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Advanced Search Results For "Therapeutics. Pharmacology"

1 - 10 of 432,197 results for
 "Therapeutics. Pharmacology"
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A quantitative systems pharmacology model of plasma potassium regulation by the kidney and aldosterone.

Publication Type:Academic Journal

Source(s):Journal of pharmacokinetics and pharmacodynamics [J Pharmacokinet Pharmacodyn] 2022 Aug; Vol. 49 (4), pp. 471-486. Date of Electronic Publication: 2022 Jul 01.

Abstract:Plasma potassium regulation within a narrow range is vital for life. The risk for hyperkalemia increases when kidney function is impaired and with therapeutic interventions such as mineralocorticoid receptor antagonists (MRAs). The kidney maintains pot...

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Network Pharmacology and Molecular Docking-Based Mechanism Study to Reveal Antihypertensive Effect of Gedan Jiangya Decoction.

Publication Type:Academic Journal

Source(s):BioMed research international [Biomed Res Int] 2022 Aug 22; Vol. 2022, pp. 3353464. Date of Electronic Publication: 2022 Aug 22 (Print Publication: 2022).

Abstract:Primary hypertension is understood as a disease with diverse etiology, a complicated pathological mechanism, and progressive changes. Gedan Jiangya Decoction (GJD), with the patent publication number CN114246896A, was designed to treat primary hyperten...

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Potential active compounds and molecular mechanism of Xuefu Zhuyu decoction for atherosclerosis, based on network pharmacology and molecular docking.

Publication Type:Academic Journal

Source(s):Medicine [Medicine (Baltimore)] 2022 Aug 12; Vol. 101 (32), pp. e29654.

Abstract:To explore the potential active compounds and molecular mechanism of Xuefu Zhuyu decoction (XFZYD) in the treatment of atherosclerosis (AS) based on network pharmacology and molecular docking. The effective components and action targets of XFZYD were s...

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The clinical pharmacology and potential therapeutic applications of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT).

Publication Type:Academic Journal

Source(s):Journal of neurochemistry [J Neurochem] 2022 Jul; Vol. 162 (1), pp. 128-146. Date of Electronic Publication: 2022 Mar 08.

Abstract:5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring tryptamine that primarily acts as an agonist at the 5-HT1A and 5-HT2A receptors, whereby affinity for the 5-HT1A subtype is highest. Subjective effects following 5-MeO-DMT administra...

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To study the mechanism of Scutellariae Radix and Astragaloside in the treatment of lung cancer based on network pharmacology.

Publication Type:Academic Journal

Source(s):Medicine [Medicine (Baltimore)] 2022 Jul 01; Vol. 101 (26), pp. e29729. Date of Electronic Publication: 2022 Jul 01.

Abstract:The aim of the study wasto explore the target and potential mechanism of Scutellariae Radix and Astragaloside in the treatment of lung cancer infection by network pharmacology. The target information of baicalein and flavonin was mined from CTD databas...

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Molecular mechanism of Sishen pills in the treatment of diarrheal diabetic enteropathy based on network pharmacology.

Publication Type:Academic Journal

Source(s):Medicine [Medicine (Baltimore)] 2022 Sep 02; Vol. 101 (35), pp. e30096.

Abstract:This study aimed to explore the effectiveness and safety of Sishen pills for the treatment of diarrheal diabetic enteropathy (DDE). The Traditional Chinese Medicine (TCM) Systems Pharmacology and BATMAN-TCM databases were used to determine the chemical...

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Trimetazidine, a metabolic modulator, attenuates silica-induced pulmonary fibrosis and decreases lactate levels and LDH activity in rats.

Publication Type:Academic Journal

Source(s):Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2022 Jul; Vol. 36 (7), pp. e23071. Date of Electronic Publication: 2022 Apr 11.

Abstract:Pulmonary fibrosis has been recently linked to metabolic dysregulation. Silica-induced pulmonary fibrosis in rats was employed by the current study to explore the effects of trimetazidine (a metabolic modulator-antianginal drug; TMZ) on silica-induced ...

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Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia.

Publication Type:Academic Journal

Source(s):Journal of ethnopharmacology [J Ethnopharmacol] 2022 Nov 15; Vol. 298, pp. 115679. Date of Electronic Publication: 2022 Sep 01.

Abstract:Ethnopharmacological Relevance: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect of dispelling dampness and dispersing cold. In clinical practice, SWR is generally used for the treatment of hyperuricemia (HUA). H...

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Network pharmacology-based prediction and verification of the active ingredients and potential targets of Huagan Decoction for reflux esophagitis.

Publication Type:Academic Journal

Source(s):Journal of ethnopharmacology [J Ethnopharmacol] 2022 Nov 15; Vol. 298, pp. 115629. Date of Electronic Publication: 2022 Aug 18.

Abstract:Ethnopharmacological Relevance: Huagan Decoction (HGD), a famous traditional Chinese medicine (TCM) formula, has been widely used in the treatment of reflux esophagitis (RE). However, its effective compounds, potential targets and molecular mechanism r...

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Network pharmacology and molecular docking study on the effect of Kaempferol in treatment of metabolic associated fatty liver disease.

Publication Type:Academic Journal

Source(s):Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan [J Tradit Chin Med] 2022 Oct; Vol. 42 (5), pp. 788-794.

Abstract:Objective: To study therapeutic effect of kaempferol on metabolic associated fatty liver disease (MAFLD) by network pharmacology and molecular docking combined with cell experiments.Methods: First, use the SwissTargetPrediction database to predict the ...

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