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Advanced Search Results For "SIGNALS & signaling"

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 "SIGNALS & signaling"
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12- O -tetradecanoylphorbol-13-acetate Reduces Activation of Hepatic Stellate Cells by Inhibiting the Hippo Pathway Transcriptional Coactivator YAP.

Publication Type: Academic Journal

Source(s): Cells [Cells] 2022 Dec 26; Vol. 12 (1). Date of Electronic Publication: 2022 Dec 26.

Authors:

Abstract: Although protein kinase C (PKC) regulates various biological activities, including cell proliferation, differentiation, migration, tissue remodeling, gene expression, and cell death, the antifibrotic effect of PKC in myofibroblasts is not fully underst...

Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling.

Publication Type: Academic Journal

Source(s): Nature chemical biology [Nat Chem Biol] 2023 Jan; Vol. 19 (1), pp. 9-17. Date of Electronic Publication: 2022 Sep 01.

Abstract: The Notch pathway regulates cell fate decisions and is an emerging target for regenerative and cancer therapies. Recombinant Notch ligands are attractive candidates for modulating Notch signaling; however, their intrinsically low receptor-binding affin...

BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation.

Publication Type: Academic Journal

Source(s): Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 Nov; Vol. 9 (31), pp. e2202834. Date of Electronic Publication: 2022 Aug 17.

Abstract: Rho GTPases and Hippo kinases are key regulators of cardiomyoblast differentiation. However, how these signaling axes are coordinated spatiotemporally remains unclear. Here, the central and multifaceted roles of the BCH domain containing protein, BNIP-...

ERK1/2 in immune signalling.

Publication Type: Academic Journal

Source(s): Biochemical Society transactions [Biochem Soc Trans] 2022 Oct 31; Vol. 50 (5), pp. 1341-1352.

Abstract: Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a diverse array of signalling pathways for shaping cell behaviour and fate. Mor...

TAZ/YAP fusion proteins: mechanistic insights and therapeutic opportunities.

Publication Type: Academic Journal

Source(s): Trends in cancer [Trends Cancer] 2022 Dec; Vol. 8 (12), pp. 1033-1045. Date of Electronic Publication: 2022 Sep 09.

Abstract: The Hippo pathway is dysregulated in many different cancers, but point mutations in the pathway are rare. Transcriptional co-activator with PDZ-binding motif (TAZ) and Yes-associated protein (YAP) fusion proteins have emerged in almost all major cancer...

Ad-hoc modifications of cyclic mimetics of SOCS1 protein: Structural and functional insights.

Publication Type: Academic Journal

Source(s): European journal of medicinal chemistry [Eur J Med Chem] 2022 Dec 05; Vol. 243, pp. 114781. Date of Electronic Publication: 2022 Sep 19.

Abstract: Suppressors of cytokine signaling 1 (SOCS1) protein, a negative regulator of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, possesses a small kinase inhibitory region (KIR) involved in the inhibition of JAK kina...

Suppression of YAP safeguards human naïve pluripotency.

Publication Type: Academic Journal

Source(s): Development (Cambridge, England) [Development] 2022 Dec 15; Vol. 149 (24). Date of Electronic Publication: 2022 Dec 21.

Abstract: Propagation of human naïve pluripotent stem cells (nPSCs) relies on the inhibition of MEK/ERK signalling. However, MEK/ERK inhibition also promotes differentiation into trophectoderm (TE). Therefore, robust self-renewal requires suppression of TE fate....

Scaffold proteins as dynamic integrators of biological processes.

Publication Type: Academic Journal

Source(s): The Journal of biological chemistry [J Biol Chem] 2022 Dec; Vol. 298 (12), pp. 102628. Date of Electronic Publication: 2022 Oct 20.

Abstract: Scaffold proteins act as molecular hubs for the docking of multiple proteins to organize efficient functional units for signaling cascades. Over 300 human proteins have been characterized as scaffolds, acting in a variety of signaling pathways. While t...

Yes-Associated Protein and Transcriptional Coactivator with PDZ-Binding Motif in Cardiovascular Diseases.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jan 14; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 14.

Authors:

Abstract: Yes-associated protein (YAP, also known as YAP1) and its paralogue TAZ (with a PDZ-binding motif) are transcriptional coactivators that switch between the cytoplasm and nucleus and regulate the organ size and tissue homeostasis. This review focuses on ...

Extracellular matrix stiffness mediates uterine repair via the Rap1a/ARHGAP35/RhoA/F-actin/YAP axis.

Publication Type: Academic Journal

Source(s): Cell communication and signaling : CCS [Cell Commun Signal] 2023 Jan 23; Vol. 21 (1), pp. 22. Date of Electronic Publication: 2023 Jan 23.

Authors:

Abstract: The integrity of the structure and function of the endometrium is essential for the maintenance of fertility. However, the repair mechanisms of uterine injury remain largely unknown. Here, we showed that the disturbance of mechanical cue homeostasis oc...

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