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Unmasking the Warburg Effect: Unleashing the Power of Enzyme Inhibitors for Cancer Therapy
Publication Type: Academic Journal
Source(s): Drugs and Drug Candidates, Vol 2, Iss 37, Pp 728-769 (2023)
Abstract: The Warburg effect (or aerobic glycolysis), which was first described in 1926 by Otto Heinrich Warburg, consists of the change in glucose metabolism in cancer cells. In normal cells, glucose metabolism finalizes in the mitochondria through oxidative ph...
Preformulation Studies of Novel Menthol Prodrugs with Antiparasitic Activity: Chemical Stability, In Silico, and In Vitro Permeability Assays
Publication Type: Academic Journal
Source(s): Drugs and Drug Candidates, Vol 2, Iss 38, Pp 770-780 (2023)
Abstract: Based on the demonstrated and reported trypanocidal, leishmanicidal, and antiplasmodial activities of two menthol prodrugs, it was decided to proceed with preformulation studies, which are of key relevance in the drug discovery process. The aim of this...
Bradykinin-Mediated Angioedema Induced by Commonly Used Cardiovascular Drugs
Publication Type: Academic Journal
Source(s): Drugs and Drug Candidates, Vol 2, Iss 36, Pp 708-727 (2023)
Abstract: ACE inhibitors, sartans, and sacubitril are among the most important drugs for the prevention of cardiovascular mortality and morbidity. At the same time, they are known to cause non-allergic bradykinin-mediated angioedema, a potentially fatal swelling...
Immune response – genesis, duration, and strength in patients with moderate and severe coronavirus infection of different age groups
Publication Type: Academic Journal
Source(s): Pharmacia, Vol 70, Iss 4, Pp 853-865 (2023)
Abstract: Acquired (adaptive) immunity is a major factor determining effective immune response against a few infectious diseases. The immune response during recovery from COVID-19 is complex, involving both cellular and humoral adaptive immunity. The purpose of ...
INNs granted with specific storage requirements in Bulgarian pharmacies. Part 2: Antineoplastic and immunomodulating agents
Publication Type: Academic Journal
Source(s): Pharmacia, Vol 70, Iss 4, Pp 837-845 (2023)
Abstract: There are drugs that require special storage in Bulgarian pharmacies as well as extra caution during the dispensing process. This is due to serious adverse reactions that may be even fatal. These medicines are included in Appendix № 9 to Art. 17, para....
Molecular docking analysis of ginger (Zingiber officinale) on dopamine compare to bupropion as smoking cessation
Publication Type: Academic Journal
Source(s): Pharmacia, Vol 70, Iss 4, Pp 847-852 (2023)
Abstract: Tobacco use continues to be the leading cause of preventable death worldwide. Smoking is highly addictive because nicotine can stimulate nicotinic acetylcholinergic (nACh) receptors which release dopamine. Smoking cessation can be done with pharmacothe...
Design and evaluation of antifungal vaginal suppository using coconut oil as base for vulvovaginal candidiasis
Publication Type: Academic Journal
Source(s): Future Journal of Pharmaceutical Sciences, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract: Abstract Background The emergence of antimicrobial resistance to antifungals has made vulvovaginal candidiasis a concern. Coconut oil has antimycotic properties that could have a synergistic effect when combined with antifungals. Thus, clotrimazole sup...
Mannose-anchored solid lipid nanoparticles loaded with atorvastatin calcium and vinpocetine as targeted therapy for breast cancer
Publication Type: Academic Journal
Source(s): Future Journal of Pharmaceutical Sciences, Vol 9, Iss 1, Pp 1-18 (2023)
Abstract: Abstract Background This study was aimed to design mannose-conjugated solid lipid nanoparticles (MSLNs) for the targeted delivery of Atorvastatin Calcium (ATS) and Vinpocetine (VIN) to augment its therapeutic efficacy against breast cancer. SLNs were p...
Acinetobacter baumannii biofilm and its potential therapeutic targets
Publication Type: Academic Journal
Source(s): Future Journal of Pharmaceutical Sciences, Vol 9, Iss 1, Pp 1-20 (2023)
Abstract: Abstract Background Acinetobacter baumannii (A. baumannii) is an opportunistic pathogen that poses dangerous health threat. It is a main cause of biofilm-associated infections that are mostly resistant to antibiotic therapy. Because of its capacity to ...
Prevalence of potentially inappropriate medications among elderly patients with diabetes – study based on STOPP/START criteria
Publication Type: Academic Journal
Source(s): Pharmacia, Vol 70, Iss 3, Pp 817-823 (2023)
Abstract: Objective: The prevalence of drug-related problems in elderly patients is a concerning issue that can lead to elevated morbidity, mortality, and health care resource utilisation. This study focuses on the significance of addressing diabetes in the cont...