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Evaluation of In Vitro Tools to Predict the In Vivo Absorption of Biopharmaceuticals Following Subcutaneous Administration.
Publication Type: Academic Journal
Source(s): Journal of pharmaceutical sciences [J Pharm Sci] 2022 Sep; Vol. 111 (9), pp. 2514-2524. Date of Electronic Publication: 2022 Apr 14.
Abstract: Purpose: For injectable biopharmaceuticals, the subcutaneous route of administration is increasingly preferred over intravenous administration. However, one of the challenges in the development of subcutaneously administered biopharmaceuticals is a red...
TAOK1 Promotes Proliferation and Invasion of Non-Small-Cell Lung Cancer Cells by Inhibition of WWC1.
Publication Type: Academic Journal
Source(s): Computational & Mathematical Methods in Medicine. 9/15/2022, Vol. 2022, p1-9. 9p.
Abstract: Background. For patients with advanced non-small-cell lung cancer (NSCLC), targeted therapy significantly improves the therapeutic effect of NSCLC patients. With the development of molecular targeted therapy, more and more NSCLC-related genes have been...
The Role of Jinhuang Powder to Prevent Adverse Effects of Subcutaneous Injection of Enoxaparin Sodium.
Publication Type: Academic Journal
Source(s): Emergency Medicine International. 8/24/2022, p1-6. 6p.
Abstract: Objective. To determine the role of Jinhuang Powder to prevent adverse effects of subcutaneous injection of enoxaparin sodium. Methods. The clinical data of 97 patients with cervical cancer who were treated with subcutaneous injection of enoxaparin thr...
Multiple necrotizing skin lesions due to glatiramer asetate injection .
Publication Type: Academic Journal
Source(s): Neurology Asia. 2022, Vol. 27 Issue 4, p1053-1055. 3p.
Abstract: Nicolau’s syndrome due to glatiramer acetate (GA) injection has been rarely reported. We report a 35-year-old woman with multiple sclerosis who presented with two necrotizing skin lesions due to consecutive subcutaneous GA injection. The patient was di...
Subkutánní forma natalizumabu v terapii vysoce aktivní relabující-remitující roztroušené sklerózy.
Publication Type: Academic Journal
Source(s): Česká a Slovenská Neurologie a Neurochirurgie. 2022, Vol. 85 Issue 3, p206-212. 7p.
Abstract: Monoklonální protilátky (monoclonal antibodies; MAbs) patří mezi nejrychleji se rozvíjející typy moderních biologických léčiv schválených pro řadu různých indikací. S příchodem humanizovaných a humánních MAbs dochází k významnému zlepšení jejich bezpeč...
Predictive Factors for Rheumatoid Arthritis Flare After Switching From Intravenous to Subcutaneous Formulation of Tocilizumab in Real-World Practice.
Publication Type: Academic Journal
Source(s): Journal of Korean medical science [J Korean Med Sci] 2022 May 02; Vol. 37 (17), pp. e138. Date of Electronic Publication: 2022 May 02.
Abstract: Background: To evaluate the incidence and related factors of rheumatoid arthritis (RA) flares after switching from intravenous tocilizumab (TCZ-IV) to subcutaneous tocilizumab (TCZ-SC) injection in stable RA patients.Methods: We retrospectively evaluat...
An Open-Label, Multinational, Multicenter, Phase IIIb Study with Subcutaneous Administration of Trastuzumab in Patients with HER2-Positive Early Breast Cancer to Evaluate Patient Satisfaction.
Publication Type: Academic Journal
Source(s): European Journal of Breast Health. Jan2022, Vol. 18 Issue 1, p63-73. 11p.
Abstract: Objective: This study was designed to investigate treatment satisfaction in patients and Health Care Professionals (HCP) and to evaluate the safety and tolerability of subcutaneous (SC) trastuzumab in patients with human epidermal growth factor recepto...
Real-world results with IgPro20 for hypo- or agammaglobulinemia in Japan.
Publication Type: Academic Journal
Source(s): Pediatrics international : official journal of the Japan Pediatric Society [Pediatr Int] 2022 Jan; Vol. 64 (1), pp. e15362.
Abstract: Background: Subcutaneous immunoglobulin is one of the standard treatments for hypogammaglobulinemia in primary immunodeficiencies (PID) worldwide. In Japan, IgPro20 (Hizentra ® ; l-proline-stabilized 20% human subcutaneous immunoglobulin) is approved f...
Tumescent Injections in Subcutaneous Pig Tissue Disperse Fluids Volumetrically and Maintain Elevated Local Concentrations of Additives for Several Hours, Suggesting a Treatment for Drug Resistant Wounds.
Publication Type: Academic Journal
Source(s): Pharmaceutical research [Pharm Res] 2020 Feb 10; Vol. 37 (3), pp. 51. Date of Electronic Publication: 2020 Feb 10.
Abstract: Purpose: Bolus injection of fluid into subcutaneous tissue results in accumulation of fluid at the injection site. The fluid does not form a pool. Rather, the injection pressure forces the interstitial matrix to expand to accommodate the excess fluid i...
A narrative review on subcutaneous injection components used for alopecia.
Publication Type: Academic Journal
Source(s): Journal of Cosmetic Dermatology. Mar2023, Vol. 22 Issue 3, p776-783. 8p.
Abstract: Background: Studies reporting the development and effectiveness of topical agents for alopecia are available. However, it was difficult to demonstrate a direct advantage of subcutaneous injection rather than topical application. Since existing articles...