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Neonatal sepsis definitions from randomised clinical trials.
Publication Type: Report
Source(s): Pediatric research [Pediatr Res] 2023 Apr; Vol. 93 (5), pp. 1141-1148. Date of Electronic Publication: 2021 Nov 06.
Abstract: Introduction: Neonatal sepsis is a leading cause of infant mortality worldwide with non-specific and varied presentation. We aimed to catalogue the current definitions of neonatal sepsis in published randomised controlled trials (RCTs).Method: A system...
Cord blood presepsin as a predictor of early-onset neonatal sepsis in term and preterm newborns.
Publication Type: Academic Journal
Source(s): Italian journal of pediatrics [Ital J Pediatr] 2023 Mar 21; Vol. 49 (1), pp. 35. Date of Electronic Publication: 2023 Mar 21.
Abstract: Background: To date, no studies on presepsin values in cord blood of term infants with risk factors for early-onset sepsis (EOS) are available, whereas only one study reported presepsin values in cord blood of preterm infants at risk. In this study, we...
Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth.
Publication Type: Academic Journal
Source(s): The New England journal of medicine [N Engl J Med] 2023 Mar 30; Vol. 388 (13), pp. 1161-1170. Date of Electronic Publication: 2023 Feb 09.
Abstract: Background: The use of azithromycin reduces maternal infection in women during unplanned cesarean delivery, but its effect on those with planned vaginal delivery is unknown. Data are needed on whether an intrapartum oral dose of azithromycin would redu...
Identification of biomarkers and therapeutic targets related to Sepsis-associated encephalopathy in rats by quantitative proteomics.
Publication Type: Academic Journal
Source(s): BMC genomics [BMC Genomics] 2023 Jan 04; Vol. 24 (1), pp. 4. Date of Electronic Publication: 2023 Jan 04.
Abstract: Background: Sepsis-associated encephalopathy (SAE) is a common and severe complication of sepsis. While several studies have reported the proteomic alteration in plasma, urine, heart, etc. of sepsis, few research focused on the brain tissue. This study...
Presepsin for the Diagnosis of Neonatal Early-Onset Sepsis: A Systematic Review and Meta-analysis.
Publication Type: Academic Journal
Source(s): JAMA pediatrics [JAMA Pediatr] 2022 Aug 01; Vol. 176 (8), pp. 750-758.
Abstract: Importance: Neonatal early-onset sepsis (EOS) is a severe disease, particularly in preterm infants. Timely diagnosis can be challenging owing to unspecific presentation and questionable performance of the common markers of infection. Presepsin was rece...
Prevalence of microbiologically confirmed neonatal sepsis at a maternity center in the City of Buenos Aires.
Publication Type: Academic Journal
Source(s): Archivos argentinos de pediatria [Arch Argent Pediatr] 2023 Jun 01; Vol. 121 (3), pp. e202202779. Date of Electronic Publication: 2023 Feb 09.
Abstract: Introduction. Neonatal sepsis is often suspected in hospitalized newborn infants, but only in 25-30% of cases it is confirmed via a positive culture. Selecting the antibiotics based on local epidemiology favors their rational use and minimizes their si...
High Mobility Group Box 1 (HMGB1): Potential Target in Sepsis-Associated Encephalopathy.
Publication Type: Academic Journal
Source(s): Cells [Cells] 2023 Apr 04; Vol. 12 (7). Date of Electronic Publication: 2023 Apr 04.
Abstract: Sepsis-associated encephalopathy (SAE) remains a challenge for intensivists that is exacerbated by lack of an effective diagnostic tool and an unambiguous definition to properly identify SAE patients. Risk factors for SAE development include age, genet...
Memantine, an NMDA receptor antagonist, protected the brain against the long-term consequences of sepsis in mice.
Publication Type: Academic Journal
Source(s): Life sciences [Life Sci] 2023 Jun 15; Vol. 323, pp. 121695. Date of Electronic Publication: 2023 Apr 14.
Abstract: Aims: Long-term neuroinflammation and brain dysfunction have frequently been reported in sepsis survivors. In this study, the protective effect of memantine (an NMDA receptor antagonist) on the long-term consequences of sepsis on the brain was investig...
Acute kidney injury and early fluid load in a retrospective cohort of neonatal sepsis.
Publication Type: Academic Journal
Source(s): Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2023 Jun; Vol. 38 (6), pp. 1971-1977. Date of Electronic Publication: 2022 Dec 16.
Abstract: Background: Sepsis and acute kidney injury (AKI) are associated with mortality in the newborn intensive care unit (NICU). There is a paucity of studies that describe AKI and fluid overload in neonatal sepsis and their association with mortality.Methods...
Myristica fragrans Extract Inhibits Platelet Desialylation and Activation to Ameliorate Sepsis-Associated Thrombocytopenia in a Murine CLP-Induced Sepsis Model.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 May 16; Vol. 24 (10). Date of Electronic Publication: 2023 May 16.
Abstract: Sepsis, characterized by an uncontrolled host inflammatory response to infections, remains a leading cause of death in critically ill patients worldwide. Sepsis-associated thrombocytopenia (SAT), a common disease in patients with sepsis, is an indicato...