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Advanced Search Results For "SEQUENCE analysis"

1 - 10 of 457,429 results for
 "SEQUENCE analysis"
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Accurate discrimination of leucine and isoleucine residues by combining continuous digestion with multiple MS 3 spectra integration in protein sequence.

Publication Type:Academic Journal

Source(s):Talanta [Talanta] 2022 Nov 01; Vol. 249, pp. 123666. Date of Electronic Publication: 2022 Jun 14.

Abstract:Protein de novo sequencing based on tandem mass spectrometry is a crucial technology that enables the identification of peptides without searching databases and assembling unknown sequence proteins, especially for monoclonal antibodies (mAbs). However,...

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Highly Robust de Novo Full-Length Protein Sequencing.

Publication Type:Academic Journal

Source(s):Analytical chemistry [Anal Chem] 2022 Mar 01; Vol. 94 (8), pp. 3467-3475. Date of Electronic Publication: 2022 Feb 16.

Abstract:Accurate full-length sequencing of a purified unknown protein is still challenging nowadays due to the error-prone mass-spectrometry (MS)-based methods. De novo identified peptide sequence largely contain errors, undermining the accuracy of assembly. B...

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DeepRHD: An efficient hybrid feature extraction technique for protein remote homology detection using deep learning strategies.

Publication Type:Academic Journal

Source(s):Computational biology and chemistry [Comput Biol Chem] 2022 Oct; Vol. 100, pp. 107749. Date of Electronic Publication: 2022 Aug 03.

Abstract:In computational biology, the Protein Remote homology Detection technique (PRHD) has got undeniable significance. It is mostly important for structure and function identification of a protein sequence. The previous years have seen a challenge that lack...

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scMRMA: single cell multiresolution marker-based annotation.

Publication Type:Academic Journal

Source(s):Nucleic acids research [Nucleic Acids Res] 2022 Jan 25; Vol. 50 (2), pp. e7.

Abstract:Single-cell RNA sequencing has become a powerful tool for identifying and characterizing cellular heterogeneity. One essential step to understanding cellular heterogeneity is determining cell identities. The widely used strategy predicts identities by ...

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cpxDeepMSA: A Deep Cascade Algorithm for Constructing Multiple Sequence Alignments of Protein-Protein Interactions.

Publication Type:Academic Journal

Source(s):International journal of molecular sciences [Int J Mol Sci] 2022 Jul 30; Vol. 23 (15). Date of Electronic Publication: 2022 Jul 30.

Abstract:Protein-protein interactions (PPIs) are fundamental to many biological processes. The coevolution-based prediction of interacting residues has made great strides in protein complexes that are known to interact. A multiple sequence alignment (MSA) is th...

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scIMC: a platform for benchmarking comparison and visualization analysis of scRNA-seq data imputation methods.

Publication Type:Academic Journal

Source(s):Nucleic acids research [Nucleic Acids Res] 2022 May 20; Vol. 50 (9), pp. 4877-4899.

Abstract:With the advent of single-cell RNA sequencing (scRNA-seq), one major challenging is the so-called 'dropout' events that distort gene expression and remarkably influence downstream analysis in single-cell transcriptome. To address this issue, much effor...

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Prediction of Disordered Regions in Proteins with Recurrent Neural Networks and Protein Dynamics.

Publication Type:Academic Journal

Source(s):Journal of molecular biology [J Mol Biol] 2022 Jun 30; Vol. 434 (12), pp. 167579. Date of Electronic Publication: 2022 Apr 22.

Abstract:The role of intrinsically disordered protein regions (IDRs) in cellular processes has become increasingly evident over the last years. These IDRs continue to challenge structural biology experiments because they lack a well-defined conformation, and bi...

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CF-Seq, an accessible web application for rapid re-analysis of cystic fibrosis pathogen RNA sequencing studies.

Publication Type:Academic Journal

Source(s):Scientific data [Sci Data] 2022 Jun 16; Vol. 9 (1), pp. 343. Date of Electronic Publication: 2022 Jun 16.

Abstract:Researchers studying cystic fibrosis (CF) pathogens have produced numerous RNA-seq datasets which are available in the gene expression omnibus (GEO). Although these studies are publicly available, substantial computational expertise and manual effort a...

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Researchers Fill Gaps in Human Genome Sequence.

Publication Type:Academic Journal

Source(s):JAMA [JAMA] 2022 May 24; Vol. 327 (20), pp. 1949.

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Comparison of DNA and RNA sequencing of total nucleic acids from human cervix for metagenomics.

Publication Type:Academic Journal

Source(s):Scientific reports [Sci Rep] 2021 Sep 22; Vol. 11 (1), pp. 18852. Date of Electronic Publication: 2021 Sep 22.

Abstract:Although metagenomics and metatranscriptomics are commonly used to identify bacteria and viruses in human samples, few studies directly compare these strategies. We wished to compare DNA and RNA sequencing of bacterial and viral metagenomes and metatra...

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