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Mettl1-mediated internal m7G methylation of Sptbn2 mRNA elicits neurogenesis and anti-alzheimer’s disease
Publication Type: Academic Journal
Source(s): Cell & Bioscience, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract: Abstract Background N7-methylguanosine (m7G) is one of the most conserved modifications in nucleosides impacting mRNA export, splicing, and translation. However, the precise function and molecular mechanism of internal mRNA m7G methylation in adult hip...
Non‐A to E hepatitis in children: Detecting a novel viral epidemic during the COVID‐19 pandemic
Publication Type: Academic Journal
Source(s): Microbial Biotechnology, Vol 16, Iss 10, Pp 1879-1887 (2023)
Abstract: Abstract During the COVID‐19 pandemic, two further novel viral epidemics were described in 2022, monkeypox virus infections in men having sex with men and non‐A to E hepatitis in children. The latter occurred in the first half of 2022 with about 1000 c...
Design of a chimeric glycosyltransferase OleD for the site‐specific O‐monoglycosylation of 3‐hydroxypyridine in nosiheptide
Publication Type: Academic Journal
Source(s): Microbial Biotechnology, Vol 16, Iss 10, Pp 1971-1984 (2023)
Abstract: Abstract To identify the potential role of the 3‐hydroxyl group of the pyridine ring in nosiheptide (NOS) for its antibacterial activity against Gram‐positive pathogens, enzymatic glycosylation was utilized to regio‐selectively create a monoglycosyl NO...
Akkermansia muciniphila alleviates high‐fat‐diet‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids
Publication Type: Academic Journal
Source(s): Microbial Biotechnology, Vol 16, Iss 10, Pp 1924-1939 (2023)
Abstract: Abstract It has been reported that Akkermansia muciniphila improves host metabolism and reduces inflammation; however, its potential effects on bile acid metabolism and metabolic patterns in metabolic‐associated fatty liver disease (MAFLD) are unknown....
Science, method and critical thinking
Publication Type: Academic Journal
Source(s): Microbial Biotechnology, Vol 16, Iss 10, Pp 1888-1894 (2023)
Abstract: Abstract Science is founded on a method based on critical thinking. A prerequisite for this is not only a sufficient command of language but also the comprehension of the basic concepts underlying our understanding of reality. This constraint implies a...
Role of 6‐phosphogluconate dehydrogenase enzyme 1 in growth and virulence of Toxoplasma gondii and development of attenuated live vaccine
Publication Type: Academic Journal
Source(s): Microbial Biotechnology, Vol 16, Iss 10, Pp 1957-1970 (2023)
Abstract: Abstract Toxoplasma gondii is a ubiquitous pathogen that infects all warm‐blooded animals, including humans, causing substantial socioeconomic and healthcare burdens. However, there is no ideal vaccine for toxoplasmosis. As metabolism is important in t...
Dysbiosis of intestinal homeostasis contribute to Whitmania pigra edema disease
Publication Type: Academic Journal
Source(s): Microbial Biotechnology, Vol 16, Iss 10, Pp 1940-1956 (2023)
Abstract: Abstract Whitmania pigra is widely used in traditional Chinese medicine. However, W. pigra is being threatened by an edema disease with unknown causes (WPE). In this study, a comprehensive exploration of virome, microbiome, and metabolome aberrations i...
Synthetic microbial consortia for the treatment of Clostridioides difficile infection in mice model
Publication Type: Academic Journal
Source(s): Microbial Biotechnology, Vol 16, Iss 10, Pp 1985-2006 (2023)
Abstract: Abstract Clostridioides difficile infection (CDI) as of recent has become a great concern to the impact on human health due to its high hazardous risk and rate of recurrence. Live bacterial therapeutics is a promising method to treat or prevent CDI. He...
What are the missing pieces needed to stop antibiotic resistance?
Publication Type: Academic Journal
Source(s): Microbial Biotechnology, Vol 16, Iss 10, Pp 1900-1923 (2023)
Abstract: Abstract As recognized by several international agencies, antibiotic resistance is nowadays one of the most relevant problems for human health. While this problem was alleviated with the introduction of new antibiotics into the market in the golden age...
A microbial evolutionary approach for a sustainable future
Publication Type: Academic Journal
Source(s): Microbial Biotechnology, Vol 16, Iss 10, Pp 1895-1899 (2023)
Abstract: Abstract With the continued population increase, more sustainable use of water, land, air and chemicals is imperative. Microorganisms will need to be called upon to aid in many sustainability efforts. Prokaryotes are the fastest‐evolving cellular life,...