NTPs) to the corresponding deoxyribonucleotides (dNTPs) to promote DNA synthesis. Large DNA viruses, such as herp...
ARID1A promotes chemosensitivity to gemcitabine in pancreatic cancer through epigenetic silencing of RRM2.
Publication Type: Academic Journal
Source(s): Die Pharmazie [Pharmazie] 2022 Sep 01; Vol. 77 (7), pp. 224-229.
Abstract: Pancreatic cancer is one of the most common malignancies with very poor prognosis due to its broad resistance to chemotherapy. ARID1A, a subunit of SWI/SNF complex, is involved in pancreatic carcinogenesis through epigenetic silencing of oncogenes. In ...
Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC.
Publication Type: Academic Journal
Source(s): Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2022 Sep; Vol. 171, pp. 103-114. Date of Electronic Publication: 2022 Jul 25.
Abstract: Introduction: Echinoderm microtubule-associated protein-like 4 (EML4)-Anaplastic Lymphoma Kinase (ALK) rearrangements occur in 3% to 7% of lung adenocarcinomas and are targets for treatment with tyrosine kinase inhibitors (TKIs). Here we have developed...
LncRNA PART1 Stimulates the Development of Ovarian Cancer by Up-regulating RACGAP1 and RRM2.
Publication Type: Academic Journal
Source(s): Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2022 Aug; Vol. 29 (8), pp. 2224-2235. Date of Electronic Publication: 2022 May 12.
Abstract: Ovarian cancer (OC) is a kind of gynecologic malignancy with a high mortality rate. Long non-coding RNAs (lncRNAs) have been reported to exert regulatory roles in multiple diseases. However, the role of lncRNA prostate androgen-regulated transcript 1 (...
Ribonucleotide reductase subunit M2 is a potential prognostic marker and therapeutic target for soft tissue sarcoma.
Publication Type: Academic Journal
Source(s): Gene [Gene] 2022 Jan 15; Vol. 808, pp. 145988. Date of Electronic Publication: 2021 Oct 05.
Abstract: Soft tissue sarcomas (STSs) are highly aggressive malignant tumors that exhibit poor therapeutic outcomes. Hence, we aimed to track down a potential gene that can be used as a prognostic marker and therapeutic target for this malignancy. We integrated ...