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Advanced Search Results For "RNA"

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 "RNA"
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RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells.

Publication Type: Academic Journal

Source(s): The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102184. Date of Electronic Publication: 2022 Jun 23.

Abstract: Multidrug resistance-associated protein 4 (MRP4), a member of the C subfamily of ATP-binding cassette transporters, is highly expressed in the kidneys of mammals and is responsible for renal elimination of numerous drugs. Adenosine deaminase acting on ...

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NF90 interacts with components of RISC and modulates association of Ago2 with mRNA.

Publication Type: Academic Journal

Source(s): BMC biology [BMC Biol] 2022 Sep 01; Vol. 20 (1), pp. 194. Date of Electronic Publication: 2022 Sep 01.

Abstract: Background: Nuclear factor 90 (NF90) is a double-stranded RNA-binding protein involved in a multitude of different cellular mechanisms such as transcription, translation, viral infection, and mRNA stability. Recent data suggest that NF90 might influenc...

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Methylation guide RNAs without box C/D motifs.

Publication Type: Academic Journal

Source(s): RNA (New York, N.Y.) [RNA] 2022 Dec; Vol. 28 (12), pp. 1597-1605. Date of Electronic Publication: 2022 Sep 20.

Authors:

Abstract: Box C/D RNAs guide site-specific 2'-O-methylation of RNAs in archaea and eukaryotes. The defining feature of methylation guide RNAs is two sets of box C and D motifs that form kink-turn structures specifically recognized by L7Ae family proteins. Here, ...

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The m 6 A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway.

Publication Type: Academic Journal

Source(s): Molecular cancer [Mol Cancer] 2022 Sep 02; Vol. 21 (1), pp. 174. Date of Electronic Publication: 2022 Sep 02.

Authors:

Abstract: Background: Chemoresistance is a major factor contributing to the poor prognosis of patients with pancreatic cancer, and cancer stemness is one of the most crucial factors associated with chemoresistance and a very promising direction for cancer treatm...

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YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.

Publication Type: Academic Journal

Source(s): ACS chemical biology [ACS Chem Biol] 2022 Jul 15; Vol. 17 (7), pp. 1778-1788. Date of Electronic Publication: 2022 Jun 15.

Authors:

Abstract: Oxaliplatin, as a first-line drug, frequently causes chemo-resistance in colorectal cancer (CRC). The role of N6-methyladenosine (m6A) modification in multiple biological functions has been well studied. However, the molecular mechanisms underlying m6A...

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Construction of a Versatile, Programmable RNA-Binding Protein Using Designer PPR Proteins and Its Application for Splicing Control in Mammalian Cells.

Publication Type: Academic Journal

Source(s): Cells [Cells] 2022 Nov 08; Vol. 11 (22). Date of Electronic Publication: 2022 Nov 08.

Abstract: RNAs play many essential roles in gene expression and are involved in various human diseases. Although genome editing technologies have been established, the engineering of sequence-specific RNA-binding proteins that manipulate particular cellular RNA ...

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Sequestering the 5'-cap for viral RNA packaging.

Publication Type: Academic Journal

Source(s): BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2022 Nov; Vol. 44 (11), pp. e2200104. Date of Electronic Publication: 2022 Sep 13.

Authors:

Abstract: Many viruses evolved mechanisms for capping the 5'-ends of their plus-strand RNAs as a means of hijacking the eukaryotic messenger RNA (mRNA) splicing/translation machinery. Although capping is critical for replication, the RNAs of these viruses have o...

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RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer.

Publication Type: Academic Journal

Source(s): Seminars in cancer biology [Semin Cancer Biol] 2022 Nov; Vol. 86 (Pt 2), pp. 664-677. Date of Electronic Publication: 2022 Apr 02.

Authors:

Abstract: RNA-binding proteins (RBPs) are key players in cellular physiology through posttranscriptional regulation of the expression of target RNA transcripts. By modulating the processing, stability and translation of cancer-related messenger RNA (mRNA) transc...

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How RNA editing keeps an I on physiology.

Publication Type: Academic Journal

Source(s): American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2022 Nov 01; Vol. 323 (5), pp. C1496-C1511. Date of Electronic Publication: 2022 Aug 29.

Abstract: Adenosine deaminases acting on RNAs convert adenosines (A) to inosines (I) in structured or double-stranded RNAs. In mammals, this process is widespread. In the human transcriptome, more than a million different sites have been identified that undergo ...

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Exploring the epitranscriptome by native RNA sequencing.

Publication Type: Academic Journal

Source(s): RNA (New York, N.Y.) [RNA] 2022 Nov; Vol. 28 (11), pp. 1430-1439. Date of Electronic Publication: 2022 Sep 14.

Abstract: Chemical RNA modifications, collectively referred to as the "epitranscriptome," are essential players in fine-tuning gene expression. Our ability to analyze RNA modifications has improved rapidly in recent years, largely due to the advent of high-throu...

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