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A mechanistic overview of sulforaphane and its derivatives application in diabetes and its complications.
Publication Type: Academic Journal
Source(s): Inflammopharmacology [Inflammopharmacology] 2023 Dec; Vol. 31 (6), pp. 2885-2899. Date of Electronic Publication: 2023 Nov 13.
Abstract: Sulforaphane (SFN) is a type of phytochemical found in many cruciferous vegetables that has been shown to positively benefit the control of Type 2 Diabetes Mellitus (T2DM). The search was done from 2000 until December 2022 using PubMed, Scopus, Web of ...
Vitamin K1 Intake and Incident Diabetes in the Danish Diet, Cancer, and Health Study.
Publication Type: Academic Journal
Source(s): The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2023 Oct 18; Vol. 108 (11), pp. e1253-e1263.
Abstract: Context: Observational studies have reported lower risks of type 2 diabetes with higher vitamin K1 intake, but these studies overlook effect modification due to known diabetes risk factors.Objective: To identify subgroups that might benefit from vitami...
Sodium-glucose cotransporter-2 inhibition for heart failure with preserved ejection fraction and chronic kidney disease with or without type 2 diabetes mellitus: a narrative review.
Publication Type: Academic Journal
Source(s): Cardiovascular diabetology [Cardiovasc Diabetol] 2023 Nov 16; Vol. 22 (1), pp. 316. Date of Electronic Publication: 2023 Nov 16.
Abstract: Background: Heart failure (HF), chronic kidney disease (CKD), and type 2 diabetes mellitus (T2DM) are common and interrelated conditions, each with a significant burden of disease. HF and kidney disease progress through pathophysiologic pathways that c...
L-type calcium ion channel-mediated activation of autophagy in vascular smooth muscle cells via thonningianin A (TA) alleviates vascular calcification in type 2 diabetes mellitus.
Publication Type: Academic Journal
Source(s): European journal of pharmacology [Eur J Pharmacol] 2023 Nov 15; Vol. 959, pp. 176084. Date of Electronic Publication: 2023 Oct 06.
Abstract: Vascular calcification (VC) is associated with increased morbidity and mortality, especially among people with type 2 diabetes mellitus (T2DM). The pathogenesis of vascular calcification is incompletely understood, and until now, there have been no eff...
Lymphocytes regulate expression of the SARS-CoV-2 cell entry factor ACE2 in the pancreas of T2DM patients.
Publication Type: Academic Journal
Source(s): Diabetic medicine : a journal of the British Diabetic Association [Diabet Med] 2023 Oct; Vol. 40 (10), pp. e15106. Date of Electronic Publication: 2023 Apr 11.
Abstract: Aims: COVID-19 patients with type 2 diabetes mellitus (T2DM) show both poorer clinical outcomes and have an increased risk of death. SARS-CoV-2 virus infection requires simultaneous expression of the SARS-CoV-2 cell entry factors angiotensin-converting...
Effects of once-weekly glucagon-like peptide-1 receptor agonists on type 2 diabetes mellitus complicated with coronary artery disease: Potential role of the renin-angiotensin system.
Publication Type: Academic Journal
Source(s): Diabetes, obesity & metabolism [Diabetes Obes Metab] 2023 Nov; Vol. 25 (11), pp. 3223-3234. Date of Electronic Publication: 2023 Aug 02.
Abstract: Aim: To investigate the potential mechanism of once-weekly glucagon-like peptide-1 receptor agonists (GLP-1 RA) in the treatment of type 2 diabetes mellitus (T2DM) complicated with coronary artery disease (CAD).Methods: We searched both Chinese and Eng...
Sodium glucose co-transporter 2 inhibition increases epidermal growth factor expression and improves outcomes in patients with type 2 diabetes.
Publication Type: Academic Journal
Source(s): Kidney international [Kidney Int] 2023 Oct; Vol. 104 (4), pp. 828-839. Date of Electronic Publication: 2023 Aug 04.
Abstract: Underlying molecular mechanisms of the kidney protective effects of sodium glucose co-transporter 2 (SGLT2) inhibitors are not fully elucidated. Therefore, we studied the association between urinary epidermal growth factor (uEGF), a mitogenic factor in...
SGLT2 and DPP4 inhibitors improve Alzheimer's disease-like pathology and cognitive function through distinct mechanisms in a T2D-AD mouse model.
Publication Type: Academic Journal
Source(s): Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Dec; Vol. 168, pp. 115755. Date of Electronic Publication: 2023 Oct 21.
Abstract: Alzheimer's disease (AD) and type 2 diabetes mellitus (T2D) share common features, including insulin resistance. Brain insulin resistance has been implicated as a key factor in the pathogenesis of AD. Recent studies have demonstrated that anti-diabetic...
Preconception SGLT2 or DPP4 inhibitor use and adverse pregnancy outcomes.
Publication Type: Academic Journal
Source(s): Diabetes research and clinical practice [Diabetes Res Clin Pract] 2023 Nov; Vol. 205, pp. 110946. Date of Electronic Publication: 2023 Oct 07.
Abstract: Aims: To compare preconception use of sodium-glucose cotransporter-2 (SGLT2i) and dipeptidyl peptidase-4 (DPP4i) inhibitors to sulfonylurea agents, and associated peri-conceptional A1c concentration, and risk of pregnancy loss and congenital anomalies....
Oxidative Stress-regulating Enzymes and Endometrial Cancer Survival in Relation to Metformin Intake in Diabetic Patients.
Publication Type: Academic Journal
Source(s): Anticancer research [Anticancer Res] 2023 Dec; Vol. 43 (12), pp. 5545-5554.
Abstract: Background/aim: Metformin inhibits tumorigenesis in endometrial carcinoma and interferes with the expression of oxidative stress-regulating proteins, such as nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Ke...