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缺血后处理通过ROS-TXNIP-NLRP3-GSDMD 途径抑制大鼠肺缺血/再灌注诱导的细胞焦亡.
Publication Type: Academic Journal
Source(s): Chinese Journal of Pathophysiology. 2023, Vol. 39 Issue 6, p1005-1013. 9p.
Abstract: 探讨核苷酸结合寡聚化结构域样受体蛋白3（nucleotide-binding oligomerization domain-like receptor protein 3, NLRP3）炎症小体介导的细胞焦亡在大鼠肺缺血/再灌注损伤（lung ischemia/reperfusion injury, LIRI）中的作用及缺血后处理（ischemic post-conditioning, I-post-C）的干预效果。方法: 将20只6~8周龄SPF级雄性 SD大鼠随机分为4组: 对照（control...
The Oligostilbene Gnetin H Is a Novel Glycolysis Inhibitor That Regulates Thioredoxin Interacting Protein Expression and Synergizes with OXPHOS Inhibitor in Cancer Cells.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. May2023, Vol. 24 Issue 9, p7741. 22p.
Abstract: Since aerobic glycolysis was first observed in tumors almost a century ago by Otto Warburg, the field of cancer cell metabolism has sparked the interest of scientists around the world as it might offer new avenues of treatment for malignant cells. Our ...
Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells.
Publication Type: Academic Journal
Source(s): Toxins. Apr2023, Vol. 15 Issue 4, p300. 13p.
Abstract: Deoxynivalenol (DON) is known as a vomitoxin, which frequently contaminates feedstuffs, such as corn, wheat, and barley. Intake of DON-contaminated feed has been known to cause undesirable effects, including diarrhea, emesis, reduced feed intake, nutri...
Myocardial Glutathione Synthase and TRXIP Expression Are Significantly Elevated in Hypertension and Diabetes: Influence of Stress on Antioxidant Pathways.
Publication Type: Academic Journal
Source(s): Pathophysiology. Jun2023, Vol. 30 Issue 2, p248-259. 12p.
Abstract: Antioxidant protection is one of the key reactions of cardiomyocytes (CMCs) in response to myocardial damage of various origins. The thioredoxin interacting protein (TXNIP) is an inhibitor of thioredoxin (TXN). Over the recent few years, TXNIP has rece...
The Role of Txnip in Mediating Low-Magnesium-Driven Endothelial Dysfunction.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. May2023, Vol. 24 Issue 9, p8351. 13p.
Abstract: Magnesium deficiency is associated with a greater risk of developing cardiovascular diseases since this cation is fundamental in regulating vascular function. This clinical evidence is sustained by in vitro studies showing that culturing endothelial ce...
Regulatory Mechanism on Anti-Glycolytic and Anti-Metastatic Activities Induced by Strobilanthes crispus in Breast Cancer, In Vitro.
Publication Type: Academic Journal
Source(s): Pharmaceuticals (14248247). Feb2023, Vol. 16 Issue 2, p153. 18p.
Abstract: An active fraction of S. crispus, F3, and its bioactive compounds (lutein, β-sitosterol, and stigmasterol) were reported to have anti-glycolytic activities in MDA-MB-231 cells. Since glycolysis can also regulate metastatic activities in cancer cells, t...
Long-Term IGF1 Stimulation Leads to Cellular Senescence via Functional Interaction with the Thioredoxin-Interacting Protein, TXNIP.
Publication Type: Academic Journal
Source(s): Cells (2073-4409). Oct2022, Vol. 11 Issue 20, p3260-N.PAG. 23p.
Abstract: The growth hormone (GH)–insulin-like growth factor-1 (IGF1) signaling pathway plays a major role in orchestrating cellular interactions, metabolism, growth and aging. Studies from worms to mice showed that downregulated activity of the GH/IGF1 pathway ...
Tremella fuciformis polysaccharides alleviates UV-provoked skin cell damage via regulation of thioredoxin interacting protein and thioredoxin reductase 2.
Publication Type: Academic Journal
Source(s): Photochemical & Photobiological Sciences. Oct2023, Vol. 22 Issue 10, p2285-2296. 12p.
Abstract: Introduction: Skin is exposed to a wide range of environmental risk factors including ultraviolet (UV) and all kinds of pollutants. Excessive UV exposure contributes to many disorders, such as photoaging, skin inflammation, and carcinogenesis. Previous...
Editorial for Special Issue on "Regulation and Effect of Taurine on Metabolism".
Publication Type: Academic Journal
Source(s): Metabolites (2218-1989). Sep2022, Vol. 12 Issue 9, p795-N.PAG. 5p.
Abstract: The authors reviewed what is known about taurine's role in the physiological functions of skeletal muscles, including the impact of taurine depletion in skeletal muscles in I Taut i -KO mice and in mice treated with the TAUT antagonist guanodinoethane ...
Signaling Pathway of Taurine-Induced Upregulation of TXNIP.
Publication Type: Academic Journal
Source(s): Metabolites (2218-1989). Jul2022, Vol. 12 Issue 7, pN.PAG-N.PAG. 15p.
Abstract: Taurine, a sulfur-containing β-amino acid, is present at high concentrations in mammalian tissues and plays an important role in several essential biological processes. However, the genetic mechanisms involved in these physiological processes associate...